PL370632A1 - Partial dopamine-d2 receptor agonist plus serotonin and/oder noradrenaline inhibitor activity - Google Patents
Partial dopamine-d2 receptor agonist plus serotonin and/oder noradrenaline inhibitor activityInfo
- Publication number
- PL370632A1 PL370632A1 PL03370632A PL37063203A PL370632A1 PL 370632 A1 PL370632 A1 PL 370632A1 PL 03370632 A PL03370632 A PL 03370632A PL 37063203 A PL37063203 A PL 37063203A PL 370632 A1 PL370632 A1 PL 370632A1
- Authority
- PL
- Poland
- Prior art keywords
- noradrenaline
- oder
- receptor agonist
- inhibitor activity
- agonist plus
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 title 1
- 229940096895 Dopamine D2 receptor agonist Drugs 0.000 title 1
- 239000002288 dopamine 2 receptor stimulating agent Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229960002748 norepinephrine Drugs 0.000 title 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 title 1
- 229940076279 serotonin Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020076344 EP1336406A1 (en) | 2002-02-14 | 2002-02-14 | Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL370632A1 true PL370632A1 (en) | 2005-05-30 |
Family
ID=27619173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL03370632A PL370632A1 (en) | 2002-02-14 | 2003-02-11 | Partial dopamine-d2 receptor agonist plus serotonin and/oder noradrenaline inhibitor activity |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050038015A1 (https=) |
| EP (2) | EP1336406A1 (https=) |
| JP (1) | JP2005517036A (https=) |
| KR (1) | KR20040081779A (https=) |
| CN (1) | CN1592614A (https=) |
| AU (1) | AU2003208714A1 (https=) |
| BR (1) | BR0306147A (https=) |
| CA (1) | CA2462688A1 (https=) |
| HR (1) | HRP20040276A2 (https=) |
| IL (1) | IL160942A0 (https=) |
| MX (1) | MXPA04004745A (https=) |
| NO (1) | NO20043833L (https=) |
| PL (1) | PL370632A1 (https=) |
| RU (1) | RU2004112546A (https=) |
| WO (1) | WO2003068207A2 (https=) |
| ZA (1) | ZA200404740B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001014330A2 (en) | 1999-08-23 | 2001-03-01 | Solvay Pharmaceuticals B.V. | Phenylpiperazines as serotonin reuptake inhibitors |
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| AR032711A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene |
| AR032712A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| ES2323451T7 (es) | 2001-07-20 | 2011-08-01 | Psychogenics Inc. | Tratamiento para el trastorno de hiperactividad con deficit de atencion. |
| KR100842694B1 (ko) | 2002-12-27 | 2008-07-01 | 오쓰까 세이야꾸 가부시키가이샤 | 기분 장애 치료용 카르보스티릴 유도체 및 세로토닌 재흡수억제제 |
| AR042806A1 (es) * | 2002-12-27 | 2005-07-06 | Otsuka Pharma Co Ltd | Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo |
| DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
| DE10334187A1 (de) * | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
| GB0327195D0 (en) * | 2003-11-21 | 2003-12-24 | Smithkline Beecham Corp | Novel use |
| EP1595542A1 (en) * | 2004-03-26 | 2005-11-16 | Solvay Pharmaceuticals B.V. | Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds |
| US7596407B2 (en) | 2004-03-26 | 2009-09-29 | Solvay Pharmaceuticals, B.V. | Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds |
| WO2007019880A1 (en) * | 2005-08-18 | 2007-02-22 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Use of a selective inhibitor of norepinephrine reuptake for treating respiratory disorders resulting from rett syndrome |
| WO2007065713A2 (en) * | 2005-12-08 | 2007-06-14 | Axxonis Pharma Gmbh | Use of 8-alpha-ergolines for the treatment of traumatic brain disorders |
| JP2010518023A (ja) * | 2007-02-01 | 2010-05-27 | アラン アイ． グリーン | ドーパミンＤ２受容体遮断剤とノルエピネフリン再取り込み阻害剤およびノルエピネフリンα２受容体遮断剤との組み合わせ |
| SG183069A1 (en) * | 2007-07-23 | 2012-08-30 | Synosia Therapeutics | Treatment of post-traumatic stress disorder |
| TW200936130A (en) * | 2008-02-26 | 2009-09-01 | Lundbeck & Co As H | Uses of indane compounds |
| WO2011082266A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted heterocyclic compounds |
| CA2796722C (en) * | 2010-04-19 | 2021-06-01 | Nlife Therapeutics, S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types |
| CN111134894B (zh) * | 2020-01-17 | 2022-02-22 | 上海长海医院 | 一种在体测定犬前列腺组织连续动态游离药物浓度的采样方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA71590C2 (en) * | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| WO2001014330A2 (en) * | 1999-08-23 | 2001-03-01 | Solvay Pharmaceuticals B.V. | Phenylpiperazines as serotonin reuptake inhibitors |
-
2002
- 2002-02-14 EP EP20020076344 patent/EP1336406A1/en not_active Withdrawn
-
2003
- 2003-02-11 CA CA002462688A patent/CA2462688A1/en not_active Abandoned
- 2003-02-11 PL PL03370632A patent/PL370632A1/xx not_active Application Discontinuation
- 2003-02-11 BR BR0306147-7A patent/BR0306147A/pt not_active IP Right Cessation
- 2003-02-11 CN CNA038015544A patent/CN1592614A/zh active Pending
- 2003-02-11 RU RU2004112546/15A patent/RU2004112546A/ru not_active Application Discontinuation
- 2003-02-11 WO PCT/EP2003/050015 patent/WO2003068207A2/en not_active Ceased
- 2003-02-11 MX MXPA04004745A patent/MXPA04004745A/es unknown
- 2003-02-11 AU AU2003208714A patent/AU2003208714A1/en not_active Abandoned
- 2003-02-11 US US10/490,365 patent/US20050038015A1/en not_active Abandoned
- 2003-02-11 JP JP2003567389A patent/JP2005517036A/ja not_active Withdrawn
- 2003-02-11 IL IL16094203A patent/IL160942A0/xx unknown
- 2003-02-11 EP EP03706621A patent/EP1476148A2/en not_active Withdrawn
- 2003-02-11 HR HR20040276A patent/HRP20040276A2/hr not_active Application Discontinuation
- 2003-02-11 KR KR10-2004-7012355A patent/KR20040081779A/ko not_active Ceased
-
2004
- 2004-06-15 ZA ZA200404740A patent/ZA200404740B/en unknown
- 2004-09-13 NO NO20043833A patent/NO20043833L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20043833L (no) | 2004-09-13 |
| MXPA04004745A (es) | 2004-08-02 |
| HRP20040276A2 (en) | 2005-04-30 |
| CN1592614A (zh) | 2005-03-09 |
| IL160942A0 (en) | 2004-08-31 |
| WO2003068207A2 (en) | 2003-08-21 |
| JP2005517036A (ja) | 2005-06-09 |
| BR0306147A (pt) | 2004-10-19 |
| CA2462688A1 (en) | 2003-08-21 |
| WO2003068207A3 (en) | 2003-12-18 |
| RU2004112546A (ru) | 2005-03-27 |
| ZA200404740B (en) | 2005-08-23 |
| EP1336406A1 (en) | 2003-08-20 |
| AU2003208714A1 (en) | 2003-09-04 |
| EP1476148A2 (en) | 2004-11-17 |
| US20050038015A1 (en) | 2005-02-17 |
| KR20040081779A (ko) | 2004-09-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL370632A1 (en) | Partial dopamine-d2 receptor agonist plus serotonin and/oder noradrenaline inhibitor activity | |
| PL374314A1 (en) | Benzothiazole derivatives having beta-2-adrenoreceptor agonist activity | |
| EP1507756A4 (en) | CCR9 INHIBITORS AND USE THEREOF | |
| AU2002367739A1 (en) | Activity management method | |
| PT1531794T (pt) | Epinefrina inalável | |
| DK1615889T3 (da) | Biphenylderivater med beta2-adrenergisk receptoragonist- og muscarinisk receptorantagonistaktivitet | |
| AU2003265853A8 (en) | Hedgehog antagonists, methods and uses related thereto | |
| AU2003282676A8 (en) | Free list and ring data structure management | |
| AU2003288640A1 (en) | Benzamide inhibitors of the p2x7 receptor | |
| PT1638933E (pt) | Derivados de n-pirrolidin-3-il-amida como inibidores de recaptação de serotonina e noradrenalina | |
| ATE394375T1 (de) | Zusammensetzung enthaltend einen tachykininrezeptor antagonisten und einen serotonin-wiederaufnahmehemmer | |
| AU2003222045A8 (en) | Serotonin and catecholamine system segment optimization techonology | |
| GB0226727D0 (en) | Intrabodies | |
| ZA200408315B (en) | Peptide deformylase inhibitors | |
| PL374581A1 (en) | Diaminothiazoles and use thereof as cdk4 inhibitors | |
| EP1540415A4 (en) | CHAUMARD SET AND COINCEUR TAQUET | |
| AU2003233958A1 (en) | Heterocyclic amides with alpha-4 integrin antagonist activity | |
| IL172965A0 (en) | The combination of a serotonin reuptake inhibitors and agomelatine | |
| GB2410989B (en) | Subsea structure and methods of construction and installation thereof | |
| AU2003296960A8 (en) | Peptide deformylase inhibitors | |
| MXPA03004212A (es) | Metodos y aparatos para determinar la elasticidad de arandelas de resorte. | |
| IL176238A0 (en) | The combination of a serotonin reuptake inhibitor and a histamine 3 receptor antagonist, inverse agonist or partial agonist | |
| GB2409696B (en) | Subsea structure and methods of installation thereof | |
| AU2003290363A8 (en) | Therapeutic use of selective noradrenaline reuptake inhibitors | |
| PL374656A1 (en) | Combinations of atorvastatin and alpha1, adrenergic receptor antagonists |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |