PL3371152T3 - Kompozycje zawierające inhibitor specyficznej dla lizyny demetylazy-1 mający pierścień pirymidynowy i jego zastosowanie w leczeniu nowotworów - Google Patents
Kompozycje zawierające inhibitor specyficznej dla lizyny demetylazy-1 mający pierścień pirymidynowy i jego zastosowanie w leczeniu nowotworówInfo
- Publication number
- PL3371152T3 PL3371152T3 PL16863111T PL16863111T PL3371152T3 PL 3371152 T3 PL3371152 T3 PL 3371152T3 PL 16863111 T PL16863111 T PL 16863111T PL 16863111 T PL16863111 T PL 16863111T PL 3371152 T3 PL3371152 T3 PL 3371152T3
- Authority
- PL
- Poland
- Prior art keywords
- cancer
- inhibitor
- compositions
- treatment
- pyrimidine ring
- Prior art date
Links
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title 1
- 239000004472 Lysine Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000000714 pyrimidinyl group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562251507P | 2015-11-05 | 2015-11-05 | |
| PCT/US2016/060694 WO2017079670A1 (en) | 2015-11-05 | 2016-11-04 | Compositions comprising an inhibitor of lysine specific demethylase-1 |
| EP16863111.7A EP3371152B1 (en) | 2015-11-05 | 2016-11-04 | Compositions comprising an inhibitor of lysine specific demethylase-1 having a pyrimidine ring and its use in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3371152T3 true PL3371152T3 (pl) | 2021-06-28 |
Family
ID=58662888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16863111T PL3371152T3 (pl) | 2015-11-05 | 2016-11-04 | Kompozycje zawierające inhibitor specyficznej dla lizyny demetylazy-1 mający pierścień pirymidynowy i jego zastosowanie w leczeniu nowotworów |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9828358B2 (pl) |
| EP (1) | EP3371152B1 (pl) |
| JP (1) | JP6995043B2 (pl) |
| CN (1) | CN108473442B (pl) |
| AR (1) | AR106612A1 (pl) |
| AU (1) | AU2016349707B2 (pl) |
| CA (1) | CA3004300C (pl) |
| CY (1) | CY1124078T1 (pl) |
| DK (1) | DK3371152T3 (pl) |
| ES (1) | ES2846951T3 (pl) |
| HR (1) | HRP20210144T8 (pl) |
| HU (1) | HUE053449T2 (pl) |
| LT (1) | LT3371152T (pl) |
| MX (2) | MX373363B (pl) |
| PL (1) | PL3371152T3 (pl) |
| PT (1) | PT3371152T (pl) |
| RS (1) | RS61404B1 (pl) |
| SI (1) | SI3371152T1 (pl) |
| SM (1) | SMT202100044T1 (pl) |
| TW (1) | TW201720808A (pl) |
| WO (1) | WO2017079670A1 (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20161438A1 (es) | 2014-05-01 | 2017-01-18 | Celgene Quanticel Res Inc | Inhibidores de desmetilasa 1 especifica a lisina |
| ES2846951T3 (es) * | 2015-11-05 | 2021-07-30 | Celgene Quanticel Res Inc | Composiciones que comprenden un inhibidor de desmetilasa-1 específica para lisina, que tiene un anillo de pirimidina, y su uso en el tratamiento del cáncer |
| WO2018083189A1 (en) | 2016-11-03 | 2018-05-11 | Oryzon Genomics, S.A. | Biomarkers for determining responsiveness to lsd1 inhibitors |
| US20200069677A1 (en) | 2016-12-09 | 2020-03-05 | Constellation Pharmaceuticals, Inc. | Markers for personalized cancer treatment with lsd1 inhibitors |
| CA3071804A1 (en) | 2017-08-03 | 2019-02-07 | Oryzon Genomics, S.A. | Use of a kdm1a inhibitor in the treatment of behavior alterations |
| CN113631164A (zh) | 2019-03-20 | 2021-11-09 | 奥莱松基因组股份有限公司 | 使用kdm1a抑制剂如化合物伐菲德司他治疗注意缺陷多动症的方法 |
| HRP20260110T1 (hr) | 2019-03-20 | 2026-03-13 | Oryzon Genomics, S.A. | Vafidemstat za liječenje neagresivnih simptoma graničnog poremećaja osobnosti |
| CA3143030A1 (en) * | 2019-06-13 | 2020-12-17 | Celgene Corporation | Methods of treating cancer by targeting cold tumors |
| JP2022537384A (ja) * | 2019-06-20 | 2022-08-25 | セルジーン コーポレーション | ベネトクラクス、ギルテリチニブ、ミドスタウリン、または白血病もしくは骨髄異形成症候群を治療するための他の化合物との組み合わせにおけるアザシチジン |
| JP2022546908A (ja) | 2019-07-05 | 2022-11-10 | オリゾン・ゲノミクス・ソシエダッド・アノニマ | Ｋｄｍ１ａ阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法 |
| EP4161507A1 (en) * | 2020-06-05 | 2023-04-12 | Celgene Quanticel Research, Inc. | Methods of treating prostate cancer |
| ES2919083R1 (es) * | 2020-06-29 | 2022-07-26 | Celgene Quanticel Res Inc | Métodos de tratamiento de cáncer de próstata |
| MX2023011779A (es) | 2021-04-08 | 2023-11-22 | Oryzon Genomics Sa | Combinaciones de inhibidores de lsd1 para el tratamiento de canceres mieloides. |
| CN119497613A (zh) | 2022-05-09 | 2025-02-21 | 奥莱松基因组股份有限公司 | 使用lsd1抑制剂治疗nf1-突变肿瘤的方法 |
| US20250275969A1 (en) | 2022-05-09 | 2025-09-04 | Oryzon Genomics, S.A. | Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors |
| CN120529900A (zh) | 2022-11-24 | 2025-08-22 | 奥莱松基因组股份有限公司 | 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| CA2513414A1 (en) * | 2002-04-10 | 2003-10-16 | Orchid Chemicals & Pharmaceuticals Limited | Pyrimidinedione derivatives useful for the treatment of inflammation and immunological diseases |
| AU2003216591A1 (en) | 2002-04-10 | 2003-10-20 | Orichid Chemicals And Pharmaceuticals Limited | Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological |
| US20070270446A1 (en) | 2004-10-06 | 2007-11-22 | Smithkline Beecham Corporation | Reversed Pyrimidinone Compounds as Calcilytics |
| UY32158A (es) * | 2008-10-03 | 2010-04-30 | Astrazeneca Ab | Derivados heterociclicos y metodos de uso de los mismos |
| US10093646B2 (en) * | 2014-01-17 | 2018-10-09 | Novartis Ag | 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2 |
| PE20161438A1 (es) * | 2014-05-01 | 2017-01-18 | Celgene Quanticel Res Inc | Inhibidores de desmetilasa 1 especifica a lisina |
| ES2846951T3 (es) * | 2015-11-05 | 2021-07-30 | Celgene Quanticel Res Inc | Composiciones que comprenden un inhibidor de desmetilasa-1 específica para lisina, que tiene un anillo de pirimidina, y su uso en el tratamiento del cáncer |
-
2016
- 2016-11-04 ES ES16863111T patent/ES2846951T3/es active Active
- 2016-11-04 SI SI201631055T patent/SI3371152T1/sl unknown
- 2016-11-04 PL PL16863111T patent/PL3371152T3/pl unknown
- 2016-11-04 WO PCT/US2016/060694 patent/WO2017079670A1/en not_active Ceased
- 2016-11-04 US US15/344,426 patent/US9828358B2/en active Active
- 2016-11-04 LT LTEP16863111.7T patent/LT3371152T/lt unknown
- 2016-11-04 HU HUE16863111A patent/HUE053449T2/hu unknown
- 2016-11-04 HR HRP20210144TT patent/HRP20210144T8/hr unknown
- 2016-11-04 MX MX2018005620A patent/MX373363B/es active IP Right Grant
- 2016-11-04 JP JP2018522953A patent/JP6995043B2/ja active Active
- 2016-11-04 CA CA3004300A patent/CA3004300C/en active Active
- 2016-11-04 EP EP16863111.7A patent/EP3371152B1/en active Active
- 2016-11-04 SM SM20210044T patent/SMT202100044T1/it unknown
- 2016-11-04 PT PT168631117T patent/PT3371152T/pt unknown
- 2016-11-04 AU AU2016349707A patent/AU2016349707B2/en not_active Ceased
- 2016-11-04 RS RS20210094A patent/RS61404B1/sr unknown
- 2016-11-04 CN CN201680076854.5A patent/CN108473442B/zh active Active
- 2016-11-04 DK DK16863111.7T patent/DK3371152T3/da active
- 2016-11-04 MX MX2020004894A patent/MX387607B/es unknown
- 2016-11-07 TW TW105136105A patent/TW201720808A/zh unknown
- 2016-11-07 AR ARP160103391A patent/AR106612A1/es unknown
-
2017
- 2017-10-25 US US15/793,512 patent/US10047069B2/en active Active
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2018
- 2018-07-10 US US16/032,002 patent/US10316016B2/en active Active
-
2019
- 2019-06-10 US US16/436,541 patent/US10703739B2/en active Active
-
2021
- 2021-01-28 CY CY20211100072T patent/CY1124078T1/el unknown
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