PL438753A1 - Sposób otrzymywania nanożeli uwalniających kowalencyjnie związaną trehalozę - Google Patents

Sposób otrzymywania nanożeli uwalniających kowalencyjnie związaną trehalozę

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Publication number
PL438753A1
PL438753A1 PL438753A PL43875321A PL438753A1 PL 438753 A1 PL438753 A1 PL 438753A1 PL 438753 A PL438753 A PL 438753A PL 43875321 A PL43875321 A PL 43875321A PL 438753 A1 PL438753 A1 PL 438753A1
Authority
PL
Poland
Prior art keywords
trehalose
releasing
monomers
covalently bound
nanogels
Prior art date
Application number
PL438753A
Other languages
English (en)
Inventor
Ilona Wandzik
Małgorzata Milewska
Ali Maruf
Original Assignee
Politechnika Śląska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Śląska filed Critical Politechnika Śląska
Priority to PL438753A priority Critical patent/PL438753A1/pl
Publication of PL438753A1 publication Critical patent/PL438753A1/pl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania nanożeli uwalniających kowalencyjnie związaną trehalozę, który polega na tym, że prowadzi się kopolimeryzację wolnorodnikową z udziałem (met)akrylanu-6-O-trehalozy o wzorze ogólnym 1, gdzie R = H lub CH<sub>3</sub> w ilości od 10%  do 90% wagowych w stosunku do wszystkich monomerów, z co najmniej jednym monomerem z grupy monomerów akrylamidowych w ilości co najmniej 10% w stosunku do wszystkich monomerów, w obecności czynnika sieciującego w ilości od 0,5% do 20,0% wagowych wszystkich monomerów, korzystnie w zakresie 5 - 10%  wagowych. Przedmiotem zgłoszenia jest również zastosowanie nanożeli otrzymanych sposobem określonym powyżej do przedłużonego uwalniania trehalozy w mediach wodnych o pH > 7,0.
PL438753A 2021-08-16 2021-08-16 Sposób otrzymywania nanożeli uwalniających kowalencyjnie związaną trehalozę PL438753A1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL438753A PL438753A1 (pl) 2021-08-16 2021-08-16 Sposób otrzymywania nanożeli uwalniających kowalencyjnie związaną trehalozę

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL438753A PL438753A1 (pl) 2021-08-16 2021-08-16 Sposób otrzymywania nanożeli uwalniających kowalencyjnie związaną trehalozę

Publications (1)

Publication Number Publication Date
PL438753A1 true PL438753A1 (pl) 2023-02-20

Family

ID=85225408

Family Applications (1)

Application Number Title Priority Date Filing Date
PL438753A PL438753A1 (pl) 2021-08-16 2021-08-16 Sposób otrzymywania nanożeli uwalniających kowalencyjnie związaną trehalozę

Country Status (1)

Country Link
PL (1) PL438753A1 (pl)

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