PL3643718T3 - Związek heterocykliczny i jego zastosowanie jako dodatniego modulatora allosterycznego względem cholinergicznego receptora muskarynowego m1 - Google Patents
Związek heterocykliczny i jego zastosowanie jako dodatniego modulatora allosterycznego względem cholinergicznego receptora muskarynowego m1Info
- Publication number
- PL3643718T3 PL3643718T3 PL18819596.0T PL18819596T PL3643718T3 PL 3643718 T3 PL3643718 T3 PL 3643718T3 PL 18819596 T PL18819596 T PL 18819596T PL 3643718 T3 PL3643718 T3 PL 3643718T3
- Authority
- PL
- Poland
- Prior art keywords
- receptor
- heterocyclic compound
- positive allosteric
- allosteric modulator
- cholinergic muscarinic
- Prior art date
Links
- 102000007207 Muscarinic M1 Receptor Human genes 0.000 title 1
- 108010008406 Muscarinic M1 Receptor Proteins 0.000 title 1
- 230000001713 cholinergic effect Effects 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 229940126027 positive allosteric modulator Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017120859 | 2017-06-20 | ||
| JP2018005960 | 2018-01-17 | ||
| US201862683418P | 2018-06-11 | 2018-06-11 | |
| PCT/JP2018/023357 WO2018235838A1 (ja) | 2017-06-20 | 2018-06-19 | 複素環化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3643718T3 true PL3643718T3 (pl) | 2024-01-22 |
Family
ID=64737123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18819596.0T PL3643718T3 (pl) | 2017-06-20 | 2018-06-19 | Związek heterocykliczny i jego zastosowanie jako dodatniego modulatora allosterycznego względem cholinergicznego receptora muskarynowego m1 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11236099B2 (pl) |
| DK (1) | DK3643718T3 (pl) |
| ES (1) | ES2960408T3 (pl) |
| FI (1) | FI3643718T3 (pl) |
| HR (1) | HRP20231236T1 (pl) |
| HU (1) | HUE063823T2 (pl) |
| LT (1) | LT3643718T (pl) |
| MX (1) | MX2021015514A (pl) |
| PL (1) | PL3643718T3 (pl) |
| PT (1) | PT3643718T (pl) |
| RS (1) | RS64722B1 (pl) |
| SI (1) | SI3643718T1 (pl) |
| WO (1) | WO2018235838A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018037797A1 (ja) * | 2016-08-26 | 2018-03-01 | 国立大学法人東京大学 | 光学ガラス、光学ガラスからなる光学素子、及び光学装置 |
| JP7110338B2 (ja) * | 2017-10-27 | 2022-08-01 | スヴェン・ライフ・サイエンシーズ・リミテッド | ムスカリンｍ１受容体陽性アロステリックモジュレーターである多環式アミド類 |
| WO2020067457A1 (ja) * | 2018-09-28 | 2020-04-02 | 武田薬品工業株式会社 | 縮合環化合物 |
| US11970483B2 (en) | 2018-09-28 | 2024-04-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2992677B2 (ja) | 1995-06-05 | 1999-12-20 | 武田薬品工業株式会社 | 骨形成促進医薬組成物 |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| JP4710445B2 (ja) | 2004-07-08 | 2011-06-29 | 田辺三菱製薬株式会社 | 医薬組成物 |
| EP2512243B1 (en) | 2009-12-17 | 2016-04-06 | Merck Sharp & Dohme Corp. | Quinoline amide m1 receptor positive allosteric modulators |
| WO2011159554A1 (en) | 2010-06-15 | 2011-12-22 | Merck Sharp & Dohme Corp. | Tetrahydroquinoline amide m1 receptor positive allosteric modulators |
| US8940765B2 (en) | 2011-05-17 | 2015-01-27 | Merck Sharp & Dohme Corp. | N-linked quinolineamide M1 receptor positive allosteric modulators |
| JP6211509B2 (ja) | 2012-03-02 | 2017-10-11 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| US9777005B2 (en) | 2012-11-19 | 2017-10-03 | Takeda Pharmaceutical Company Limited | Bicyclic heterocyclic compound containing a substituted pyrrole ring |
| SG11201608785PA (en) | 2014-04-23 | 2016-11-29 | Takeda Pharmaceuticals Co | Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease |
| US10208046B2 (en) | 2014-05-16 | 2019-02-19 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| WO2015190564A1 (ja) | 2014-06-13 | 2015-12-17 | 武田薬品工業株式会社 | 含窒素複素環化合物 |
| WO2016009297A1 (en) | 2014-07-18 | 2016-01-21 | Pfizer Inc. | Pyridine derivatives as muscarinic m1 receptor positive allosteric modulators |
| KR20180019234A (ko) | 2015-06-26 | 2018-02-23 | 다케다 야쿠힌 고교 가부시키가이샤 | 콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체 |
| US10548899B2 (en) | 2015-10-20 | 2020-02-04 | Takeda Pharmaceutical Company Limited | Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity |
| JP2017120859A (ja) | 2015-12-28 | 2017-07-06 | 帝人株式会社 | 組紐状圧電素子、組紐状圧電素子を用いた布帛状圧電素子およびそれらを用いたデバイス |
| CA3014791A1 (en) * | 2016-02-16 | 2017-08-24 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
| JP6860551B2 (ja) | 2016-03-11 | 2021-04-14 | 武田薬品工業株式会社 | 芳香環化合物 |
| JP2018005960A (ja) | 2016-07-01 | 2018-01-11 | エヌイーシー ショット コンポーネンツ株式会社 | 接触子を有する気密端子 |
| CN109952302B (zh) | 2016-09-02 | 2020-11-24 | 苏文生命科学有限公司 | 毒蕈碱m1受体正向别构调节剂 |
| WO2018063552A1 (en) | 2016-09-30 | 2018-04-05 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
| JP7145875B2 (ja) | 2017-04-18 | 2022-10-03 | 武田薬品工業株式会社 | アセチルコリン受容体のモジュレーターとして有用な複素環化合物 |
-
2018
- 2018-06-19 SI SI201831003T patent/SI3643718T1/sl unknown
- 2018-06-19 US US16/622,632 patent/US11236099B2/en active Active
- 2018-06-19 PL PL18819596.0T patent/PL3643718T3/pl unknown
- 2018-06-19 HR HRP20231236TT patent/HRP20231236T1/hr unknown
- 2018-06-19 HU HUE18819596A patent/HUE063823T2/hu unknown
- 2018-06-19 RS RS20230955A patent/RS64722B1/sr unknown
- 2018-06-19 LT LTEPPCT/JP2018/023357T patent/LT3643718T/lt unknown
- 2018-06-19 FI FIEP18819596.0T patent/FI3643718T3/fi active
- 2018-06-19 PT PT188195960T patent/PT3643718T/pt unknown
- 2018-06-19 DK DK18819596.0T patent/DK3643718T3/da active
- 2018-06-19 ES ES18819596T patent/ES2960408T3/es active Active
- 2018-06-19 WO PCT/JP2018/023357 patent/WO2018235838A1/ja active Application Filing
-
2019
- 2019-12-19 MX MX2021015514A patent/MX2021015514A/es unknown
-
2021
- 2021-09-15 US US17/475,733 patent/US20220017530A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20231236T1 (hr) | 2024-02-16 |
| RS64722B1 (sr) | 2023-11-30 |
| US20210139491A1 (en) | 2021-05-13 |
| SI3643718T1 (sl) | 2023-11-30 |
| LT3643718T (lt) | 2023-10-25 |
| HUE063823T2 (hu) | 2024-02-28 |
| US20220017530A1 (en) | 2022-01-20 |
| US11236099B2 (en) | 2022-02-01 |
| ES2960408T3 (es) | 2024-03-04 |
| DK3643718T3 (da) | 2023-11-06 |
| FI3643718T3 (fi) | 2023-11-01 |
| MX2021015514A (es) | 2022-02-22 |
| PT3643718T (pt) | 2023-10-26 |
| WO2018235838A1 (ja) | 2018-12-27 |
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