PL377413A1 - Pochodne piryd-2-onu i sposoby ich zastosowania - Google Patents

Pochodne piryd-2-onu i sposoby ich zastosowania

Info

Publication number
PL377413A1
PL377413A1 PL377413A PL37741303A PL377413A1 PL 377413 A1 PL377413 A1 PL 377413A1 PL 377413 A PL377413 A PL 377413A PL 37741303 A PL37741303 A PL 37741303A PL 377413 A1 PL377413 A1 PL 377413A1
Authority
PL
Poland
Prior art keywords
pyrid
derivatives
methods
Prior art date
Application number
PL377413A
Other languages
English (en)
Inventor
Wenge Zhong
Mark Henry Norman
Matthew Kaller
Thomas Nguyen
Robert Michael Rzasa
Christopher Tegley
Hui-Ling Wang
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of PL377413A1 publication Critical patent/PL377413A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
PL377413A 2002-12-27 2003-12-22 Pochodne piryd-2-onu i sposoby ich zastosowania PL377413A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43678702P 2002-12-27 2002-12-27
US10/736,289 US20040147561A1 (en) 2002-12-27 2003-12-12 Pyrid-2-one derivatives and methods of use

Publications (1)

Publication Number Publication Date
PL377413A1 true PL377413A1 (pl) 2006-02-06

Family

ID=32738277

Family Applications (1)

Application Number Title Priority Date Filing Date
PL377413A PL377413A1 (pl) 2002-12-27 2003-12-22 Pochodne piryd-2-onu i sposoby ich zastosowania

Country Status (7)

Country Link
US (2) US20040147561A1 (pl)
EP (1) EP1575947A1 (pl)
JP (1) JP2006514059A (pl)
AU (1) AU2003299980A1 (pl)
CA (1) CA2509213A1 (pl)
PL (1) PL377413A1 (pl)
WO (1) WO2004060890A1 (pl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2587178A1 (en) * 2004-11-24 2006-06-01 Laboratoires Serono S.A. Novel 4-arylamino pyridone derivatives as mek inhibitors for the treatment of hyperproliferative disorders
RU2423351C2 (ru) * 2004-12-16 2011-07-10 Вертекс Фармасьютикалз Инкорпорейтед Пирид-2-оны, применимые как ингибиторы протеинкиназ семейства тес для лечения воспалительных, пролиферативных и иммунологически-опосредованных заболеваний
EP1741709A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
JP2009507792A (ja) * 2005-08-29 2009-02-26 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
MX2009007029A (es) 2006-12-28 2009-11-09 Mitsui Chemicals Agro Inc Derivado de acil-3-aminoacrilonitrilo 2-fluorado y metodo para producir el mismo.
EP2155705A4 (en) * 2007-06-08 2012-02-15 Univ Georgia State Res Found COMPOSITIONS FOR REGULATING OR MODULATING QUORUM DETECTION IN BACTERIA, METHODS OF USING THE SAME, AND METHODS OF REGULATING AND MODULATING QUORUM DETECTION IN BACTERIUM
WO2008156644A2 (en) * 2007-06-14 2008-12-24 Frank David A Stat modulators
MA33085B1 (fr) 2008-12-19 2012-03-01 Boehringer Ingelheim Int Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du recepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives
US8445517B2 (en) 2009-12-11 2013-05-21 Dana-Farber Cancer Institute Stat modulators
JP5632014B2 (ja) 2009-12-17 2014-11-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト及びこれらの使用
SG10201502484SA (en) 2010-03-30 2015-05-28 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
WO2011151251A1 (en) * 2010-06-01 2011-12-08 Boehringer Ingelheim International Gmbh New ccr2 antagonists
US20130281467A1 (en) 2010-10-28 2013-10-24 Syngenta Participations Ag Novel microbicides
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
MX2015012867A (es) 2013-03-15 2016-06-10 Verseon Corp Compuestos aromaticos multisustituidos como inhibidores de serina proteasa.
CN104013623B (zh) * 2014-05-28 2016-01-20 中山大学 氰基-吡啶类化合物在制备抗hiv-1病毒药物中的应用
CA2960790A1 (en) 2014-09-17 2016-03-24 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
EP3237385B1 (en) * 2014-12-22 2021-11-24 The United States of America, as represented by The Secretary, Department of Health and Human Services Mutant idh1 inhibitors useful for treating cancer
CN107405333A (zh) 2015-02-27 2017-11-28 维颂公司 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物
NZ738563A (en) * 2015-06-03 2019-09-27 Bristol Myers Squibb Co 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders
WO2017004537A1 (en) 2015-07-02 2017-01-05 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
CN110016023B (zh) * 2018-01-08 2020-05-08 新发药业有限公司 一种帕博西尼的简便制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE599556A (pl) * 1960-02-01
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone
CA2074933C (en) * 1990-11-30 2002-12-03 Masatoshi Chihiro Thiazole derivatives as active superoxide radical inhibitors
US6150359A (en) * 1997-08-20 2000-11-21 Warner-Lambert Company Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation
US20030055263A1 (en) * 2001-07-11 2003-03-20 Boehringer Ingelheim Pharma Kg Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production
WO2003027101A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation Substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles as c17,20 lyase inhibitors
US6822097B1 (en) * 2002-02-07 2004-11-23 Amgen, Inc. Compounds and methods of uses

Also Published As

Publication number Publication date
US20060241151A1 (en) 2006-10-26
AU2003299980A1 (en) 2004-07-29
WO2004060890A8 (en) 2005-08-18
EP1575947A1 (en) 2005-09-21
US20040147561A1 (en) 2004-07-29
CA2509213A1 (en) 2004-07-22
WO2004060890A1 (en) 2004-07-22
JP2006514059A (ja) 2006-04-27

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Legal Events

Date Code Title Description
DISC Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)