PL366459A1 - Nowe związki pirydylocyjanoguanidyny - Google Patents
Nowe związki pirydylocyjanoguanidynyInfo
- Publication number
- PL366459A1 PL366459A1 PL02366459A PL36645902A PL366459A1 PL 366459 A1 PL366459 A1 PL 366459A1 PL 02366459 A PL02366459 A PL 02366459A PL 36645902 A PL36645902 A PL 36645902A PL 366459 A1 PL366459 A1 PL 366459A1
- Authority
- PL
- Poland
- Prior art keywords
- halogen
- alkylcarbonyl
- aminoalkyl
- formyl
- alkoxycarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29292701P | 2001-05-24 | 2001-05-24 | |
US29292801P | 2001-05-24 | 2001-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL366459A1 true PL366459A1 (pl) | 2005-02-07 |
Family
ID=26967641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL02366459A PL366459A1 (pl) | 2001-05-24 | 2002-05-24 | Nowe związki pirydylocyjanoguanidyny |
Country Status (18)
Country | Link |
---|---|
US (2) | US7304066B2 (pl) |
EP (1) | EP1397355B1 (pl) |
JP (1) | JP4429607B2 (pl) |
KR (1) | KR20030097897A (pl) |
CN (1) | CN1247570C (pl) |
AT (1) | ATE442362T1 (pl) |
BR (1) | BR0209930A (pl) |
CA (1) | CA2447021C (pl) |
CZ (1) | CZ20033190A3 (pl) |
DE (1) | DE60233656D1 (pl) |
ES (1) | ES2328799T3 (pl) |
HK (1) | HK1066216A1 (pl) |
HU (1) | HUP0400021A3 (pl) |
IL (1) | IL158574A0 (pl) |
MX (1) | MXPA03010669A (pl) |
PL (1) | PL366459A1 (pl) |
RU (1) | RU2292344C2 (pl) |
WO (1) | WO2002094813A1 (pl) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004041285A1 (en) | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
CN1918131B (zh) * | 2004-02-05 | 2011-05-04 | 前体生物药物股份公司 | 谷氨酰胺酰基环化酶抑制剂 |
PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
TW200626142A (en) | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
JP5189367B2 (ja) * | 2004-12-22 | 2013-04-24 | レオ ファーマ アクティーゼルスカブ | 新規シアノグアニジン化合物 |
WO2007005534A2 (en) | 2005-06-30 | 2007-01-11 | Smithkline Beecham Corporation | Chemical compounds |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
RU2011111728A (ru) | 2008-08-29 | 2012-10-10 | Топотаргет А/С (Dk) | Новые производные мочевины и тиомочевины |
CA2751495C (en) * | 2009-02-06 | 2013-08-20 | Tianjin Hemay Bio-Tech Co., Ltd. | Pharmaceutical compositions comprising a pyridyl cyanoguanidine and cyclodextrin and/or derivatives thereof |
JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ikk2阻害剤としてのインドール誘導体 |
WO2011006988A1 (en) | 2009-07-17 | 2011-01-20 | Topotarget A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
US8604065B2 (en) | 2010-02-04 | 2013-12-10 | Hesheng Zhang | Pyridyl cyanoguanidine derivatives |
WO2011095027A1 (zh) * | 2010-02-04 | 2011-08-11 | 天津和美生物技术有限公司 | 吡啶基氰基胍衍生物 |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
WO2011121055A1 (en) | 2010-03-31 | 2011-10-06 | Topotarget A/S | Pyridinyl derivatives comprising a cyanoguanidine or squaric acid moiety |
EP2611778B1 (en) * | 2010-09-03 | 2015-08-05 | Forma TM, LLC. | Guanidine compounds and compositions for the inhibition of nampt |
JP2013540781A (ja) | 2010-10-26 | 2013-11-07 | ティエンジン ホーメイ バイオ−テック カンパニー, リミテッド | N−(6−(4−クロロフェノキシ)ヘキシル)−n’−シアノ−n’’−(4−ピリジル)グアニジンの結晶多形とその製造及び使用 |
PT2649048T (pt) * | 2010-12-09 | 2016-07-13 | Radikal Therapeutics Inc | Derivados de nitróxido multifuncionais e usos dos mesmos |
IL289300B2 (en) * | 2012-04-13 | 2024-05-01 | Epizyme Inc | Combined treatment for cancer |
KR101656663B1 (ko) | 2015-07-27 | 2016-09-13 | 충남대학교산학협력단 | 암 예방 및 치료용 조성물 |
PT3837256T (pt) | 2018-08-17 | 2023-05-23 | Novartis Ag | Compostos e composições de ureia como inibidores de smarca2/brm-atpase |
CN110734405A (zh) * | 2019-11-11 | 2020-01-31 | 华东数字医学工程研究院 | 一种n-(6-氨己基)-n’-甲基-2,2’-联咪唑的合成方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5696140A (en) * | 1992-09-15 | 1997-12-09 | Leo Pharmaceutical Products Ltd. | N-cyano-N'-pyridylguanidines as serotonin antagonists |
GB9219472D0 (en) * | 1992-09-15 | 1992-10-28 | Leo Pharm Prod Ltd | Chemical compounds |
GB9711123D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
GB9711122D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
GB9711119D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
GB9711124D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
US7129043B1 (en) * | 1998-10-22 | 2006-10-31 | Duke University | Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease |
WO2000061561A1 (en) | 1999-04-09 | 2000-10-19 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
AU4076500A (en) | 1999-04-09 | 2000-11-14 | Shionogi Bioresearch Corp. | (n)-substituted cyanoguanidine compounds |
ES2292462T3 (es) | 1999-08-03 | 2008-03-16 | Abbott Laboratories | Agentes abridores de los canales del potasio. |
US6645968B2 (en) | 1999-08-03 | 2003-11-11 | Abbott Laboratories | Potassium channel openers |
-
2002
- 2002-05-24 KR KR10-2003-7015244A patent/KR20030097897A/ko not_active Application Discontinuation
- 2002-05-24 AT AT02771630T patent/ATE442362T1/de not_active IP Right Cessation
- 2002-05-24 PL PL02366459A patent/PL366459A1/pl not_active Application Discontinuation
- 2002-05-24 US US10/476,856 patent/US7304066B2/en not_active Expired - Lifetime
- 2002-05-24 DE DE60233656T patent/DE60233656D1/de not_active Expired - Lifetime
- 2002-05-24 EP EP02771630A patent/EP1397355B1/en not_active Expired - Lifetime
- 2002-05-24 WO PCT/DK2002/000353 patent/WO2002094813A1/en active Application Filing
- 2002-05-24 JP JP2002591486A patent/JP4429607B2/ja not_active Expired - Fee Related
- 2002-05-24 CZ CZ20033190A patent/CZ20033190A3/cs unknown
- 2002-05-24 CN CNB028101022A patent/CN1247570C/zh not_active Expired - Lifetime
- 2002-05-24 HU HU0400021A patent/HUP0400021A3/hu unknown
- 2002-05-24 CA CA2447021A patent/CA2447021C/en not_active Expired - Lifetime
- 2002-05-24 BR BR0209930-6A patent/BR0209930A/pt not_active IP Right Cessation
- 2002-05-24 ES ES02771630T patent/ES2328799T3/es not_active Expired - Lifetime
- 2002-05-24 RU RU2003137007/04A patent/RU2292344C2/ru active
- 2002-05-24 MX MXPA03010669A patent/MXPA03010669A/es not_active Application Discontinuation
- 2002-05-24 IL IL15857402A patent/IL158574A0/xx unknown
-
2004
- 2004-11-18 HK HK04109102A patent/HK1066216A1/xx not_active IP Right Cessation
-
2007
- 2007-11-30 US US11/998,575 patent/US7807682B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2447021A1 (en) | 2002-11-28 |
CN1247570C (zh) | 2006-03-29 |
RU2003137007A (ru) | 2005-04-20 |
CA2447021C (en) | 2010-08-10 |
KR20030097897A (ko) | 2003-12-31 |
ES2328799T3 (es) | 2009-11-18 |
JP4429607B2 (ja) | 2010-03-10 |
US7304066B2 (en) | 2007-12-04 |
IL158574A0 (en) | 2004-05-12 |
US20040220408A1 (en) | 2004-11-04 |
EP1397355A1 (en) | 2004-03-17 |
DE60233656D1 (de) | 2009-10-22 |
MXPA03010669A (es) | 2004-07-01 |
US20080090842A1 (en) | 2008-04-17 |
BR0209930A (pt) | 2004-03-30 |
ATE442362T1 (de) | 2009-09-15 |
HK1066216A1 (en) | 2005-03-18 |
CN1509283A (zh) | 2004-06-30 |
CZ20033190A3 (cs) | 2004-06-16 |
JP2005508859A (ja) | 2005-04-07 |
HUP0400021A3 (en) | 2008-03-28 |
WO2002094813A1 (en) | 2002-11-28 |
EP1397355B1 (en) | 2009-09-09 |
US7807682B2 (en) | 2010-10-05 |
RU2292344C2 (ru) | 2007-01-27 |
HUP0400021A2 (hu) | 2004-04-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL158574A0 (en) | Novel pyridyl cyanoguanidine compounds | |
MXPA05009359A (es) | Tetrahidroisoquinolinas 2,5- y 2,6 substituidas para uso como moduladores 5-ht6. | |
MXPA05013142A (es) | Compuestos de piridinio [1,2-a]pirimidin-4-ona como agentes anticancer. | |
UA84712C2 (en) | N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors | |
HK1086256A1 (en) | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors | |
MX2007000505A (es) | Derivados de oxindol sustituidos y medicamentos que contienen los mismos. | |
BG108269A (en) | Pyrazolopyrimidines as therapeutic agents | |
HK1080470A1 (en) | Heterocyclic compounds | |
MY144622A (en) | Agents for preventing and treating disorders involving modulation of the ryr receptors | |
BG108268A (en) | Pyrazolopyrimidines as therapeutic agents | |
HK1121440A1 (en) | Biphenyl derivatives and their use in treating hepatitis c | |
ATE302775T1 (de) | Carbolinderivate | |
MY130697A (en) | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines | |
AU2002249890A1 (en) | Carboline derivatives | |
MY138737A (en) | N3-substituted imidazopyridine c-kit inhibitors | |
AU2002213421A1 (en) | Condensed pyridoindole derivatives | |
WO2002070469A3 (en) | Selective pde3b inhibitors and use of the same in therapy | |
MXPA04007391A (es) | Heterociclos triciclicos fusionados utiles para el tratamiento de padecimientos hiper-proliferantes. | |
MXPA03002909A (es) | Compuestos quimicos. | |
AU2001263278A1 (en) | Cyclic gmp-specific phosphodiesterase inhibitors | |
IL161842A0 (en) | 2-Amino-4-heteroarylethyl-thiazoline derivatives and their use as inhibitors of inducible no-synthase | |
PL1791811T3 (pl) | Pochodne aminoalkoholi | |
MXPA03003971A (es) | Derivados de indol como inhibidores de pde5. | |
AU2001296699A1 (en) | Condensed pyrazindione derivatives as pde inhibitors | |
AU2001261707A1 (en) | Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |