PL3643718T3 - Związek heterocykliczny i jego zastosowanie jako dodatniego modulatora allosterycznego względem cholinergicznego receptora muskarynowego m1 - Google Patents
Związek heterocykliczny i jego zastosowanie jako dodatniego modulatora allosterycznego względem cholinergicznego receptora muskarynowego m1Info
- Publication number
- PL3643718T3 PL3643718T3 PL18819596.0T PL18819596T PL3643718T3 PL 3643718 T3 PL3643718 T3 PL 3643718T3 PL 18819596 T PL18819596 T PL 18819596T PL 3643718 T3 PL3643718 T3 PL 3643718T3
- Authority
- PL
- Poland
- Prior art keywords
- receptor
- heterocyclic compound
- positive allosteric
- allosteric modulator
- cholinergic muscarinic
- Prior art date
Links
- 102000007207 Muscarinic M1 Receptor Human genes 0.000 title 1
- 108010008406 Muscarinic M1 Receptor Proteins 0.000 title 1
- 230000001713 cholinergic effect Effects 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 229940126027 positive allosteric modulator Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017120859 | 2017-06-20 | ||
| JP2018005960 | 2018-01-17 | ||
| US201862683418P | 2018-06-11 | 2018-06-11 | |
| PCT/JP2018/023357 WO2018235838A1 (ja) | 2017-06-20 | 2018-06-19 | 複素環化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3643718T3 true PL3643718T3 (pl) | 2024-01-22 |
Family
ID=64737123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18819596.0T PL3643718T3 (pl) | 2017-06-20 | 2018-06-19 | Związek heterocykliczny i jego zastosowanie jako dodatniego modulatora allosterycznego względem cholinergicznego receptora muskarynowego m1 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11236099B2 (pl) |
| DK (1) | DK3643718T3 (pl) |
| ES (1) | ES2960408T3 (pl) |
| FI (1) | FI3643718T3 (pl) |
| HR (1) | HRP20231236T1 (pl) |
| HU (1) | HUE063823T2 (pl) |
| LT (1) | LT3643718T (pl) |
| MX (1) | MX2021015514A (pl) |
| PL (1) | PL3643718T3 (pl) |
| PT (1) | PT3643718T (pl) |
| RS (1) | RS64722B1 (pl) |
| SI (1) | SI3643718T1 (pl) |
| WO (1) | WO2018235838A1 (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114605069B (zh) * | 2016-08-26 | 2024-06-11 | 国立大学法人东京大学 | 光学玻璃、由光学玻璃构成的光学元件和光学装置 |
| NZ763341A (en) * | 2017-10-27 | 2023-03-31 | Suven Life Sciences Ltd | Polycyclic amides as muscarinic m1 receptor positive allosteric modulators |
| US11970483B2 (en) | 2018-09-28 | 2024-04-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US12162864B2 (en) * | 2018-09-28 | 2024-12-10 | Takeda Pharmaceutical Company Limited | Condensed-cyclic compound |
| US12012419B2 (en) | 2018-09-28 | 2024-06-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2992677B2 (ja) | 1995-06-05 | 1999-12-20 | 武田薬品工業株式会社 | 骨形成促進医薬組成物 |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| JP4710445B2 (ja) | 2004-07-08 | 2011-06-29 | 田辺三菱製薬株式会社 | 医薬組成物 |
| BR112012014180A2 (pt) | 2009-12-17 | 2015-09-15 | Merck Sharp & Dohme | composto, composição farmacêutica, uso da composição farmacêutica, e, método para tratar uma doença ou em distúrbio. |
| US8815902B2 (en) | 2010-06-15 | 2014-08-26 | Merck Sharp & Dohme Corp. | Tetrahydroquinoline amide M1 receptor positive allosteric modulators |
| EP2709621B1 (en) | 2011-05-17 | 2016-11-02 | Merck Sharp & Dohme Corp. | N-linked quinolineamide m1 receptor positive allosteric modulators |
| EP2821401B1 (en) | 2012-03-02 | 2020-09-09 | Takeda Pharmaceutical Company Limited | Dihydroquinolinone compounds as modulators of the muscarininc m1 receptor |
| EP2921480B1 (en) | 2012-11-19 | 2017-10-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| MX373274B (es) | 2014-04-23 | 2020-04-16 | Takeda Pharmaceuticals Co | Derivados de isoindolin-1-ona con actividad de modulador alostérico positivo del receptor colinérgico muscarínico m1 para el tratamiento de la enfermedad de alzheimer. |
| JP6531093B2 (ja) | 2014-05-16 | 2019-06-12 | 武田薬品工業株式会社 | 含窒素複素環化合物 |
| WO2015190564A1 (ja) | 2014-06-13 | 2015-12-17 | 武田薬品工業株式会社 | 含窒素複素環化合物 |
| WO2016009297A1 (en) * | 2014-07-18 | 2016-01-21 | Pfizer Inc. | Pyridine derivatives as muscarinic m1 receptor positive allosteric modulators |
| KR20180019234A (ko) | 2015-06-26 | 2018-02-23 | 다케다 야쿠힌 고교 가부시키가이샤 | 콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체 |
| WO2017069173A1 (ja) | 2015-10-20 | 2017-04-27 | 武田薬品工業株式会社 | 複素環化合物 |
| JP2017120859A (ja) | 2015-12-28 | 2017-07-06 | 帝人株式会社 | 組紐状圧電素子、組紐状圧電素子を用いた布帛状圧電素子およびそれらを用いたデバイス |
| EP3416639B1 (en) | 2016-02-16 | 2022-06-08 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
| EP3428150B1 (en) | 2016-03-11 | 2023-07-12 | Takeda Pharmaceutical Company Limited | Aromatic ring compound having a cholinergic muscarine m1 receptor positive allosteric modulator activity |
| JP2018005960A (ja) | 2016-07-01 | 2018-01-11 | エヌイーシー ショット コンポーネンツ株式会社 | 接触子を有する気密端子 |
| WO2018042632A1 (ja) * | 2016-09-02 | 2018-03-08 | 新電元工業株式会社 | Ｍｏｓｆｅｔ及び電力変換回路 |
| SMT202000554T1 (it) * | 2016-09-02 | 2020-11-10 | Suven Life Sciences Ltd | Modulatori allosterici positivi del recettore muscarinico m1 |
| US10899759B2 (en) | 2016-09-30 | 2021-01-26 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M1 |
| WO2018194181A1 (en) | 2017-04-18 | 2018-10-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds useful as modulators of acetylcholine receptors |
-
2018
- 2018-06-19 PT PT188195960T patent/PT3643718T/pt unknown
- 2018-06-19 SI SI201831003T patent/SI3643718T1/sl unknown
- 2018-06-19 ES ES18819596T patent/ES2960408T3/es active Active
- 2018-06-19 DK DK18819596.0T patent/DK3643718T3/da active
- 2018-06-19 US US16/622,632 patent/US11236099B2/en active Active
- 2018-06-19 HR HRP20231236TT patent/HRP20231236T1/hr unknown
- 2018-06-19 LT LTEPPCT/JP2018/023357T patent/LT3643718T/lt unknown
- 2018-06-19 RS RS20230955A patent/RS64722B1/sr unknown
- 2018-06-19 FI FIEP18819596.0T patent/FI3643718T3/fi active
- 2018-06-19 PL PL18819596.0T patent/PL3643718T3/pl unknown
- 2018-06-19 HU HUE18819596A patent/HUE063823T2/hu unknown
- 2018-06-19 WO PCT/JP2018/023357 patent/WO2018235838A1/ja not_active Ceased
-
2019
- 2019-12-19 MX MX2021015514A patent/MX2021015514A/es unknown
-
2021
- 2021-09-15 US US17/475,733 patent/US12378256B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK3643718T3 (da) | 2023-11-06 |
| US20220017530A1 (en) | 2022-01-20 |
| PT3643718T (pt) | 2023-10-26 |
| WO2018235838A1 (ja) | 2018-12-27 |
| US12378256B2 (en) | 2025-08-05 |
| US20210139491A1 (en) | 2021-05-13 |
| SI3643718T1 (sl) | 2023-11-30 |
| LT3643718T (lt) | 2023-10-25 |
| RS64722B1 (sr) | 2023-11-30 |
| FI3643718T3 (fi) | 2023-11-01 |
| HRP20231236T1 (hr) | 2024-02-16 |
| HUE063823T2 (hu) | 2024-02-28 |
| MX2021015514A (es) | 2022-02-22 |
| US11236099B2 (en) | 2022-02-01 |
| ES2960408T3 (es) | 2024-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201808219B (en) | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 | |
| IL261058A (en) | Positive allosteric modulators of the muscarinic acetylcholine m1 receptor | |
| HUE052749T2 (hu) | Meloxicamot és rizatriptant tartalmazó gyógyászati készítmények | |
| IL264951B (en) | Positive allosteric modulators of the m1 muscarinic receptor | |
| ZA202007986B (en) | Oxadiazoles as agonists of the muscarinic m1 and/or m4 receptor | |
| SI3643718T1 (sl) | Heterociklična spojina in njena uporaba kot pozitivni alosterični modulator holinergičnega muskarinskega receptorja M1 | |
| ZA202004532B (en) | Compositions for the management of hyperglycemia and related conditions | |
| IL273237A (en) | Novel heterocyclic compounds as MGLUR7 modulators | |
| ZA201708108B (en) | Muscarinic m1 receptor positive allosteric modulators | |
| IL257869A (en) | Fluoroindole derivatives as positive allosteric modulators for muscarinic receptor am.1 | |
| IL273748B (en) | Heteroaryl compounds as positive allosteric modulators of m1 muscarinic receptors | |
| ZA202102487B (en) | Pyrrolo-pyridazine derivatives as muscarinic m1 receptor positive allosteric modulators | |
| HK40039227A (en) | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 | |
| HK40038649A (en) | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 | |
| IL274708B (en) | Transduced azacyclics as positive allosteric modulators of the m1 muscarinic receptor | |
| HK40002190A (en) | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 | |
| HK40015440A (en) | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 | |
| HK40015439A (en) | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 | |
| HK40036603A (en) | Heterocyclic compounds and uses thereof |