DE60325973D1 - Spirozyklische piperidine als mch1-antagonisten und ihre verwendungen - Google Patents
Spirozyklische piperidine als mch1-antagonisten und ihre verwendungenInfo
- Publication number
- DE60325973D1 DE60325973D1 DE60325973T DE60325973T DE60325973D1 DE 60325973 D1 DE60325973 D1 DE 60325973D1 DE 60325973 T DE60325973 T DE 60325973T DE 60325973 T DE60325973 T DE 60325973T DE 60325973 D1 DE60325973 D1 DE 60325973D1
- Authority
- DE
- Germany
- Prior art keywords
- subject
- compound
- provides
- pharmaceutically acceptable
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Toxicology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18914602A | 2002-07-03 | 2002-07-03 | |
PCT/US2003/021348 WO2004004714A1 (en) | 2002-07-03 | 2003-07-03 | Spirocyclic piperidines as mch1 antagonists and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60325973D1 true DE60325973D1 (de) | 2009-03-12 |
Family
ID=30114021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60325973T Expired - Fee Related DE60325973D1 (de) | 2002-07-03 | 2003-07-03 | Spirozyklische piperidine als mch1-antagonisten und ihre verwendungen |
Country Status (21)
Country | Link |
---|---|
US (1) | US7335665B2 (de) |
EP (1) | EP1531816B1 (de) |
JP (1) | JP2006501188A (de) |
KR (1) | KR20050047075A (de) |
CN (1) | CN1668300A (de) |
AT (1) | ATE421504T1 (de) |
AU (1) | AU2003261133A1 (de) |
BR (1) | BR0312256A (de) |
CA (1) | CA2485375A1 (de) |
DE (1) | DE60325973D1 (de) |
EA (1) | EA007387B1 (de) |
ES (1) | ES2318165T3 (de) |
IL (1) | IL165906A0 (de) |
IS (1) | IS7559A (de) |
MX (1) | MXPA04012171A (de) |
NO (1) | NO20050145L (de) |
NZ (1) | NZ536844A (de) |
PL (1) | PL373622A1 (de) |
UA (1) | UA77814C2 (de) |
WO (1) | WO2004004714A1 (de) |
ZA (1) | ZA200409426B (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
US7105544B2 (en) | 2001-07-05 | 2006-09-12 | Synaptic Pharmaceutical Corporation | Substituted alkyl amido piperidines |
US7199135B2 (en) | 2001-07-05 | 2007-04-03 | H. Lundbeck A/S | Substituted alkyl amido piperidines |
JP2006511500A (ja) * | 2002-10-30 | 2006-04-06 | メルク エンド カムパニー インコーポレーテッド | γ−アミノアミド系のケモカイン受容体活性調節剤 |
AU2004209505B2 (en) * | 2003-02-10 | 2009-07-23 | Banyu Pharmaceutical Co., Ltd. | Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient |
US7786141B2 (en) | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
WO2006023852A2 (en) | 2004-08-19 | 2006-03-02 | Vertex Pharmaceuticals, Incorporated | Modulators of muscarinic receptors |
US7863449B2 (en) | 2004-11-29 | 2011-01-04 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
WO2007028638A1 (en) | 2005-09-09 | 2007-03-15 | Euro-Celtique S.A. | Fused and spirocycle compounds and the use thereof |
AU2006330866A1 (en) * | 2005-12-22 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
EP1991528A2 (de) * | 2006-01-18 | 2008-11-19 | Siena Biotech S.p.A. | Modulatoren von alpha7-nicotinischen acetylcholinrezeptoren und therapeutische verwendungen davon |
JP2009527568A (ja) * | 2006-02-22 | 2009-07-30 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
KR20080098070A (ko) * | 2006-02-22 | 2008-11-06 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린성 수용체의 조절제로서의 스피로 축합된 피페리딘 |
JP2009542670A (ja) * | 2006-06-29 | 2009-12-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
WO2008021375A2 (en) * | 2006-08-15 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
JP2010501561A (ja) | 2006-08-18 | 2010-01-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
AU2007301126A1 (en) * | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
KR100816267B1 (ko) * | 2007-07-18 | 2008-03-25 | 주식회사 코리아나화장품 | 천상초 추출물을 유효성분으로 함유하는 화장료 조성물 |
MX2010003373A (es) * | 2007-10-03 | 2010-04-30 | Vertex Pharma | Moduladores de receptores muscarinicos. |
KR101672884B1 (ko) * | 2008-03-19 | 2016-11-04 | 오림드 파마, 인코포레이티드 | 중추신경계 질환 및 질병 치료에 유효한 신규 화합물 |
US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
WO2011137024A1 (en) * | 2010-04-26 | 2011-11-03 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
US5382583A (en) * | 1989-04-22 | 1995-01-17 | John Wyeth & Brother, Limited | Piperazine derivatives |
WO1997045415A1 (en) * | 1996-05-28 | 1997-12-04 | Rotta Research Laboratorium S.P.A. | Polyamide derivatives or ornithine, lysine and analogous substances with cck-b and gastrin-antagonistic activity |
AU5604998A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
AU783403B2 (en) * | 2000-07-05 | 2005-10-20 | H. Lundbeck A/S | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof |
JP2004502423A (ja) | 2000-07-05 | 2004-01-29 | シナプティック・ファーマスーティカル・コーポレーション | ヒトメラニン濃縮ホルモン受容体(mch1)をコードするdna及びその使用 |
WO2002088089A1 (fr) | 2001-04-19 | 2002-11-07 | Banyu Pharmaceutical Co., Ltd. | Derives de spiropiperidine, antagonistes du recepteur de nociceptine les contenant en tant qu'ingredient actif et compositions medicinales |
MXPA03011886A (es) | 2001-07-05 | 2005-03-07 | Lundbeck & Co As H | Piperidinias anilinicas sustituidas como antagonistas selectivos de mch. |
AU2004209505B2 (en) | 2003-02-10 | 2009-07-23 | Banyu Pharmaceutical Co., Ltd. | Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient |
-
2003
- 2003-03-07 UA UA20041210497A patent/UA77814C2/uk unknown
- 2003-07-03 ES ES03763351T patent/ES2318165T3/es not_active Expired - Lifetime
- 2003-07-03 CN CNA038158833A patent/CN1668300A/zh active Pending
- 2003-07-03 EA EA200500156A patent/EA007387B1/ru not_active IP Right Cessation
- 2003-07-03 MX MXPA04012171A patent/MXPA04012171A/es not_active Application Discontinuation
- 2003-07-03 BR BR0312256-5A patent/BR0312256A/pt not_active IP Right Cessation
- 2003-07-03 US US10/518,939 patent/US7335665B2/en not_active Expired - Fee Related
- 2003-07-03 AU AU2003261133A patent/AU2003261133A1/en not_active Abandoned
- 2003-07-03 KR KR1020057000069A patent/KR20050047075A/ko not_active Application Discontinuation
- 2003-07-03 PL PL03373622A patent/PL373622A1/xx not_active Application Discontinuation
- 2003-07-03 DE DE60325973T patent/DE60325973D1/de not_active Expired - Fee Related
- 2003-07-03 AT AT03763351T patent/ATE421504T1/de not_active IP Right Cessation
- 2003-07-03 JP JP2004520024A patent/JP2006501188A/ja not_active Withdrawn
- 2003-07-03 CA CA002485375A patent/CA2485375A1/en not_active Abandoned
- 2003-07-03 NZ NZ536844A patent/NZ536844A/en unknown
- 2003-07-03 EP EP03763351A patent/EP1531816B1/de not_active Expired - Lifetime
- 2003-07-03 WO PCT/US2003/021348 patent/WO2004004714A1/en active Application Filing
-
2004
- 2004-11-23 ZA ZA200409426A patent/ZA200409426B/en unknown
- 2004-11-26 IS IS7559A patent/IS7559A/is unknown
- 2004-12-21 IL IL16590604A patent/IL165906A0/xx unknown
-
2005
- 2005-01-11 NO NO20050145A patent/NO20050145L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ536844A (en) | 2007-02-23 |
EP1531816B1 (de) | 2009-01-21 |
WO2004004714A1 (en) | 2004-01-15 |
BR0312256A (pt) | 2005-04-26 |
EA200500156A1 (ru) | 2005-06-30 |
IL165906A0 (en) | 2006-01-15 |
KR20050047075A (ko) | 2005-05-19 |
EA007387B1 (ru) | 2006-10-27 |
ZA200409426B (en) | 2006-04-26 |
AU2003261133A1 (en) | 2004-01-23 |
PL373622A1 (en) | 2005-09-05 |
CN1668300A (zh) | 2005-09-14 |
ES2318165T3 (es) | 2009-05-01 |
EP1531816A4 (de) | 2005-12-28 |
IS7559A (is) | 2004-11-26 |
JP2006501188A (ja) | 2006-01-12 |
UA77814C2 (en) | 2007-01-15 |
NO20050145L (no) | 2005-01-11 |
US7335665B2 (en) | 2008-02-26 |
ATE421504T1 (de) | 2009-02-15 |
CA2485375A1 (en) | 2004-07-15 |
EP1531816A1 (de) | 2005-05-25 |
US20060173027A1 (en) | 2006-08-03 |
MXPA04012171A (es) | 2005-02-25 |
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