PL3141541T3 - Pochodna cykloheksylopirydyny - Google Patents
Pochodna cykloheksylopirydynyInfo
- Publication number
- PL3141541T3 PL3141541T3 PL15789561T PL15789561T PL3141541T3 PL 3141541 T3 PL3141541 T3 PL 3141541T3 PL 15789561 T PL15789561 T PL 15789561T PL 15789561 T PL15789561 T PL 15789561T PL 3141541 T3 PL3141541 T3 PL 3141541T3
- Authority
- PL
- Poland
- Prior art keywords
- cyclohexyl
- pyridine derivative
- pyridine
- derivative
- Prior art date
Links
- HUTHUTALXJNNRS-UHFFFAOYSA-N 2-cyclohexylpyridine Chemical class C1CCCCC1C1=CC=CC=N1 HUTHUTALXJNNRS-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014095776 | 2014-05-07 | ||
| EP15789561.6A EP3141541B1 (en) | 2014-05-07 | 2015-05-07 | Cyclohexyl-pyridine derivative |
| PCT/JP2015/063154 WO2015170693A1 (ja) | 2014-05-07 | 2015-05-07 | シクロヘキシルピリジン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3141541T3 true PL3141541T3 (pl) | 2019-05-31 |
Family
ID=54392543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15789561T PL3141541T3 (pl) | 2014-05-07 | 2015-05-07 | Pochodna cykloheksylopirydyny |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9708266B2 (pl) |
| EP (1) | EP3141541B1 (pl) |
| JP (1) | JP5847362B1 (pl) |
| KR (1) | KR102061544B1 (pl) |
| CN (1) | CN106414406B (pl) |
| AU (1) | AU2015257007B2 (pl) |
| BR (1) | BR112016025984B1 (pl) |
| CA (1) | CA2946523C (pl) |
| DK (1) | DK3141541T3 (pl) |
| ES (1) | ES2704709T3 (pl) |
| HU (1) | HUE042659T2 (pl) |
| IL (1) | IL248772B (pl) |
| MX (1) | MX2016014566A (pl) |
| PL (1) | PL3141541T3 (pl) |
| PT (1) | PT3141541T (pl) |
| RU (1) | RU2681316C2 (pl) |
| SG (1) | SG11201609298TA (pl) |
| TW (1) | TWI649307B (pl) |
| WO (1) | WO2015170693A1 (pl) |
| ZA (1) | ZA201607847B (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6609253B2 (ja) * | 2014-08-06 | 2019-11-20 | キッセイ薬品工業株式会社 | シアノチオフェン誘導体 |
| ES2813596T3 (es) * | 2015-12-07 | 2021-03-24 | Kissei Pharmaceutical | Antagonista del receptor NK1 |
| KR20200020911A (ko) | 2017-06-30 | 2020-02-26 | 바이엘 애니멀 헬스 게엠베하 | 새로운 아자퀴놀린 유도체 |
| CA3161336A1 (en) | 2019-11-15 | 2021-05-20 | KaNDy Therapeutics Limited | New chemical process for making 6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-amine a key intermediate of nt-814 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE496032T1 (de) * | 1999-02-24 | 2011-02-15 | Hoffmann La Roche | 4-phenylpyridinderivate und deren verwendung als nk-1 rezeptorantagonisten |
| DK1157005T3 (da) | 1999-02-24 | 2005-02-14 | Hoffmann La Roche | 3-phenylpyridinderivater og anvendelsen deraf som NK-1-receptorantagonister |
| DE60006340T2 (de) | 1999-11-29 | 2004-09-09 | F. Hoffmann-La Roche Ag | 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramid |
| RS50932B (sr) | 2000-07-14 | 2010-08-31 | F. Hoffmann-La Roche Ag. | N-oksidi kao prolekovi 4-fenil-piridinskih derivata koji su antagonisti nk1 receptora |
| TWI287003B (en) | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
| TWI259180B (en) * | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
| KR100599134B1 (ko) | 2001-04-23 | 2006-07-12 | 에프. 호프만-라 로슈 아게 | 양성 전립선 비대증에 대한 ｎｋ-1 수용체 길항물질의 용도 |
| US20030083345A1 (en) | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
| US6849624B2 (en) | 2001-07-31 | 2005-02-01 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted amides |
| NZ544244A (en) * | 2003-07-03 | 2008-10-31 | Hoffmann La Roche | Dual NK1/NK3 antagonists for treating schizophrenia |
| US20060030600A1 (en) | 2004-08-06 | 2006-02-09 | Patrick Schnider | Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia |
| PL1863767T3 (pl) | 2005-03-23 | 2009-08-31 | Helsinn Healthcare Sa | Metabolity antagonistów NK-1 do leczenia wymiotów |
| JP5121716B2 (ja) | 2005-09-09 | 2013-01-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | ピリジン誘導体および精神異常の処置におけるそれらの使用 |
| DK1928427T3 (da) | 2005-09-23 | 2010-03-08 | Hoffmann La Roche | Hidtil ukendt dosisformulering |
| JP2010535769A (ja) * | 2007-08-09 | 2010-11-25 | メルク・シャープ・エンド・ドーム・コーポレイション | ピリジンカルボキサミドオレキシン受容体アンタゴニスト |
| GB0808747D0 (en) * | 2008-05-14 | 2008-06-18 | Glaxo Wellcome Mfg Pte Ltd | Novel compounds |
| WO2011054773A1 (en) * | 2009-11-03 | 2011-05-12 | Glaxosmithkline Llc | Novel lactam compounds |
| US8426450B1 (en) | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| KR20160078997A (ko) * | 2013-11-08 | 2016-07-05 | 깃세이 야쿠힌 고교 가부시키가이샤 | 카복시메틸피페리딘 유도체 |
-
2015
- 2015-05-06 TW TW104114465A patent/TWI649307B/zh active
- 2015-05-07 RU RU2016147704A patent/RU2681316C2/ru active
- 2015-05-07 DK DK15789561.6T patent/DK3141541T3/en active
- 2015-05-07 EP EP15789561.6A patent/EP3141541B1/en active Active
- 2015-05-07 JP JP2015528113A patent/JP5847362B1/ja active Active
- 2015-05-07 CN CN201580030418.XA patent/CN106414406B/zh active Active
- 2015-05-07 MX MX2016014566A patent/MX2016014566A/es active IP Right Grant
- 2015-05-07 ES ES15789561T patent/ES2704709T3/es active Active
- 2015-05-07 HU HUE15789561A patent/HUE042659T2/hu unknown
- 2015-05-07 WO PCT/JP2015/063154 patent/WO2015170693A1/ja active Application Filing
- 2015-05-07 AU AU2015257007A patent/AU2015257007B2/en active Active
- 2015-05-07 PT PT15789561T patent/PT3141541T/pt unknown
- 2015-05-07 BR BR112016025984-0A patent/BR112016025984B1/pt active IP Right Grant
- 2015-05-07 SG SG11201609298TA patent/SG11201609298TA/en unknown
- 2015-05-07 CA CA2946523A patent/CA2946523C/en active Active
- 2015-05-07 PL PL15789561T patent/PL3141541T3/pl unknown
- 2015-05-07 US US15/308,996 patent/US9708266B2/en active Active
- 2015-05-07 KR KR1020167032705A patent/KR102061544B1/ko active IP Right Grant
-
2016
- 2016-11-06 IL IL248772A patent/IL248772B/en active IP Right Grant
- 2016-11-14 ZA ZA2016/07847A patent/ZA201607847B/en unknown
-
2017
- 2017-06-22 US US15/630,238 patent/US10011568B2/en active Active
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