PL428993A1 - Hydrożelowy materiał hybrydowy, sposób jego otrzymywania i zastosowanie - Google Patents

Hydrożelowy materiał hybrydowy, sposób jego otrzymywania i zastosowanie

Info

Publication number
PL428993A1
PL428993A1 PL428993A PL42899319A PL428993A1 PL 428993 A1 PL428993 A1 PL 428993A1 PL 428993 A PL428993 A PL 428993A PL 42899319 A PL42899319 A PL 42899319A PL 428993 A1 PL428993 A1 PL 428993A1
Authority
PL
Poland
Prior art keywords
sol
application
silica particles
hybrid material
functionalized silica
Prior art date
Application number
PL428993A
Other languages
English (en)
Other versions
PL239179B1 (pl
Inventor
Maria Nowakowska
Joanna Lewandowska-Łańcucka
Adriana GILARSKA
Original Assignee
Uniwersytet Jagielloński
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Jagielloński filed Critical Uniwersytet Jagielloński
Priority to PL428993A priority Critical patent/PL239179B1/pl
Priority to EP20754841.3A priority patent/EP3927387B1/en
Priority to ES20754841T priority patent/ES2973340T3/es
Priority to PCT/PL2020/050019 priority patent/WO2020171723A2/en
Priority to US17/426,629 priority patent/US12447235B2/en
Publication of PL428993A1 publication Critical patent/PL428993A1/pl
Publication of PL239179B1 publication Critical patent/PL239179B1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/28—Compounds of silicon
    • C09C1/30—Silicic acid
    • C09C1/3063—Treatment with low-molecular organic compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C3/00—Treatment in general of inorganic materials, other than fibrous fillers, to enhance their pigmenting or filling properties
    • C09C3/08—Treatment with low-molecular-weight non-polymer organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania hydrożelowego materiału hybrydowego, charakteryzujący się tym, że obejmuje następujące etapy: a) metodą zol-żel otrzymuje się cząsteczki krzemionkowe sfunkcjonalizowane grupami aminowymi, b) cząstki krzemionkowe sfunkcjonalizowane grupami aminowymi otrzymane w etapie a) zawiesza się w zolu zawierającym mieszaninę roztworów kolagenu, chitozanu i kwasu hialuronowego, korzystnie w stosunku wagowym kolagen : chitosan : kwas hialuronowy wynoszącym 50 : 40 : 10, przy czym korzystnie zawartość sfunkcjonalizowanych cząsteczek krzemionkowych w zolu wynosi nie mniej niż 1,9 mg/ml zolu, korzystnie od 1,9 do 3,8 mg/ml zolu, c) uzyskaną w etapie b) zawiesinę poddaje się reakcji sieciowania genipiną. Zgłoszenie obejmuje, ponadto hydrożelowy materiał otrzymany powyższym sposobem.
PL428993A 2019-02-21 2019-02-21 Hydrożelowy materiał hybrydowy oraz sposób jego otrzymywania i zastosowanie PL239179B1 (pl)

Priority Applications (5)

Application Number Priority Date Filing Date Title
PL428993A PL239179B1 (pl) 2019-02-21 2019-02-21 Hydrożelowy materiał hybrydowy oraz sposób jego otrzymywania i zastosowanie
EP20754841.3A EP3927387B1 (en) 2019-02-21 2020-02-21 Hydrogel hybrid material, method of its preparation and application
ES20754841T ES2973340T3 (es) 2019-02-21 2020-02-21 Material híbrido de hidrogel, método de su preparación y aplicación
PCT/PL2020/050019 WO2020171723A2 (en) 2019-02-21 2020-02-21 Hydrogel hybrid material, method of its preparation and application
US17/426,629 US12447235B2 (en) 2019-02-21 2020-02-21 Hydrogel hybrid material, method of its preparation and application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL428993A PL239179B1 (pl) 2019-02-21 2019-02-21 Hydrożelowy materiał hybrydowy oraz sposób jego otrzymywania i zastosowanie

Publications (2)

Publication Number Publication Date
PL428993A1 true PL428993A1 (pl) 2020-08-24
PL239179B1 PL239179B1 (pl) 2021-11-08

Family

ID=72050910

Family Applications (1)

Application Number Title Priority Date Filing Date
PL428993A PL239179B1 (pl) 2019-02-21 2019-02-21 Hydrożelowy materiał hybrydowy oraz sposób jego otrzymywania i zastosowanie

Country Status (5)

Country Link
US (1) US12447235B2 (pl)
EP (1) EP3927387B1 (pl)
ES (1) ES2973340T3 (pl)
PL (1) PL239179B1 (pl)
WO (1) WO2020171723A2 (pl)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022045910A1 (en) 2020-08-26 2022-03-03 Uniwersytet Jagielloński Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses
PL441996A1 (pl) * 2022-08-11 2024-02-12 Uniwersytet Jagielloński Wielofunkcyjny, hydrożelowy materiał hybrydowy, w szczególności do stosowania w leczeniu ubytków kostnych oraz sposób jego otrzymywania

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102882738B1 (ko) * 2022-10-13 2025-11-07 연세대학교 산학협력단 자가 치유 하이드로겔 및 이의 용도
PL446217A1 (pl) * 2023-09-25 2025-03-31 Uniwersytet Jagielloński Kompozycja zawierająca bioaktywny hydrożel oraz sposób jej otrzymywania
CN117959771A (zh) * 2024-01-30 2024-05-03 徐露阳 一种血液分离胶及其制备方法
CN121868147A (zh) * 2026-01-26 2026-04-17 中国人民解放军总医院第一医学中心 牙体牙髓科根管充填用抗菌型复合树脂基充填材料

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102188746B (zh) 2010-03-11 2013-08-14 北京益而康生物工程开发中心 人工细胞外基质及其应用

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022045910A1 (en) 2020-08-26 2022-03-03 Uniwersytet Jagielloński Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses
US20230310714A1 (en) * 2020-08-26 2023-10-05 Uniwersytet Jagiellonski Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses
US12661432B2 (en) * 2020-08-26 2026-06-23 Uniwersytet Jagielloński Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses
PL441996A1 (pl) * 2022-08-11 2024-02-12 Uniwersytet Jagielloński Wielofunkcyjny, hydrożelowy materiał hybrydowy, w szczególności do stosowania w leczeniu ubytków kostnych oraz sposób jego otrzymywania
PL247558B1 (pl) * 2022-08-11 2025-07-28 Univ Jagiellonski Wielofunkcyjny, hydrożelowy materiał hybrydowy, w szczególności do stosowania w leczeniu ubytków kostnych oraz sposób jego otrzymywania

Also Published As

Publication number Publication date
ES2973340T3 (es) 2024-06-19
US12447235B2 (en) 2025-10-21
PL239179B1 (pl) 2021-11-08
WO2020171723A2 (en) 2020-08-27
EP3927387B1 (en) 2023-12-06
WO2020171723A3 (en) 2020-10-22
EP3927387A2 (en) 2021-12-29
US20220047776A1 (en) 2022-02-17

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