PL422406A1 - 3'-Amino-4-carboxychalcone and method for obtaining 3'-amino-4-carboxychalcone - Google Patents
3'-Amino-4-carboxychalcone and method for obtaining 3'-amino-4-carboxychalconeInfo
- Publication number
- PL422406A1 PL422406A1 PL422406A PL42240617A PL422406A1 PL 422406 A1 PL422406 A1 PL 422406A1 PL 422406 A PL422406 A PL 422406A PL 42240617 A PL42240617 A PL 42240617A PL 422406 A1 PL422406 A1 PL 422406A1
- Authority
- PL
- Poland
- Prior art keywords
- carboxychalcone
- amino
- substrate
- mixture
- obtaining
- Prior art date
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Przedmiotem zgłoszenia jest 3'-amino-4-karboksychalkon o wzorze 3 oraz sposób jego otrzymywania. Sposób ten polega na tym, że do mieszaniny wody i alkoholu dodaje się wodorotlenek o charakterze zasadowym, a następnie substrat, którym jest kwas 4-formylobenzaldehydowy oraz drugi substrat, którym jest 3'-aminoacetofenon, co stanowi mieszaninę reakcyjną, którą pozostawia się w temperaturze od 0°C do 4°C na okres od 0,5 do 2 godzin przy ciągłym mieszaniu, po czym do przereagowanej mieszaniny dodaje się kwasu solnego do osiągnięcia pH bliskiego 7,0, a otrzymany osad sączy się pod zmniejszonym ciśnieniem, następnie surowy produkt oczyszcza się.The subject of the application is 3'-amino-4-carboxychalcone of formula 3 and the method of its preparation. The method consists in adding basic hydroxide to the water and alcohol mixture, followed by a substrate which is 4-formylbenzaldehyde and a second substrate which is 3'-aminoacetophenone, which is a reaction mixture that is left at from 0 ° C to 4 ° C for 0.5 to 2 hours with continuous stirring, then hydrochloric acid is added to the reacted mixture to reach a pH close to 7.0, and the resulting precipitate is filtered under reduced pressure, then the crude product cleanses itself.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL422406A PL232667B1 (en) | 2017-07-31 | 2017-07-31 | 3'-Amino-4-carboxychalcone and method for obtaining 3'-amino-4-carboxychalcone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL422406A PL232667B1 (en) | 2017-07-31 | 2017-07-31 | 3'-Amino-4-carboxychalcone and method for obtaining 3'-amino-4-carboxychalcone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL422406A1 true PL422406A1 (en) | 2019-02-11 |
| PL232667B1 PL232667B1 (en) | 2019-07-31 |
Family
ID=65270276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL422406A PL232667B1 (en) | 2017-07-31 | 2017-07-31 | 3'-Amino-4-carboxychalcone and method for obtaining 3'-amino-4-carboxychalcone |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL232667B1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1044251A (en) * | 1973-10-30 | 1978-12-12 | Katsuo Hatayama | Anti-gastric ulcer chalcone ethers |
| WO2003053368A2 (en) * | 2001-12-19 | 2003-07-03 | Atherogenics, Inc. | Chalcone derivatives and their use to treat diseases |
| EP2601943A1 (en) * | 2006-12-07 | 2013-06-12 | Seoul National University Industry Foundation | Anti-cancer composition containing chalcone compounds |
| KR20160137156A (en) * | 2015-05-22 | 2016-11-30 | 재단법인 경기과학기술진흥원 | Method for preparing chalcone or its derivatives |
-
2017
- 2017-07-31 PL PL422406A patent/PL232667B1/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1044251A (en) * | 1973-10-30 | 1978-12-12 | Katsuo Hatayama | Anti-gastric ulcer chalcone ethers |
| WO2003053368A2 (en) * | 2001-12-19 | 2003-07-03 | Atherogenics, Inc. | Chalcone derivatives and their use to treat diseases |
| EP2601943A1 (en) * | 2006-12-07 | 2013-06-12 | Seoul National University Industry Foundation | Anti-cancer composition containing chalcone compounds |
| KR20160137156A (en) * | 2015-05-22 | 2016-11-30 | 재단법인 경기과학기술진흥원 | Method for preparing chalcone or its derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| PL232667B1 (en) | 2019-07-31 |
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