PL374536A1 - Związki heterocykliczne podstawione pirydylem do stosowania w leczeniu lub zapobieganiu infekcji HCV - Google Patents
Związki heterocykliczne podstawione pirydylem do stosowania w leczeniu lub zapobieganiu infekcji HCVInfo
- Publication number
- PL374536A1 PL374536A1 PL03374536A PL37453603A PL374536A1 PL 374536 A1 PL374536 A1 PL 374536A1 PL 03374536 A PL03374536 A PL 03374536A PL 37453603 A PL37453603 A PL 37453603A PL 374536 A1 PL374536 A1 PL 374536A1
- Authority
- PL
- Poland
- Prior art keywords
- treating
- hcv infection
- pyridyl substituted
- substituted heterocycles
- preventing hcv
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 125000004076 pyridyl group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40546702P | 2002-08-23 | 2002-08-23 | |
| US41783702P | 2002-10-11 | 2002-10-11 | |
| US47137303P | 2003-05-15 | 2003-05-15 | |
| US10/646,348 US7157473B2 (en) | 2002-08-23 | 2003-08-22 | Pyridyl substituted heterocycles useful for treating or preventing HCV infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL374536A1 true PL374536A1 (pl) | 2005-10-31 |
Family
ID=31950772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL03374536A PL374536A1 (pl) | 2002-08-23 | 2003-08-22 | Związki heterocykliczne podstawione pirydylem do stosowania w leczeniu lub zapobieganiu infekcji HCV |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7157473B2 (pl) |
| EP (1) | EP1530569A2 (pl) |
| JP (1) | JP2006501312A (pl) |
| KR (1) | KR20050033653A (pl) |
| AU (1) | AU2003262831A1 (pl) |
| BR (1) | BR0313755A (pl) |
| CA (1) | CA2494164A1 (pl) |
| HR (1) | HRP20050168A2 (pl) |
| IL (1) | IL166639A0 (pl) |
| MX (1) | MXPA05002082A (pl) |
| NO (1) | NO20051404L (pl) |
| NZ (1) | NZ537980A (pl) |
| PL (1) | PL374536A1 (pl) |
| RS (1) | RS20050175A (pl) |
| WO (1) | WO2004018463A2 (pl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| BR0313755A (pt) * | 2002-08-23 | 2005-06-21 | Rigel Pharmaceuticals Inc | Composto, métodos para inibir a replicação ou proliferação de um vìrion da hepatite c e para tratar ou prevenir uma infecção por hcv, e, composição |
| WO2004099164A1 (en) * | 2003-05-02 | 2004-11-18 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating hcv infection |
| WO2004099165A2 (en) * | 2003-05-02 | 2004-11-18 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds and hydro isomers thereof |
| US7220745B2 (en) | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
| WO2005009418A2 (en) | 2003-07-25 | 2005-02-03 | Idenix (Cayman) Limited | Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c |
| WO2005049065A2 (en) * | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections |
| ATE396718T1 (de) * | 2003-12-19 | 2008-06-15 | Rigel Pharmaceuticals Inc | Zusammensetzungen und verfahren zur behandlung von hepatitis-c-virus (hcv) infektion |
| US7514434B2 (en) | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
| JP2007530582A (ja) * | 2004-03-26 | 2007-11-01 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 代謝可能部分を含む複素環抗ウイルス化合物およびその使用 |
| CA2606106A1 (en) * | 2005-05-02 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
| CA3060814C (en) * | 2005-08-10 | 2022-04-19 | C.R. Bard, Inc. | Single-insertion, multiple sample biopsy device with integrated markers |
| KR100890862B1 (ko) * | 2005-11-07 | 2009-03-27 | 주식회사 엘지화학 | 유기 발광 소자 및 이의 제조 방법 |
| CN103622962A (zh) * | 2008-03-14 | 2014-03-12 | 大塚制药株式会社 | 制剂组合物在制备治疗以mmp-2及/或mmp-9为起因的纤维症的药物中的应用 |
| US8362020B2 (en) * | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| KR102655928B1 (ko) | 2015-06-23 | 2024-04-09 | 깃세이 야쿠힌 고교 가부시키가이샤 | 피라졸 유도체, 또는 그 약리학적으로 허용되는 염 |
| CN116535399B (zh) * | 2022-01-25 | 2024-02-27 | 中国药科大学 | 3-羟基-5-(异噁唑-5-基)吡啶甲酰甘氨酸类化合物、制法、药物组合物和应用 |
| WO2025037036A1 (en) * | 2023-08-17 | 2025-02-20 | Sanofi | Pyridyl imidazoles, their preparation and their therapeutic application |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2852503A (en) | 1953-12-31 | 1958-09-16 | American Cyanamid Co | 2, 5-bis (p-aminophenyl) furan azo derivatives |
| NL126440C (pl) | 1958-08-20 | |||
| US3335149A (en) | 1963-08-21 | 1967-08-08 | Monsanto Co | Thiazole diamines |
| FR1459375A (fr) | 1965-10-20 | 1966-04-29 | Westinghouse Electric Corp | Copolymères linéaires oxadiazole-imide |
| SU508198A3 (ru) | 1971-07-22 | 1976-03-25 | Группо Лепетит С.П.А. (Фирма) | Способ получени производных 1,2,4-триазола |
| DE2137719A1 (de) | 1971-07-28 | 1973-02-08 | Basf Ag | Verfahren zur herstellung von aminobenzonitrilen |
| US3964896A (en) | 1971-08-09 | 1976-06-22 | Uniroyal, Inc. | Oxadiazole benzoic acid derivatives as herbicides |
| US3853893A (en) | 1973-04-02 | 1974-12-10 | Squibb & Sons Inc | Anthelmintic 5-(pyridyl)-3-(isothiocyanophenyl) oxadiazoles |
| DE2721955A1 (de) | 1977-05-14 | 1978-11-23 | Basf Ag | Azofarbstoffe |
| DE3623302A1 (de) | 1985-11-09 | 1987-05-14 | Bayer Ag | Nicotinsaeurederivate |
| DE4016049A1 (de) | 1990-05-18 | 1991-11-21 | Basf Ag | 3-isoxazolylbenzylester, ihre herstellung und ihre verwendung |
| JPH04124178A (ja) | 1990-09-12 | 1992-04-24 | Sds Biotech Kk | 複素環式化合物および該化合物を含有する除草剤 |
| DE4124942A1 (de) | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4137940A1 (de) | 1991-11-18 | 1993-05-19 | Basf Ag | 3-isoxazolylphenylverbindungen, ihre herstellung und ihre verwendung |
| EP0634927B1 (en) | 1992-03-06 | 2001-07-04 | Lica Pharmaceuticals A/S | Treatment and prophylaxis of diseases caused by parasites, or bacteria |
| DE4210502A1 (de) | 1992-03-31 | 1993-10-07 | Bayer Ag | Verwendung von 3-aminosubstituierten Isoxazolderivaten zur Bekämpfung von Endoparasiten, neue 3-aminosubstituierte Isoxazolderivate und Verfahren zu ihrer Herstellung |
| WO1994017059A1 (fr) | 1993-01-29 | 1994-08-04 | Nippon Soda Co., Ltd. | Derive heterocyclique |
| DE4408084A1 (de) | 1994-03-10 | 1995-09-14 | Hoechst Ag | 3,5-Disubstituierte und 3,4,5-trisubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP0776894A4 (en) | 1994-08-02 | 1997-11-05 | Nippon Soda Co | OXAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE |
| NZ301265A (en) * | 1995-02-02 | 1998-12-23 | Smithkline Beecham Plc | Indole derivatives as 5ht receptor antagonists, preparation and pharmaceutical compositions thereof |
| DE19643037A1 (de) | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| UA68348C2 (en) | 1997-04-18 | 2004-08-16 | Searle & Co | Use of cyclooxygenase-2 inhibitors in preventing cardiovascular disorders |
| US20020035156A1 (en) | 1997-04-18 | 2002-03-21 | Barbara Roniker | Combination therapy in the prevention of cardiovascular disorders |
| KR20000068568A (ko) | 1997-07-17 | 2000-11-25 | 이데이 노부유끼 | 자기기록매체 및 이것을 이용한 자기기록 재생장치 |
| CA2307613A1 (en) | 1997-10-22 | 1999-04-29 | Eisai Co., Ltd. | Retinoic acid agonist as a prophylactic and therapeutic agent for nephritis |
| DE19860802A1 (de) | 1998-12-30 | 2000-10-26 | Virgene Pharmaceuticals Ag | Herstellung eines Mittels gegen Hepatitis B-, HI-, Paramyxo und Orthomyxo-Viren |
| DE19904389A1 (de) | 1999-02-04 | 2000-08-10 | Bayer Ag | Verwendung von substituierten Isoxazolcarbonsäuren und Derivate und neue Stoffe |
| MXPA01010675A (es) * | 1999-04-23 | 2002-06-04 | Takeda Chemical Industries Ltd | Compuestos de 5-piridil-1, 3-azol, proceso para su produccion y uso de los mismos. |
| GB2351081A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
| DE10032874A1 (de) | 2000-07-06 | 2002-01-17 | Bayer Ag | Arzneimittelkombinationen gegen virale Erkrankungen |
| CA2404384A1 (en) * | 2000-03-30 | 2001-10-11 | Takeda Chemical Industries, Ltd. | Substituted 1,3-thiazole compounds, their production and use |
| WO2001078648A2 (en) * | 2000-04-17 | 2001-10-25 | Dong Wha Pharm. Ind. Co., Ltd. | 6-methylnicotinamide derivatives as antiviral agents |
| US6579880B2 (en) | 2000-06-06 | 2003-06-17 | Ortho-Mcneil Pharmaceutical, Inc. | Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8 |
| GB0017676D0 (en) * | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
| WO2002020436A2 (en) | 2000-09-05 | 2002-03-14 | Neogenesis Pharmaceuticals, Inc. | Methods for forming combinatorial libraries combining amide bond formation with epoxide opening |
| WO2002046186A1 (en) * | 2000-12-08 | 2002-06-13 | Takeda Chemical Industries, Ltd. | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
| ES2295316T3 (es) | 2001-01-13 | 2008-04-16 | University Of North Carolina At Chapel Hill | Compuestos, metodos y composiciones utiles para el tratamiento de la infeccion por virus de la diarrea virica bovina (bvdv) e infeccion por virus de la hepatitis c (hcv). |
| ES2252455T3 (es) * | 2001-04-19 | 2006-05-16 | Bayer Healthcare Ag | Arilsulfonamidas como agentes antivirales. |
| DE10148598A1 (de) * | 2001-04-19 | 2002-10-24 | Bayer Ag | Neue Arylsulfonamide als antivirale Mittel |
| AU2002341921B2 (en) * | 2001-10-04 | 2007-05-31 | Merck Sharp & Dohme Corp. | Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5 |
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| BR0313755A (pt) | 2002-08-23 | 2005-06-21 | Rigel Pharmaceuticals Inc | Composto, métodos para inibir a replicação ou proliferação de um vìrion da hepatite c e para tratar ou prevenir uma infecção por hcv, e, composição |
| US7220745B2 (en) | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
-
2003
- 2003-08-22 BR BR0313755-4A patent/BR0313755A/pt not_active IP Right Cessation
- 2003-08-22 RS YUP-2005/0175A patent/RS20050175A/sr unknown
- 2003-08-22 US US10/646,348 patent/US7157473B2/en not_active Expired - Lifetime
- 2003-08-22 WO PCT/US2003/026478 patent/WO2004018463A2/en not_active Ceased
- 2003-08-22 MX MXPA05002082A patent/MXPA05002082A/es unknown
- 2003-08-22 CA CA002494164A patent/CA2494164A1/en not_active Abandoned
- 2003-08-22 EP EP03793349A patent/EP1530569A2/en not_active Withdrawn
- 2003-08-22 AU AU2003262831A patent/AU2003262831A1/en not_active Abandoned
- 2003-08-22 JP JP2005501778A patent/JP2006501312A/ja active Pending
- 2003-08-22 NZ NZ537980A patent/NZ537980A/en not_active IP Right Cessation
- 2003-08-22 HR HR20050168A patent/HRP20050168A2/hr not_active Application Discontinuation
- 2003-08-22 PL PL03374536A patent/PL374536A1/pl not_active Application Discontinuation
- 2003-08-22 KR KR1020057003019A patent/KR20050033653A/ko not_active Ceased
-
2005
- 2005-02-01 IL IL16663905A patent/IL166639A0/xx unknown
- 2005-03-17 NO NO20051404A patent/NO20051404L/no not_active Application Discontinuation
-
2006
- 2006-11-21 US US11/561,991 patent/US7332602B2/en not_active Expired - Lifetime
-
2007
- 2007-12-20 US US11/960,990 patent/US7714137B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004018463A3 (en) | 2004-05-06 |
| US7332602B2 (en) | 2008-02-19 |
| US20040127497A1 (en) | 2004-07-01 |
| KR20050033653A (ko) | 2005-04-12 |
| JP2006501312A (ja) | 2006-01-12 |
| IL166639A0 (en) | 2006-01-15 |
| US20080171871A1 (en) | 2008-07-17 |
| NO20051404L (no) | 2005-05-10 |
| US7714137B2 (en) | 2010-05-11 |
| BR0313755A (pt) | 2005-06-21 |
| US7157473B2 (en) | 2007-01-02 |
| AU2003262831A1 (en) | 2004-03-11 |
| NZ537980A (en) | 2007-08-31 |
| HRP20050168A2 (en) | 2005-10-31 |
| RS20050175A (sr) | 2007-09-21 |
| EP1530569A2 (en) | 2005-05-18 |
| MXPA05002082A (es) | 2005-06-08 |
| WO2004018463A2 (en) | 2004-03-04 |
| US20070155966A1 (en) | 2007-07-05 |
| CA2494164A1 (en) | 2004-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |