PL430348A1 - Związek chemiczny - marker diagnostyczny nowotworu trzustki oraz sposób diagnozowania in vitro nowotworu trzustki - Google Patents
Związek chemiczny - marker diagnostyczny nowotworu trzustki oraz sposób diagnozowania in vitro nowotworu trzustkiInfo
- Publication number
- PL430348A1 PL430348A1 PL430348A PL43034819A PL430348A1 PL 430348 A1 PL430348 A1 PL 430348A1 PL 430348 A PL430348 A PL 430348A PL 43034819 A PL43034819 A PL 43034819A PL 430348 A1 PL430348 A1 PL 430348A1
- Authority
- PL
- Poland
- Prior art keywords
- chemical compound
- diagnostic marker
- anb
- cancer
- acid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003550 marker Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 title abstract 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 title abstract 2
- 201000002528 pancreatic cancer Diseases 0.000 title abstract 2
- 208000008443 pancreatic carcinoma Diseases 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 2
- TYMLOMAKGOJONV-UHFFFAOYSA-N 4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1 TYMLOMAKGOJONV-UHFFFAOYSA-N 0.000 abstract 1
- KZZWQCKYLNIOBT-UHFFFAOYSA-N 5-amino-2-nitrobenzoic acid Chemical compound NC1=CC=C([N+]([O-])=O)C(C(O)=O)=C1 KZZWQCKYLNIOBT-UHFFFAOYSA-N 0.000 abstract 1
- 238000002835 absorbance Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/067—Pancreatitis or colitis
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Przedmiotem wynalazku jest związek chemiczny - marker diagnostyczny o wzorze ogólnym, gdzie: ABZ oznacza kwas 2-aminobenzoesowy, X to oznacza ANB-NH2 lub pNA, przy czym ANB-NH2 oznacza amid kwasu 5-amino-2-benzoesowego, ANB - kwas 5-amino-2-nitrobenzoesowy, a pNA oznacza para-nitroanilinę. Przedmiotem wynalazku jest także sposób otrzymywania tego związku chemicznego - markera diagnostycznego, prowadzony na nośniku, którym jest żywica oraz w buforze. Sposób diagnozowania nowotworu trzustki polega na tym, że związek chemiczny - marker diagnostyczny w przedziale stężeń 0.1 - 10 mg/ml inkubuje się w buforze pomiarowym o pH obojętnym lub zasadowym z niewielką ilością ludzkiego moczu, w zakresie proporcji 1:2 do 1:10 do buforu pomiarowego, i mierzy się intensywność absorbancji w zakresie 300-500 nm.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL430348A PL241174B1 (pl) | 2019-06-24 | 2019-06-24 | Związek chemiczny-marker diagnostyczny nowotworu trzustki oraz sposób diagnozowania in vitro nowotworu trzustki |
| US17/622,070 US12668831B2 (en) | 2019-06-24 | 2020-06-23 | Diagnostic marker for pancreatic cancer |
| MX2021016095A MX2021016095A (es) | 2019-06-24 | 2020-06-23 | Nuevo marcador de diagnostico para cancer pancreatico. |
| BR112021026192A BR112021026192A2 (pt) | 2019-06-24 | 2020-06-23 | Marcador de diagnóstico para câncer pancreático |
| CN202080045600.3A CN114096555A (zh) | 2019-06-24 | 2020-06-23 | 新型胰腺癌诊断标志物 |
| PCT/EP2020/067542 WO2020260309A1 (en) | 2019-06-24 | 2020-06-23 | Novel diagnostic marker for pancreatic cancer |
| KR1020227002283A KR102798031B1 (ko) | 2019-06-24 | 2020-06-23 | 새로운 췌장암 진단 마커 |
| AU2020306623A AU2020306623B2 (en) | 2019-06-24 | 2020-06-23 | Novel diagnostic marker for pancreatic cancer |
| EP20733488.9A EP3987050A1 (en) | 2019-06-24 | 2020-06-23 | Novel diagnostic marker for pancreatic cancer |
| JP2021577260A JP7601804B2 (ja) | 2019-06-24 | 2020-06-23 | 膵臓がんの新規診断マーカー |
| CA3144839A CA3144839A1 (en) | 2019-06-24 | 2020-06-23 | Diagnostic marker for pancreatic cancer |
| IL289348A IL289348A (en) | 2019-06-24 | 2021-12-23 | Novel diagnostic marker for pancreatic cancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL430348A PL241174B1 (pl) | 2019-06-24 | 2019-06-24 | Związek chemiczny-marker diagnostyczny nowotworu trzustki oraz sposób diagnozowania in vitro nowotworu trzustki |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL430348A1 true PL430348A1 (pl) | 2020-12-28 |
| PL241174B1 PL241174B1 (pl) | 2022-08-16 |
Family
ID=83560142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL430348A PL241174B1 (pl) | 2019-06-24 | 2019-06-24 | Związek chemiczny-marker diagnostyczny nowotworu trzustki oraz sposób diagnozowania in vitro nowotworu trzustki |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL241174B1 (pl) |
-
2019
- 2019-06-24 PL PL430348A patent/PL241174B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL241174B1 (pl) | 2022-08-16 |
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