PL428993A1 - Hydrożelowy materiał hybrydowy, sposób jego otrzymywania i zastosowanie - Google Patents
Hydrożelowy materiał hybrydowy, sposób jego otrzymywania i zastosowanieInfo
- Publication number
- PL428993A1 PL428993A1 PL428993A PL42899319A PL428993A1 PL 428993 A1 PL428993 A1 PL 428993A1 PL 428993 A PL428993 A PL 428993A PL 42899319 A PL42899319 A PL 42899319A PL 428993 A1 PL428993 A1 PL 428993A1
- Authority
- PL
- Poland
- Prior art keywords
- sol
- silica particles
- functionalized silica
- hybrid material
- preparation
- Prior art date
Links
- 239000000017 hydrogel Substances 0.000 title abstract 3
- 239000000463 material Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
- 229920001661 Chitosan Polymers 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 2
- 108010035532 Collagen Proteins 0.000 abstract 2
- 229920001436 collagen Polymers 0.000 abstract 2
- 229920002674 hyaluronan Polymers 0.000 abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 abstract 2
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000003980 solgel method Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
- C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
- C09C1/28—Compounds of silicon
- C09C1/30—Silicic acid
- C09C1/3063—Treatment with low-molecular organic compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
- C09C3/00—Treatment in general of inorganic materials, other than fibrous fillers, to enhance their pigmenting or filling properties
- C09C3/08—Treatment with low-molecular-weight non-polymer organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania hydrożelowego materiału hybrydowego, charakteryzujący się tym, że obejmuje następujące etapy: a) metodą zol-żel otrzymuje się cząsteczki krzemionkowe sfunkcjonalizowane grupami aminowymi, b) cząstki krzemionkowe sfunkcjonalizowane grupami aminowymi otrzymane w etapie a) zawiesza się w zolu zawierającym mieszaninę roztworów kolagenu, chitozanu i kwasu hialuronowego, korzystnie w stosunku wagowym kolagen : chitosan : kwas hialuronowy wynoszącym 50 : 40 : 10, przy czym korzystnie zawartość sfunkcjonalizowanych cząsteczek krzemionkowych w zolu wynosi nie mniej niż 1,9 mg/ml zolu, korzystnie od 1,9 do 3,8 mg/ml zolu, c) uzyskaną w etapie b) zawiesinę poddaje się reakcji sieciowania genipiną. Zgłoszenie obejmuje, ponadto hydrożelowy materiał otrzymany powyższym sposobem.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL428993A PL239179B1 (pl) | 2019-02-21 | 2019-02-21 | Hydrożelowy materiał hybrydowy oraz sposób jego otrzymywania i zastosowanie |
| ES20754841T ES2973340T3 (es) | 2019-02-21 | 2020-02-21 | Material híbrido de hidrogel, método de su preparación y aplicación |
| PCT/PL2020/050019 WO2020171723A2 (en) | 2019-02-21 | 2020-02-21 | Hydrogel hybrid material, method of its preparation and application |
| US17/426,629 US20220047776A1 (en) | 2019-02-21 | 2020-02-21 | Hydrogel hybrid material, method of its preparation and application |
| EP20754841.3A EP3927387B1 (en) | 2019-02-21 | 2020-02-21 | Hydrogel hybrid material, method of its preparation and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL428993A PL239179B1 (pl) | 2019-02-21 | 2019-02-21 | Hydrożelowy materiał hybrydowy oraz sposób jego otrzymywania i zastosowanie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL428993A1 true PL428993A1 (pl) | 2020-08-24 |
| PL239179B1 PL239179B1 (pl) | 2021-11-08 |
Family
ID=72050910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL428993A PL239179B1 (pl) | 2019-02-21 | 2019-02-21 | Hydrożelowy materiał hybrydowy oraz sposób jego otrzymywania i zastosowanie |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220047776A1 (pl) |
| EP (1) | EP3927387B1 (pl) |
| ES (1) | ES2973340T3 (pl) |
| PL (1) | PL239179B1 (pl) |
| WO (1) | WO2020171723A2 (pl) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022045910A1 (en) | 2020-08-26 | 2022-03-03 | Uniwersytet Jagielloński | Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses |
| PL441996A1 (pl) * | 2022-08-11 | 2024-02-12 | Uniwersytet Jagielloński | Wielofunkcyjny, hydrożelowy materiał hybrydowy, w szczególności do stosowania w leczeniu ubytków kostnych oraz sposób jego otrzymywania |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188746B (zh) * | 2010-03-11 | 2013-08-14 | 北京益而康生物工程开发中心 | 人工细胞外基质及其应用 |
-
2019
- 2019-02-21 PL PL428993A patent/PL239179B1/pl unknown
-
2020
- 2020-02-21 EP EP20754841.3A patent/EP3927387B1/en active Active
- 2020-02-21 ES ES20754841T patent/ES2973340T3/es active Active
- 2020-02-21 WO PCT/PL2020/050019 patent/WO2020171723A2/en unknown
- 2020-02-21 US US17/426,629 patent/US20220047776A1/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022045910A1 (en) | 2020-08-26 | 2022-03-03 | Uniwersytet Jagielloński | Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses |
| PL441996A1 (pl) * | 2022-08-11 | 2024-02-12 | Uniwersytet Jagielloński | Wielofunkcyjny, hydrożelowy materiał hybrydowy, w szczególności do stosowania w leczeniu ubytków kostnych oraz sposób jego otrzymywania |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020171723A2 (en) | 2020-08-27 |
| EP3927387B1 (en) | 2023-12-06 |
| WO2020171723A3 (en) | 2020-10-22 |
| US20220047776A1 (en) | 2022-02-17 |
| PL239179B1 (pl) | 2021-11-08 |
| EP3927387A2 (en) | 2021-12-29 |
| ES2973340T3 (es) | 2024-06-19 |
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