PL3500586T3 - Sposób ciągły zmniejszania heterogeniczności białka terapeutycznego - Google Patents
Sposób ciągły zmniejszania heterogeniczności białka terapeutycznegoInfo
- Publication number
- PL3500586T3 PL3500586T3 PL17804655T PL17804655T PL3500586T3 PL 3500586 T3 PL3500586 T3 PL 3500586T3 PL 17804655 T PL17804655 T PL 17804655T PL 17804655 T PL17804655 T PL 17804655T PL 3500586 T3 PL3500586 T3 PL 3500586T3
- Authority
- PL
- Poland
- Prior art keywords
- continuous process
- therapeutic protein
- reducing heterogeneity
- heterogeneity
- reducing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201621035458 | 2016-10-17 | ||
| PCT/IB2017/056395 WO2018073717A1 (en) | 2016-10-17 | 2017-10-16 | Continuous process for reducing heterogeneity of therapeutic protein |
| EP17804655.3A EP3500586B1 (en) | 2016-10-17 | 2017-10-16 | Continuous process for reducing heterogeneity of therapeutic protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3500586T3 true PL3500586T3 (pl) | 2021-09-27 |
Family
ID=60473571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17804655T PL3500586T3 (pl) | 2016-10-17 | 2017-10-16 | Sposób ciągły zmniejszania heterogeniczności białka terapeutycznego |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11618768B2 (pl) |
| EP (1) | EP3500586B1 (pl) |
| JP (1) | JP6976343B2 (pl) |
| KR (1) | KR102543033B1 (pl) |
| CN (1) | CN109843904A (pl) |
| AU (1) | AU2017345387B2 (pl) |
| DK (1) | DK3500586T3 (pl) |
| EA (1) | EA201990593A1 (pl) |
| ES (1) | ES2876416T3 (pl) |
| HR (1) | HRP20210830T1 (pl) |
| HU (1) | HUE054420T2 (pl) |
| PL (1) | PL3500586T3 (pl) |
| PT (1) | PT3500586T (pl) |
| WO (1) | WO2018073717A1 (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11884698B2 (en) * | 2018-07-02 | 2024-01-30 | Regeneron Pharmaceuticals, Inc. | Systems and methods for preparing a polypeptide from a mixture |
| US20220323937A1 (en) * | 2019-09-24 | 2022-10-13 | Regeneron Pharmaceuticals, Inc. | Systems and methods for chromatography use and regeneration |
| WO2021139720A1 (zh) * | 2020-01-08 | 2021-07-15 | 信达生物制药(苏州)有限公司 | 阿达木单抗纯化方法及其稳定组合物 |
| WO2022066595A1 (en) * | 2020-09-22 | 2022-03-31 | Bristol-Myers Squibb Company | Methods for producing therapeutic proteins |
| CN115475258A (zh) * | 2022-09-06 | 2022-12-16 | 江苏丰华生物制药有限公司 | 一种注射用替奈普酶纯化工艺 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1332367C (en) * | 1988-09-28 | 1994-10-11 | Richard Mark Bartholomew | Method for the reduction of heterogeneity of monoclonal antibodies |
| US5126250A (en) | 1988-09-28 | 1992-06-30 | Eli Lilly And Company | Method for the reduction of heterogeneity of monoclonal antibodies |
| BRPI0823004B8 (pt) * | 2008-08-07 | 2021-05-25 | Biocon Ltd | processo para preparação de compostos de insulina |
| EP2450375A1 (en) | 2010-11-09 | 2012-05-09 | Sandoz Gmbh | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
| KR101591671B1 (ko) | 2011-04-29 | 2016-02-04 | 바이오콘 리서치 리미티드 | 항체의 이질성을 감소시키는 방법 및 그 항체의 제조방법 |
| US20140371427A1 (en) * | 2011-12-07 | 2014-12-18 | Amgen Inc. | IgG2 DISULFIDE ISOFORM SEPARATION |
| US9181572B2 (en) * | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US20150267237A1 (en) * | 2012-04-24 | 2015-09-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
| WO2014137903A2 (en) * | 2013-03-08 | 2014-09-12 | Genzyme Corporation | Integrated continuous manufacturing of therapeutic protein drug substances |
| CN105483193B (zh) * | 2015-11-24 | 2019-03-29 | 上海联合赛尔生物工程有限公司 | 从含酶切位点的融合蛋白中纯化蛋白的方法及试剂盒 |
-
2017
- 2017-10-16 PT PT178046553T patent/PT3500586T/pt unknown
- 2017-10-16 PL PL17804655T patent/PL3500586T3/pl unknown
- 2017-10-16 US US16/340,822 patent/US11618768B2/en active Active
- 2017-10-16 EP EP17804655.3A patent/EP3500586B1/en active Active
- 2017-10-16 JP JP2019541899A patent/JP6976343B2/ja active Active
- 2017-10-16 HU HUE17804655A patent/HUE054420T2/hu unknown
- 2017-10-16 AU AU2017345387A patent/AU2017345387B2/en active Active
- 2017-10-16 CN CN201780063678.6A patent/CN109843904A/zh active Pending
- 2017-10-16 KR KR1020197010561A patent/KR102543033B1/ko active IP Right Grant
- 2017-10-16 WO PCT/IB2017/056395 patent/WO2018073717A1/en unknown
- 2017-10-16 ES ES17804655T patent/ES2876416T3/es active Active
- 2017-10-16 DK DK17804655.3T patent/DK3500586T3/da active
- 2017-10-16 EA EA201990593A patent/EA201990593A1/ru unknown
-
2021
- 2021-05-24 HR HRP20210830TT patent/HRP20210830T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20210830T1 (hr) | 2021-08-20 |
| US20190263855A1 (en) | 2019-08-29 |
| EA201990593A1 (ru) | 2019-10-31 |
| CN109843904A (zh) | 2019-06-04 |
| AU2017345387A1 (en) | 2019-04-11 |
| EP3500586A1 (en) | 2019-06-26 |
| KR20190064591A (ko) | 2019-06-10 |
| ES2876416T3 (es) | 2021-11-12 |
| AU2017345387B2 (en) | 2024-09-19 |
| DK3500586T3 (da) | 2021-05-31 |
| US11618768B2 (en) | 2023-04-04 |
| HUE054420T2 (hu) | 2021-09-28 |
| EP3500586B1 (en) | 2021-02-24 |
| JP2019533724A (ja) | 2019-11-21 |
| WO2018073717A1 (en) | 2018-04-26 |
| KR102543033B1 (ko) | 2023-06-12 |
| PT3500586T (pt) | 2021-06-17 |
| JP6976343B2 (ja) | 2021-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1245829A1 (zh) | 受控消除治療性細胞的方法 | |
| HK1251614A1 (zh) | 用於惡性腫瘤的治療的方法 | |
| IL247508A0 (en) | A method for preparing human plasma proteins | |
| HK1256795A1 (zh) | 可用於治療自身免疫疾病的二吡唑基衍生物 | |
| SG11201607130RA (en) | Combination method for treatment of cancer | |
| HUE054420T2 (hu) | Folyamatos eljárás terápiás fehérje heterogenitásának csökkentésére | |
| PL3297975T3 (pl) | Sposób kompleksowej utylizacji fosfogipsów | |
| IL267622A (en) | Method for modifying the therapeutic effects of drugs | |
| HK1258994A1 (zh) | 用於疾病治療的方法 | |
| IL254883B (en) | A method for protein purification | |
| HK1247818A1 (zh) | 治療疾病的方法 | |
| GB201515557D0 (en) | Method of sequencing | |
| GB201515558D0 (en) | Method of sequencing | |
| HK1245671A1 (zh) | 使用白細胞介素-10治療疾病和病症的方法 | |
| IL252712A0 (en) | Method for protein production | |
| GB201602802D0 (en) | Method of treatment | |
| HK1246679A1 (zh) | 絲蟲病的治療 | |
| HK1243937A1 (zh) | 治療疾病的方法 | |
| IL253077A0 (en) | Process and intermediates for the preparation of Fermpanel | |
| IL249610A (en) | Chimeric proteins for cancer treatment | |
| HK1256714A1 (zh) | 製備治療性蛋白質的方法 | |
| IL256707B (en) | A method for the production of recombinant proteins | |
| IL256706B (en) | A method for making recombinant proteins | |
| GB201512139D0 (en) | Methods of treatment | |
| EP3368158A4 (en) | THIRD SPACE PROCESSING METHOD |