DK3500586T3 - Kontinuerlig fremgangsmåde til at reducere heterogenitet af terapeutisk protein - Google Patents
Kontinuerlig fremgangsmåde til at reducere heterogenitet af terapeutisk protein Download PDFInfo
- Publication number
- DK3500586T3 DK3500586T3 DK17804655.3T DK17804655T DK3500586T3 DK 3500586 T3 DK3500586 T3 DK 3500586T3 DK 17804655 T DK17804655 T DK 17804655T DK 3500586 T3 DK3500586 T3 DK 3500586T3
- Authority
- DK
- Denmark
- Prior art keywords
- heterogenity
- reduce
- therapeutic protein
- continuous procedure
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201621035458 | 2016-10-17 | ||
| PCT/IB2017/056395 WO2018073717A1 (en) | 2016-10-17 | 2017-10-16 | Continuous process for reducing heterogeneity of therapeutic protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3500586T3 true DK3500586T3 (da) | 2021-05-31 |
Family
ID=60473571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17804655.3T DK3500586T3 (da) | 2016-10-17 | 2017-10-16 | Kontinuerlig fremgangsmåde til at reducere heterogenitet af terapeutisk protein |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11618768B2 (da) |
| EP (1) | EP3500586B1 (da) |
| JP (1) | JP6976343B2 (da) |
| KR (1) | KR102543033B1 (da) |
| CN (1) | CN109843904A (da) |
| AU (1) | AU2017345387B2 (da) |
| DK (1) | DK3500586T3 (da) |
| EA (1) | EA201990593A1 (da) |
| ES (1) | ES2876416T3 (da) |
| HR (1) | HRP20210830T1 (da) |
| HU (1) | HUE054420T2 (da) |
| PL (1) | PL3500586T3 (da) |
| PT (1) | PT3500586T (da) |
| WO (1) | WO2018073717A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11884698B2 (en) * | 2018-07-02 | 2024-01-30 | Regeneron Pharmaceuticals, Inc. | Systems and methods for preparing a polypeptide from a mixture |
| KR20220066393A (ko) * | 2019-09-24 | 2022-05-24 | 리제너론 파아마슈티컬스, 인크. | 크로마토그래피의 사용 및 재생을 위한 시스템 및 방법 |
| WO2021139720A1 (zh) * | 2020-01-08 | 2021-07-15 | 信达生物制药(苏州)有限公司 | 阿达木单抗纯化方法及其稳定组合物 |
| EP4217383A1 (en) * | 2020-09-22 | 2023-08-02 | Bristol-Myers Squibb Company | Methods for producing therapeutic proteins |
| CN115475258A (zh) * | 2022-09-06 | 2022-12-16 | 江苏丰华生物制药有限公司 | 一种注射用替奈普酶纯化工艺 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1332367C (en) * | 1988-09-28 | 1994-10-11 | Richard Mark Bartholomew | Method for the reduction of heterogeneity of monoclonal antibodies |
| US5126250A (en) | 1988-09-28 | 1992-06-30 | Eli Lilly And Company | Method for the reduction of heterogeneity of monoclonal antibodies |
| MX2011001408A (es) * | 2008-08-07 | 2011-05-02 | Biocon Ltd | Proceso para la preparacion de compuestos de insulina. |
| EP2450375A1 (en) | 2010-11-09 | 2012-05-09 | Sandoz Gmbh | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
| ES2560470T3 (es) | 2011-04-29 | 2016-02-19 | Biocon Research Limited | Un método para reducir la heterogeneidad de anticuerpos y un proceso de producción de dichos anticuerpos |
| EP2788097A4 (en) * | 2011-12-07 | 2015-09-09 | Amgen Inc | IGG2 DISULFIDE ISOFORMATION SEPARATION |
| WO2013158273A1 (en) * | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US20150267237A1 (en) * | 2012-04-24 | 2015-09-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
| SG10201709131UA (en) * | 2013-03-08 | 2017-12-28 | Genzyme Corp | Continuous purification of therapeutic proteins |
| CN105483193B (zh) * | 2015-11-24 | 2019-03-29 | 上海联合赛尔生物工程有限公司 | 从含酶切位点的融合蛋白中纯化蛋白的方法及试剂盒 |
-
2017
- 2017-10-16 ES ES17804655T patent/ES2876416T3/es active Active
- 2017-10-16 PL PL17804655T patent/PL3500586T3/pl unknown
- 2017-10-16 US US16/340,822 patent/US11618768B2/en active Active
- 2017-10-16 DK DK17804655.3T patent/DK3500586T3/da active
- 2017-10-16 WO PCT/IB2017/056395 patent/WO2018073717A1/en unknown
- 2017-10-16 JP JP2019541899A patent/JP6976343B2/ja active Active
- 2017-10-16 HU HUE17804655A patent/HUE054420T2/hu unknown
- 2017-10-16 CN CN201780063678.6A patent/CN109843904A/zh active Pending
- 2017-10-16 EP EP17804655.3A patent/EP3500586B1/en active Active
- 2017-10-16 EA EA201990593A patent/EA201990593A1/ru unknown
- 2017-10-16 AU AU2017345387A patent/AU2017345387B2/en active Active
- 2017-10-16 KR KR1020197010561A patent/KR102543033B1/ko active IP Right Grant
- 2017-10-16 PT PT178046553T patent/PT3500586T/pt unknown
-
2021
- 2021-05-24 HR HRP20210830TT patent/HRP20210830T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019533724A (ja) | 2019-11-21 |
| AU2017345387B2 (en) | 2024-09-19 |
| ES2876416T3 (es) | 2021-11-12 |
| AU2017345387A1 (en) | 2019-04-11 |
| HRP20210830T1 (hr) | 2021-08-20 |
| JP6976343B2 (ja) | 2021-12-08 |
| EP3500586B1 (en) | 2021-02-24 |
| US20190263855A1 (en) | 2019-08-29 |
| US11618768B2 (en) | 2023-04-04 |
| WO2018073717A1 (en) | 2018-04-26 |
| PT3500586T (pt) | 2021-06-17 |
| KR102543033B1 (ko) | 2023-06-12 |
| PL3500586T3 (pl) | 2021-09-27 |
| HUE054420T2 (hu) | 2021-09-28 |
| EA201990593A1 (ru) | 2019-10-31 |
| CN109843904A (zh) | 2019-06-04 |
| KR20190064591A (ko) | 2019-06-10 |
| EP3500586A1 (en) | 2019-06-26 |
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