PL422407A1 - 2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone - Google Patents

2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone

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Publication number
PL422407A1
PL422407A1 PL422407A PL42240717A PL422407A1 PL 422407 A1 PL422407 A1 PL 422407A1 PL 422407 A PL422407 A PL 422407A PL 42240717 A PL42240717 A PL 42240717A PL 422407 A1 PL422407 A1 PL 422407A1
Authority
PL
Poland
Prior art keywords
carboxychalcone
amino
formula
substrate
reaction mixture
Prior art date
Application number
PL422407A
Other languages
Polish (pl)
Other versions
PL232668B1 (en
Inventor
Joanna Kozłowska
Mirosław Anioł
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL422407A priority Critical patent/PL232668B1/en
Publication of PL422407A1 publication Critical patent/PL422407A1/en
Publication of PL232668B1 publication Critical patent/PL232668B1/en

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Abstract

Przedmiotem zgłoszenia jest 2'-amino-4-karboksychalkon o wzorze 3 i sposób jest otrzymywania, który polega na tym, że do mieszaniny wody i alkoholu dodaje się wodorotlenek o charakterze zasadowym, a następnie substrat, którym jest kwas 4-formylobenzaldehydowy o wzorze 2 oraz drugi substrat, którym jest 2'-aminoacetofenon o wzorze 1, co stanowi mieszaninę reakcyjną, którą pozostawia się w temperaturze od 20°C do 28°C na okres od 15 do 18 godzin przy ciągłym mieszaniu, po czym do przereagowanej mieszaniny dodaje się kwasu solnego do osiągnięcia pH bliskiego 7,0, a otrzymany osad sączy się pod zmniejszonym ciśnieniem.The subject of the application is 2'-amino-4-carboxychalcone of formula 3 and the method is a preparation, which consists in adding basic hydroxide to a water-alcohol mixture followed by a substrate which is 4-formylbenzaldehyde of formula 2 and a second substrate, which is 2'-aminoacetophenone of formula 1, which is a reaction mixture which is left at a temperature of 20 ° C to 28 ° C for 15 to 18 hours with constant stirring, after which the reaction mixture is added hydrochloric acid to reach a pH close to 7.0, and the resulting precipitate is filtered under reduced pressure.

PL422407A 2017-07-31 2017-07-31 2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone PL232668B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL422407A PL232668B1 (en) 2017-07-31 2017-07-31 2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL422407A PL232668B1 (en) 2017-07-31 2017-07-31 2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone

Publications (2)

Publication Number Publication Date
PL422407A1 true PL422407A1 (en) 2019-02-11
PL232668B1 PL232668B1 (en) 2019-07-31

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PL422407A PL232668B1 (en) 2017-07-31 2017-07-31 2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone

Country Status (1)

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PL (1) PL232668B1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1044251A (en) * 1973-10-30 1978-12-12 Katsuo Hatayama Anti-gastric ulcer chalcone ethers
WO2003053368A2 (en) * 2001-12-19 2003-07-03 Atherogenics, Inc. Chalcone derivatives and their use to treat diseases
EP2601943A1 (en) * 2006-12-07 2013-06-12 Seoul National University Industry Foundation Anti-cancer composition containing chalcone compounds
KR20160137156A (en) * 2015-05-22 2016-11-30 재단법인 경기과학기술진흥원 Method for preparing chalcone or its derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1044251A (en) * 1973-10-30 1978-12-12 Katsuo Hatayama Anti-gastric ulcer chalcone ethers
WO2003053368A2 (en) * 2001-12-19 2003-07-03 Atherogenics, Inc. Chalcone derivatives and their use to treat diseases
EP2601943A1 (en) * 2006-12-07 2013-06-12 Seoul National University Industry Foundation Anti-cancer composition containing chalcone compounds
KR20160137156A (en) * 2015-05-22 2016-11-30 재단법인 경기과학기술진흥원 Method for preparing chalcone or its derivatives

Also Published As

Publication number Publication date
PL232668B1 (en) 2019-07-31

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