PL430872A1 - Sposób wytwarzania (+)-izomeru-(3R)-3-n-butyloftalidu - Google Patents
Sposób wytwarzania (+)-izomeru-(3R)-3-n-butyloftaliduInfo
- Publication number
- PL430872A1 PL430872A1 PL430872A PL43087219A PL430872A1 PL 430872 A1 PL430872 A1 PL 430872A1 PL 430872 A PL430872 A PL 430872A PL 43087219 A PL43087219 A PL 43087219A PL 430872 A1 PL430872 A1 PL 430872A1
- Authority
- PL
- Poland
- Prior art keywords
- butylphthalide
- isomer
- formula
- added
- preparation
- Prior art date
Links
- HJXMNVQARNZTEE-LLVKDONJSA-N (3r)-3-butyl-3h-2-benzofuran-1-one Chemical compound C1=CC=C2[C@@H](CCCC)OC(=O)C2=C1 HJXMNVQARNZTEE-LLVKDONJSA-N 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- XSBJHHGHIOQABT-UHFFFAOYSA-N CCCCC(O)C1=CC=CC=C1CO Chemical compound CCCCC(O)C1=CC=CC=C1CO XSBJHHGHIOQABT-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000001888 Peptone Substances 0.000 abstract 1
- 108010080698 Peptones Proteins 0.000 abstract 1
- 241000187563 Rhodococcus ruber Species 0.000 abstract 1
- 229940041514 candida albicans extract Drugs 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000002054 inoculum Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 235000019319 peptone Nutrition 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000012138 yeast extract Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Sposób wytwarzania (+)-izomeru-(3R)-3-n-butyloftalidu, charakteryzujący się tym, że do podłoża składającego się z 1% peptonu, 0,2% kazeiny, 0,2% ekstraktu drożdżowego, 6% chlorku sodu i 2% glukozy dodaje się inoculum hodowli Rhodococcus ruber PCM2166, kolejno po upływie co najmniej 48 godzin, dodaje się racemiczny 1-hydroksymetylo-2-(1-hydroksypentylo)benzen o wzorze 1, o stężeniu nie większym niż 0,6 g/dm3, następnie po całkowitym przereagowaniu substratu, produkt ekstrahuje się, po uprzednim zakwaszeniu kwasem solnym do pH nie wyższego niż 4, otrzymując (+)-izomer-(3R)-3-n-butyloftalid o wzorze 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL430872A PL238970B1 (pl) | 2019-08-14 | 2019-08-14 | Sposób wytwarzania (+)-izomeru-(3R)-3-n-butyloftalidu |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL430872A PL238970B1 (pl) | 2019-08-14 | 2019-08-14 | Sposób wytwarzania (+)-izomeru-(3R)-3-n-butyloftalidu |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL430872A1 true PL430872A1 (pl) | 2021-02-22 |
| PL238970B1 PL238970B1 (pl) | 2021-10-25 |
Family
ID=74647751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL430872A PL238970B1 (pl) | 2019-08-14 | 2019-08-14 | Sposób wytwarzania (+)-izomeru-(3R)-3-n-butyloftalidu |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL238970B1 (pl) |
-
2019
- 2019-08-14 PL PL430872A patent/PL238970B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL238970B1 (pl) | 2021-10-25 |
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