PL422407A1 - 2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone - Google Patents
2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalconeInfo
- Publication number
- PL422407A1 PL422407A1 PL422407A PL42240717A PL422407A1 PL 422407 A1 PL422407 A1 PL 422407A1 PL 422407 A PL422407 A PL 422407A PL 42240717 A PL42240717 A PL 42240717A PL 422407 A1 PL422407 A1 PL 422407A1
- Authority
- PL
- Poland
- Prior art keywords
- carboxychalcone
- amino
- formula
- substrate
- reaction mixture
- Prior art date
Links
Abstract
Przedmiotem zgłoszenia jest 2'-amino-4-karboksychalkon o wzorze 3 i sposób jest otrzymywania, który polega na tym, że do mieszaniny wody i alkoholu dodaje się wodorotlenek o charakterze zasadowym, a następnie substrat, którym jest kwas 4-formylobenzaldehydowy o wzorze 2 oraz drugi substrat, którym jest 2'-aminoacetofenon o wzorze 1, co stanowi mieszaninę reakcyjną, którą pozostawia się w temperaturze od 20°C do 28°C na okres od 15 do 18 godzin przy ciągłym mieszaniu, po czym do przereagowanej mieszaniny dodaje się kwasu solnego do osiągnięcia pH bliskiego 7,0, a otrzymany osad sączy się pod zmniejszonym ciśnieniem.The subject of the application is 2'-amino-4-carboxychalcone of formula 3 and the method is a preparation, which consists in adding basic hydroxide to a water-alcohol mixture followed by a substrate which is 4-formylbenzaldehyde of formula 2 and a second substrate, which is 2'-aminoacetophenone of formula 1, which is a reaction mixture which is left at a temperature of 20 ° C to 28 ° C for 15 to 18 hours with constant stirring, after which the reaction mixture is added hydrochloric acid to reach a pH close to 7.0, and the resulting precipitate is filtered under reduced pressure.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL422407A PL232668B1 (en) | 2017-07-31 | 2017-07-31 | 2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL422407A PL232668B1 (en) | 2017-07-31 | 2017-07-31 | 2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone |
Publications (2)
Publication Number | Publication Date |
---|---|
PL422407A1 true PL422407A1 (en) | 2019-02-11 |
PL232668B1 PL232668B1 (en) | 2019-07-31 |
Family
ID=65270253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL422407A PL232668B1 (en) | 2017-07-31 | 2017-07-31 | 2'-Amino-4-carboxychalcone and method for obtaining 2'-amino-4-carboxychalcone |
Country Status (1)
Country | Link |
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PL (1) | PL232668B1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1044251A (en) * | 1973-10-30 | 1978-12-12 | Katsuo Hatayama | Anti-gastric ulcer chalcone ethers |
WO2003053368A2 (en) * | 2001-12-19 | 2003-07-03 | Atherogenics, Inc. | Chalcone derivatives and their use to treat diseases |
EP2601943A1 (en) * | 2006-12-07 | 2013-06-12 | Seoul National University Industry Foundation | Anti-cancer composition containing chalcone compounds |
KR20160137156A (en) * | 2015-05-22 | 2016-11-30 | 재단법인 경기과학기술진흥원 | Method for preparing chalcone or its derivatives |
-
2017
- 2017-07-31 PL PL422407A patent/PL232668B1/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1044251A (en) * | 1973-10-30 | 1978-12-12 | Katsuo Hatayama | Anti-gastric ulcer chalcone ethers |
WO2003053368A2 (en) * | 2001-12-19 | 2003-07-03 | Atherogenics, Inc. | Chalcone derivatives and their use to treat diseases |
EP2601943A1 (en) * | 2006-12-07 | 2013-06-12 | Seoul National University Industry Foundation | Anti-cancer composition containing chalcone compounds |
KR20160137156A (en) * | 2015-05-22 | 2016-11-30 | 재단법인 경기과학기술진흥원 | Method for preparing chalcone or its derivatives |
Also Published As
Publication number | Publication date |
---|---|
PL232668B1 (en) | 2019-07-31 |
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