PL3833434T3 - Związki przydatne w modulowaniu receptora farnezoidalnego x oraz sposoby jego wytwarzania i stosowania - Google Patents
Związki przydatne w modulowaniu receptora farnezoidalnego x oraz sposoby jego wytwarzania i stosowaniaInfo
- Publication number
- PL3833434T3 PL3833434T3 PL19759119T PL19759119T PL3833434T3 PL 3833434 T3 PL3833434 T3 PL 3833434T3 PL 19759119 T PL19759119 T PL 19759119T PL 19759119 T PL19759119 T PL 19759119T PL 3833434 T3 PL3833434 T3 PL 3833434T3
- Authority
- PL
- Poland
- Prior art keywords
- farnesoid
- modulating
- receptor
- making
- methods
- Prior art date
Links
- 102100038495 Bile acid receptor Human genes 0.000 title 1
- 101000603876 Homo sapiens Bile acid receptor Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862716015P | 2018-08-08 | 2018-08-08 | |
| PCT/US2019/045266 WO2020033382A1 (en) | 2018-08-08 | 2019-08-06 | Compounds useful in modulating the farnesoid x receptor and methods of making and using the same |
| EP19759119.1A EP3833434B1 (en) | 2018-08-08 | 2019-08-06 | Compounds useful in modulating the farnesoid x receptor and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3833434T3 true PL3833434T3 (pl) | 2022-03-07 |
Family
ID=67766286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19759119T PL3833434T3 (pl) | 2018-08-08 | 2019-08-06 | Związki przydatne w modulowaniu receptora farnezoidalnego x oraz sposoby jego wytwarzania i stosowania |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11339153B2 (pl) |
| EP (2) | EP3833434B1 (pl) |
| JP (1) | JP7457020B2 (pl) |
| KR (2) | KR20220087471A (pl) |
| CN (1) | CN112638473B (pl) |
| AU (1) | AU2019319750A1 (pl) |
| BR (1) | BR112021002050A2 (pl) |
| CA (1) | CA3106033A1 (pl) |
| DK (1) | DK3833434T3 (pl) |
| ES (1) | ES2907187T3 (pl) |
| IL (1) | IL280520B2 (pl) |
| MX (1) | MX2021001513A (pl) |
| PH (1) | PH12021550214A1 (pl) |
| PL (1) | PL3833434T3 (pl) |
| SA (1) | SA521421189B1 (pl) |
| WO (1) | WO2020033382A1 (pl) |
| ZA (1) | ZA202101119B (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250113526A (ko) | 2018-03-22 | 2025-07-25 | 바이킹 테라퓨틱스 인코포레이티드 | 결정질 형태, 및 결정질 형태의 화합물을 제조하는 방법 |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| EP4106746A1 (en) * | 2020-02-11 | 2022-12-28 | Inorbit Therapeutics Ab | Farnesoid x receptor modulating compounds and methods of using the same |
| WO2021252392A1 (en) * | 2020-06-09 | 2021-12-16 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of liver disorders |
| CN114656460B (zh) | 2020-12-22 | 2025-01-10 | 江苏天士力帝益药业有限公司 | 一种新型吡嗪结构fxr激动剂、制备方法及应用 |
| CN117043160B (zh) * | 2021-02-27 | 2024-08-30 | 轩竹生物科技股份有限公司 | Fxr受体激动剂的晶型 |
| CN115504972B (zh) * | 2021-06-22 | 2024-11-12 | 广东药科大学 | 异恶唑类衍生物、其制备方法及其作为药物的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51125741A (en) * | 1974-10-17 | 1976-11-02 | Chevron Res | Weed killer |
| EP2289883A1 (en) | 2009-08-19 | 2011-03-02 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| CU24152B1 (es) | 2010-12-20 | 2016-02-29 | Irm Llc | 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| EP3034501A1 (en) | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Hydroxy containing FXR (NR1H4) modulating compounds |
| EP3034499A1 (en) | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Novel FXR (NR1H4) modulating compounds |
| AR108711A1 (es) * | 2016-06-13 | 2018-09-19 | Gilead Sciences Inc | Compuestos moduladores de fxr (nr1h4) |
| MA46052A (fr) | 2016-08-23 | 2021-03-17 | Ardelyx Inc | Modulateurs du récepteur hormonal pour le traitement d'états et de troubles métaboliques |
| CN107973790A (zh) | 2016-10-22 | 2018-05-01 | 合帕吉恩治疗公司 | 杂环fxr调节剂 |
| CN108218852A (zh) * | 2016-12-15 | 2018-06-29 | 宁波百纳西药业有限公司 | 一种螺环化合物、其制备方法、组合物及用途 |
-
2019
- 2019-08-06 CA CA3106033A patent/CA3106033A1/en active Pending
- 2019-08-06 JP JP2021531453A patent/JP7457020B2/ja active Active
- 2019-08-06 US US17/265,266 patent/US11339153B2/en active Active
- 2019-08-06 KR KR1020227015903A patent/KR20220087471A/ko not_active Ceased
- 2019-08-06 DK DK19759119.1T patent/DK3833434T3/da active
- 2019-08-06 EP EP19759119.1A patent/EP3833434B1/en active Active
- 2019-08-06 AU AU2019319750A patent/AU2019319750A1/en not_active Abandoned
- 2019-08-06 PL PL19759119T patent/PL3833434T3/pl unknown
- 2019-08-06 BR BR112021002050-0A patent/BR112021002050A2/pt unknown
- 2019-08-06 CN CN201980053552.XA patent/CN112638473B/zh active Active
- 2019-08-06 WO PCT/US2019/045266 patent/WO2020033382A1/en not_active Ceased
- 2019-08-06 EP EP21209598.8A patent/EP3981467A1/en not_active Withdrawn
- 2019-08-06 ES ES19759119T patent/ES2907187T3/es active Active
- 2019-08-06 IL IL280520A patent/IL280520B2/en unknown
- 2019-08-06 MX MX2021001513A patent/MX2021001513A/es unknown
- 2019-08-06 KR KR1020217005059A patent/KR102398656B1/ko active Active
-
2021
- 2021-01-28 PH PH12021550214A patent/PH12021550214A1/en unknown
- 2021-02-04 SA SA521421189A patent/SA521421189B1/ar unknown
- 2021-02-18 ZA ZA2021/01119A patent/ZA202101119B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11339153B2 (en) | 2022-05-24 |
| IL280520B2 (en) | 2023-11-01 |
| WO2020033382A1 (en) | 2020-02-13 |
| KR20220087471A (ko) | 2022-06-24 |
| CA3106033A1 (en) | 2020-02-13 |
| CN112638473A (zh) | 2021-04-09 |
| KR102398656B1 (ko) | 2022-05-16 |
| EP3833434B1 (en) | 2021-12-15 |
| ES2907187T3 (es) | 2022-04-22 |
| CN112638473B (zh) | 2022-06-07 |
| JP7457020B2 (ja) | 2024-03-27 |
| KR20210042112A (ko) | 2021-04-16 |
| ZA202101119B (en) | 2022-09-28 |
| SA521421189B1 (ar) | 2023-11-08 |
| MX2021001513A (es) | 2021-06-15 |
| IL280520A (en) | 2021-03-01 |
| PH12021550214A1 (en) | 2021-10-18 |
| JP2021534238A (ja) | 2021-12-09 |
| EP3981467A1 (en) | 2022-04-13 |
| US20210309656A1 (en) | 2021-10-07 |
| BR112021002050A2 (pt) | 2021-05-04 |
| EP3833434A1 (en) | 2021-06-16 |
| AU2019319750A1 (en) | 2021-03-04 |
| DK3833434T3 (da) | 2022-02-14 |
| IL280520B1 (en) | 2023-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202101119B (en) | Compounds useful in modulating the farnesoid x receptor and methods of making and using the same | |
| IL287720A (en) | modulators of thr-in the cell and methods of using them | |
| IL276277A (en) | Anti-CTLA4 antibodies and methods for their preparation and use | |
| IL277079A (en) | Cartirin preparations and methods of use | |
| SG11202103325WA (en) | Androgen receptor modulators and methods for their use | |
| IL280709A (en) | Converted indoles and methods of using them | |
| IL291029A (en) | New modulators of 5-hydroxytryptamine receptor 7 and a method of using them | |
| GB201810364D0 (en) | Joint pieces and rectangular joint structures | |
| IL277212A (en) | Anti-KLK5 antibodies and methods of use | |
| IL276187B1 (en) | Mica/b antibodies and methods of use | |
| IL282708A (en) | Anti-tim-3 antibodies and their use | |
| IL282707A (en) | Anti-tim-3 antibodies and their use | |
| EP3600290C0 (en) | NOVEL SIGMA 2 RECEPTOR MODULATORS AND METHOD OF USE THEREOF | |
| PL3829310T3 (pl) | Kompozycje agrochemiczne oraz sposoby ich wytwarzania i zastosowania | |
| EP3426643A4 (en) | AMINO ACYCLIC HYDROFLUOROETHERS AND METHODS OF USE | |
| EP3724293A4 (en) | ASPHALT COMPOSITIONS AND THEIR METHODS OF USE | |
| IL271982A (en) | Antigen binding sites against type III fibronectin sites and methods of using them | |
| IL283231A (en) | dpep-1 binding factors and methods of use | |
| GB201705455D0 (en) | paving and tiling apparatus | |
| GB201911462D0 (en) | Liquid crystal composition and method | |
| IL286946A (en) | enpp1 polypeptides and methods of using them | |
| GB201911130D0 (en) | MAterials and methods | |
| HK40055001A (en) | Compounds useful in modulating the farnesoid x receptor and methods of making and using the same | |
| ZA202100424B (en) | Colloidal barrier materials and methods of making and using the same | |
| GB201911629D0 (en) | Materials and methods |