PL406524A1 - Sposób otrzymywania wardenafilu i jego soli - Google Patents
Sposób otrzymywania wardenafilu i jego soliInfo
- Publication number
- PL406524A1 PL406524A1 PL406524A PL40652413A PL406524A1 PL 406524 A1 PL406524 A1 PL 406524A1 PL 406524 A PL406524 A PL 406524A PL 40652413 A PL40652413 A PL 40652413A PL 406524 A1 PL406524 A1 PL 406524A1
- Authority
- PL
- Poland
- Prior art keywords
- vardenafil
- monohydrochloride
- obtaining
- base
- triazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Abstract
Ujawniono sposób otrzymywania zasady wardenafilu, w bezwodnych warunkach, przez chlorosulfonowanie 2-(2-etoksy-fenylo)-5-metylo-7-propylo-3H-imidazo[5,1-f][1,2,4]triazyn-4-onu w mieszaninie chlorku tionylu i kwasu chlorosulfonowego, a następnie amidowanie powstałego chlorku kwasu 4-etoksy-3-(5-metylo-4-okso-7-propylo-3,4-dihydroimidazo[5,1-f][1,2,4]-triazyn-2-ylo)benzeno-sulfonowego N-etylopiperazyną, w rozpuszczalniku aprotycznym, w obecności nieorganicznej zasady oraz sposób przeprowadzania otrzymanej zasady wardenafilu w trójwodzian monochlorowodorku wardenafilu o temperaturze topnienia 234°C przez kontaktowanie z wodą bezwodnej modyfikacji V monochlorowodorku wardenafilu w rozpuszczalniku organicznym. Przedmiotem wynalazku jest również bezwodna modyfikacja V monochlorowodorku wardenafilu oraz jej zastosowanie do otrzymywania trójwodzianu monochlorowodorku wardenafilu o temperaturze topnienia 234°C.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL406524A PL223869B1 (pl) | 2013-12-16 | 2013-12-16 | Sposób otrzymywania wardenafilu i jego soli |
EA201600466A EA032040B1 (ru) | 2013-12-16 | 2014-12-08 | Способ получения варденафила и его солей |
HUE14827879A HUE055214T2 (hu) | 2013-12-16 | 2014-12-08 | Eljárás vardenafilnak és sóinak elkészítésére |
ES14827879T ES2866627T3 (es) | 2013-12-16 | 2014-12-08 | Método para fabricar vardenafilo y sus sales |
PCT/PL2014/000135 WO2015093994A1 (en) | 2013-12-16 | 2014-12-08 | The method for manufacturing of vardenafil and its salts |
EP14827879.9A EP3083629B1 (en) | 2013-12-16 | 2014-12-08 | The method for manufacturing of vardenafil and its salts |
US15/104,285 US9845328B2 (en) | 2013-12-16 | 2014-12-08 | Method for manufacturing of vardenafil and its salts |
HRP20210594TT HRP20210594T1 (hr) | 2013-12-16 | 2021-04-14 | Postupak za proizvodnju vardenafila i njegovih soli |
CY20211100531T CY1124259T1 (el) | 2013-12-16 | 2021-06-14 | Μεθοδος για παρασκευη βαρδεναφιλης και αλατων αυτης |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL406524A PL223869B1 (pl) | 2013-12-16 | 2013-12-16 | Sposób otrzymywania wardenafilu i jego soli |
Publications (2)
Publication Number | Publication Date |
---|---|
PL406524A1 true PL406524A1 (pl) | 2015-06-22 |
PL223869B1 PL223869B1 (pl) | 2016-11-30 |
Family
ID=52355157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL406524A PL223869B1 (pl) | 2013-12-16 | 2013-12-16 | Sposób otrzymywania wardenafilu i jego soli |
Country Status (9)
Country | Link |
---|---|
US (1) | US9845328B2 (pl) |
EP (1) | EP3083629B1 (pl) |
CY (1) | CY1124259T1 (pl) |
EA (1) | EA032040B1 (pl) |
ES (1) | ES2866627T3 (pl) |
HR (1) | HRP20210594T1 (pl) |
HU (1) | HUE055214T2 (pl) |
PL (1) | PL223869B1 (pl) |
WO (1) | WO2015093994A1 (pl) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE213246T1 (de) * | 1997-11-12 | 2002-02-15 | 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren | |
DE10063108A1 (de) * | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
CN100360531C (zh) * | 2003-12-18 | 2008-01-09 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物 |
US7977478B2 (en) * | 2006-03-13 | 2011-07-12 | Dr. Reddy's Laboratories Limited | Polymorphic forms of vardenafil |
CZ303877B6 (cs) | 2011-11-24 | 2013-06-05 | Zentiva, K.S. | Zpusob prípravy a izolace solí vardenafilu s kyselinami |
-
2013
- 2013-12-16 PL PL406524A patent/PL223869B1/pl unknown
-
2014
- 2014-12-08 WO PCT/PL2014/000135 patent/WO2015093994A1/en active Application Filing
- 2014-12-08 EA EA201600466A patent/EA032040B1/ru not_active IP Right Cessation
- 2014-12-08 HU HUE14827879A patent/HUE055214T2/hu unknown
- 2014-12-08 US US15/104,285 patent/US9845328B2/en not_active Expired - Fee Related
- 2014-12-08 ES ES14827879T patent/ES2866627T3/es active Active
- 2014-12-08 EP EP14827879.9A patent/EP3083629B1/en active Active
-
2021
- 2021-04-14 HR HRP20210594TT patent/HRP20210594T1/hr unknown
- 2021-06-14 CY CY20211100531T patent/CY1124259T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EA032040B1 (ru) | 2019-03-29 |
ES2866627T3 (es) | 2021-10-19 |
CY1124259T1 (el) | 2022-07-22 |
EP3083629B1 (en) | 2021-03-31 |
EA201600466A1 (ru) | 2017-03-31 |
HRP20210594T1 (hr) | 2021-06-11 |
US9845328B2 (en) | 2017-12-19 |
WO2015093994A1 (en) | 2015-06-25 |
EP3083629A1 (en) | 2016-10-26 |
PL223869B1 (pl) | 2016-11-30 |
US20160311827A1 (en) | 2016-10-27 |
HUE055214T2 (hu) | 2021-11-29 |
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