PL3172216T3 - Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie - Google Patents

Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie

Info

Publication number
PL3172216T3
PL3172216T3 PL14772458T PL14772458T PL3172216T3 PL 3172216 T3 PL3172216 T3 PL 3172216T3 PL 14772458 T PL14772458 T PL 14772458T PL 14772458 T PL14772458 T PL 14772458T PL 3172216 T3 PL3172216 T3 PL 3172216T3
Authority
PL
Poland
Prior art keywords
déoxy
anhydro
manufacturing process
cytotoxic activity
fluorouridine derivatives
Prior art date
Application number
PL14772458T
Other languages
English (en)
Inventor
Lech Celewicz
Karol KACPRZAK
Marta LEWANDOWSKA
Piotr RUSZKOWSKI
Original Assignee
Univ Im Adama Mickiewicza W Poznaniu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Im Adama Mickiewicza W Poznaniu filed Critical Univ Im Adama Mickiewicza W Poznaniu
Publication of PL3172216T3 publication Critical patent/PL3172216T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PL14772458T 2014-07-24 2014-08-22 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie PL3172216T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL408981A PL225283B1 (pl) 2014-07-24 2014-07-24 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie
PCT/PL2014/050050 WO2015050468A1 (en) 2014-07-24 2014-08-22 2,3'-Anhydro-2'-deoxy-5-fluorouridine derivatives with cytotoxic activity, a manufacturing process and application
EP14772458.7A EP3172216B1 (en) 2014-07-24 2014-08-22 2,3'-anhydro-2'-déoxy-5-fluorouridine derivatives with cytotoxic activity, a manufacturing process and use thereof

Publications (1)

Publication Number Publication Date
PL3172216T3 true PL3172216T3 (pl) 2019-04-30

Family

ID=52778964

Family Applications (2)

Application Number Title Priority Date Filing Date
PL408981A PL225283B1 (pl) 2014-07-24 2014-07-24 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie
PL14772458T PL3172216T3 (pl) 2014-07-24 2014-08-22 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL408981A PL225283B1 (pl) 2014-07-24 2014-07-24 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie

Country Status (7)

Country Link
US (1) US9260468B1 (pl)
EP (1) EP3172216B1 (pl)
JP (1) JP5894351B2 (pl)
CN (1) CN105722845A (pl)
CA (1) CA2887025C (pl)
PL (2) PL225283B1 (pl)
WO (1) WO2015050468A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114644651A (zh) * 2022-04-13 2022-06-21 中国人民解放军军事科学院军事医学研究院 芳氧基磷酰化氨基酸酯化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102464688A (zh) * 2010-11-19 2012-05-23 医影生物医药科技(上海)有限公司 胸苷环磷酸酯化合物及其抗肿瘤用途
CN103403014B (zh) * 2011-01-03 2016-07-06 河南美泰宝生物制药有限公司 O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途
DK3031812T3 (en) * 2011-03-01 2018-09-17 NuCana plc CHEMICAL COMPOUNDS

Also Published As

Publication number Publication date
CN105722845A (zh) 2016-06-29
JP5894351B2 (ja) 2016-03-30
JP2015537040A (ja) 2015-12-24
EP3172216A1 (en) 2017-05-31
CA2887025A1 (en) 2015-04-09
WO2015050468A1 (en) 2015-04-09
CA2887025C (en) 2016-01-05
US9260468B1 (en) 2016-02-16
EP3172216B1 (en) 2018-10-10
US20160024133A1 (en) 2016-01-28
PL225283B1 (pl) 2017-03-31
PL408981A1 (pl) 2015-06-22

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