PL373622A1 - Spirocykliczne piperydyny jako antagoniści MCH1 iich zastosowania - Google Patents

Spirocykliczne piperydyny jako antagoniści MCH1 iich zastosowania

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Publication number
PL373622A1
PL373622A1 PL03373622A PL37362203A PL373622A1 PL 373622 A1 PL373622 A1 PL 373622A1 PL 03373622 A PL03373622 A PL 03373622A PL 37362203 A PL37362203 A PL 37362203A PL 373622 A1 PL373622 A1 PL 373622A1
Authority
PL
Poland
Prior art keywords
subject
compound
provides
pharmaceutically acceptable
pharmaceutical composition
Prior art date
Application number
PL03373622A
Other languages
English (en)
Inventor
Mohammad Marzabadi
Allen Jiang
Kai Lu
Chien-An Chen
John Deleon
John Wetzel
Original Assignee
H.Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S filed Critical H.Lundbeck A/S
Publication of PL373622A1 publication Critical patent/PL373622A1/pl

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
PL03373622A 2002-07-03 2003-07-03 Spirocykliczne piperydyny jako antagoniści MCH1 iich zastosowania PL373622A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18914602A 2002-07-03 2002-07-03

Publications (1)

Publication Number Publication Date
PL373622A1 true PL373622A1 (pl) 2005-09-05

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Application Number Title Priority Date Filing Date
PL03373622A PL373622A1 (pl) 2002-07-03 2003-07-03 Spirocykliczne piperydyny jako antagoniści MCH1 iich zastosowania

Country Status (21)

Country Link
US (1) US7335665B2 (pl)
EP (1) EP1531816B1 (pl)
JP (1) JP2006501188A (pl)
KR (1) KR20050047075A (pl)
CN (1) CN1668300A (pl)
AT (1) ATE421504T1 (pl)
AU (1) AU2003261133A1 (pl)
BR (1) BR0312256A (pl)
CA (1) CA2485375A1 (pl)
DE (1) DE60325973D1 (pl)
EA (1) EA007387B1 (pl)
ES (1) ES2318165T3 (pl)
IL (1) IL165906A0 (pl)
IS (1) IS7559A (pl)
MX (1) MXPA04012171A (pl)
NO (1) NO20050145L (pl)
NZ (1) NZ536844A (pl)
PL (1) PL373622A1 (pl)
UA (1) UA77814C2 (pl)
WO (1) WO2004004714A1 (pl)
ZA (1) ZA200409426B (pl)

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JP2009507800A (ja) 2005-09-09 2009-02-26 ユーロ−セルティーク エス．エイ． 縮合およびスピロ環化合物ならびにその使用
RU2008130094A (ru) * 2005-12-22 2010-01-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецепторов
EP1991528A2 (en) * 2006-01-18 2008-11-19 Siena Biotech S.p.A. Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof
WO2007100670A1 (en) * 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Spiro condensed piperidnes as modulators of muscarinic receptors
CN101426499A (zh) * 2006-02-22 2009-05-06 弗特克斯药品有限公司 毒蕈碱受体调节剂
EP2040706A2 (en) * 2006-06-29 2009-04-01 Vertex Pharmceuticals Incorporated Modulators of muscarinic receptors
JP2010500412A (ja) * 2006-08-15 2010-01-07 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
CN101573121A (zh) 2006-08-18 2009-11-04 弗特克斯药品有限公司 毒蕈碱受体调节剂
EP2072519A4 (en) * 2006-09-28 2009-10-21 Banyu Pharma Co Ltd DIARYLKETIMINDERIVAT
CL2008000119A1 (es) 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
KR100816267B1 (ko) * 2007-07-18 2008-03-25 주식회사 코리아나화장품 천상초 추출물을 유효성분으로 함유하는 화장료 조성물
WO2009045519A1 (en) * 2007-10-03 2009-04-09 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
JP5746612B2 (ja) * 2008-03-19 2015-07-08 オーリムメッド・ファルマ・インコーポレーテッド 中枢神経系疾患および障害の治療に有効な新規化合物
US10793515B2 (en) 2008-03-19 2020-10-06 Aurimmed Pharma, Inc. Compounds advantageous in the treatment of central nervous system diseases and disorders
EP2563764B1 (en) * 2010-04-26 2015-02-25 Merck Sharp & Dohme Corp. Novel spiropiperidine prolylcarboxypeptidase inhibitors

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JP2004504303A (ja) * 2000-07-05 2004-02-12 シナプティック・ファーマスーティカル・コーポレーション 選択的メラニン凝集ホルモン−１（ｍｃｈ１）受容体アンタゴニストおよびその使用
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WO2002088089A1 (fr) * 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Derives de spiropiperidine, antagonistes du recepteur de nociceptine les contenant en tant qu'ingredient actif et compositions medicinales
KR20040027870A (ko) 2001-07-05 2004-04-01 시냅틱 파마세틱칼 코포레이션 Ｍｃｈ 선택적인 안타고니스트로서의 치환 아닐린 피페리딘
CA2515717A1 (en) 2003-02-10 2004-08-19 Banyu Pharmaceutical Co., Ltd. Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient

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WO2004004714A1 (en) 2004-01-15
BR0312256A (pt) 2005-04-26
KR20050047075A (ko) 2005-05-19
EA200500156A1 (ru) 2005-06-30
JP2006501188A (ja) 2006-01-12
ES2318165T3 (es) 2009-05-01
EP1531816B1 (en) 2009-01-21
IL165906A0 (en) 2006-01-15
UA77814C2 (en) 2007-01-15
DE60325973D1 (de) 2009-03-12
ZA200409426B (en) 2006-04-26
NZ536844A (en) 2007-02-23
MXPA04012171A (es) 2005-02-25
EP1531816A4 (en) 2005-12-28
AU2003261133A1 (en) 2004-01-23
CA2485375A1 (en) 2004-07-15
EP1531816A1 (en) 2005-05-25
ATE421504T1 (de) 2009-02-15
US20060173027A1 (en) 2006-08-03
NO20050145L (no) 2005-01-11
EA007387B1 (ru) 2006-10-27
US7335665B2 (en) 2008-02-26

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