PL3064575T3 - Sposób różnicowania pluripotentnych komórek macierzystych indukowanych z mezenchymalnych komórek macierzystych w hepatocyt - Google Patents
Sposób różnicowania pluripotentnych komórek macierzystych indukowanych z mezenchymalnych komórek macierzystych w hepatocytInfo
- Publication number
- PL3064575T3 PL3064575T3 PL13896838T PL13896838T PL3064575T3 PL 3064575 T3 PL3064575 T3 PL 3064575T3 PL 13896838 T PL13896838 T PL 13896838T PL 13896838 T PL13896838 T PL 13896838T PL 3064575 T3 PL3064575 T3 PL 3064575T3
- Authority
- PL
- Poland
- Prior art keywords
- stem cell
- hepatocyte
- differentiating pluripotent
- induced
- mesenchymal stem
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/137—Blood-borne mesenchymal stem cells, e.g. Msc from umbilical cord blood
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1369—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from blood-borne mesenchymal stem cells, e.g. MSC from umbilical blood
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130132058A KR101542849B1 (ko) | 2013-11-01 | 2013-11-01 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 간세포로 분화시키는 방법 |
| EP13896838.3A EP3064575B1 (en) | 2013-11-01 | 2013-11-05 | Method for differentiating pluripotent stem cell induced from mesenchymal stem cell into hepatocyte |
| PCT/KR2013/009946 WO2015064802A1 (ko) | 2013-11-01 | 2013-11-05 | 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 간세포로 분화시키는 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3064575T3 true PL3064575T3 (pl) | 2020-08-10 |
Family
ID=53004390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13896838T PL3064575T3 (pl) | 2013-11-01 | 2013-11-05 | Sposób różnicowania pluripotentnych komórek macierzystych indukowanych z mezenchymalnych komórek macierzystych w hepatocyt |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10072248B2 (pl) |
| EP (1) | EP3064575B1 (pl) |
| JP (1) | JP6711757B2 (pl) |
| KR (1) | KR101542849B1 (pl) |
| CN (1) | CN105683359B (pl) |
| AU (1) | AU2013403885B2 (pl) |
| CY (1) | CY1122791T1 (pl) |
| DK (1) | DK3064575T3 (pl) |
| ES (1) | ES2776183T3 (pl) |
| HR (1) | HRP20200474T1 (pl) |
| HU (1) | HUE048804T2 (pl) |
| LT (1) | LT3064575T (pl) |
| PL (1) | PL3064575T3 (pl) |
| PT (1) | PT3064575T (pl) |
| RS (1) | RS60363B1 (pl) |
| SI (1) | SI3064575T1 (pl) |
| WO (1) | WO2015064802A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3064572T3 (da) | 2013-11-01 | 2020-05-04 | Bbhc Co Ltd | Fremgangsmåde til fremstilling af inducerede pluripotente stamceller fra mesenchymale stamceller og inducerede pluripotente stamceller produceret ved fremgangsmåden |
| KR101699761B1 (ko) * | 2014-05-23 | 2017-01-25 | 주식회사 비비에이치씨 | 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 |
| KR102018783B1 (ko) * | 2015-08-13 | 2019-09-06 | (주) 넥셀 | 간세포의 약물대사 기능 향상방법 |
| CN105385651B (zh) * | 2015-12-11 | 2019-06-14 | 湖南光琇高新生命科技有限公司 | 诱导性多能干细胞定向诱导分化为肝细胞的方法及肝细胞 |
| WO2018093233A1 (ko) | 2016-11-21 | 2018-05-24 | 성균관대학교산학협력단 | 지방줄기세포유래 엑소좀을 유효성분으로 포함하는 간 섬유증 예방 또는 치료용 조성물 |
| KR20180057546A (ko) | 2016-11-21 | 2018-05-30 | 성균관대학교산학협력단 | 지방줄기세포유래 엑소좀을 유효성분으로 포함하는 간 섬유증 예방 또는 치료용 조성물 |
| WO2020013719A1 (en) * | 2018-07-10 | 2020-01-16 | Uniwersytet Jagielloński | Stem cell culture method using plant secretion |
| WO2020122666A1 (ko) | 2018-12-14 | 2020-06-18 | 주식회사 토트사이언스 | 중간엽줄기세포가 포함된 생체 이식용 임플란트를 포함하는 간 질환의 예방 또는 치료용 약학적 조성물 |
| AU2021235252A1 (en) | 2020-03-11 | 2022-10-06 | Bit Bio Limited | Method of generating hepatic cells |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100135970A1 (en) | 2006-10-27 | 2010-06-03 | Caritas St. Elizabeth Medical Center Of Boston, In | Methods for Reprogramming Adult Somatic Cells and Uses Thereof |
| KR20100001940A (ko) | 2008-06-28 | 2010-01-06 | 최송화 | 마우스 내장용 키보드 |
| WO2010014949A2 (en) | 2008-07-31 | 2010-02-04 | The General Hospital Corporation | Compositions comprising hepatocyte-like cells and uses thereof |
| KR101016761B1 (ko) | 2009-02-26 | 2011-02-25 | 부경대학교 산학협력단 | 피부 미백활성을 갖는 감태 추출물 |
| KR101073523B1 (ko) | 2009-03-10 | 2011-10-17 | (주)나우이앤씨 | 비개착식 터널 굴착 방법 및 이에 사용되는 터널시공구조체 |
| EP2457998A4 (en) * | 2009-07-23 | 2013-08-21 | Beijing Huayuanbochuang Technology Co Ltd | METHODS FOR OBTAINING HEPATIC CELLS, HEPATIC ENDODERM CELLS, AND HEPATIC PRECURSOR CELLS BY INDUCING THE DIFFERENTIATION |
| JP2012210154A (ja) * | 2009-08-03 | 2012-11-01 | Keio Gijuku | 分化細胞由来多能性幹細胞の樹立方法 |
| WO2011037301A1 (ko) * | 2009-09-22 | 2011-03-31 | 서울대학교병원 | 성체세포로부터 만능줄기세포를 유도하는 방법 및 그 방법에 의해 제조된 만능줄기세포 |
| KR20110079436A (ko) | 2010-03-29 | 2011-07-07 | (주) 세이텍 | 오토틸트형 휴대폰 슬라이딩 힌지 |
| KR20120040488A (ko) | 2010-10-19 | 2012-04-27 | 충남대학교산학협력단 | 곰피와 감태 추출물 유래의 플로로탄닌을 포함하는 화장품 조성물 |
| KR101887956B1 (ko) | 2011-08-10 | 2018-08-13 | (주)아모레퍼시픽 | 효소 처리 감태 추출물을 포함하는 피부 미백용 조성물 |
| CN102286532B (zh) * | 2011-09-05 | 2012-10-17 | 浙江大学 | 一种获得诱导性多能干细胞的方法 |
| KR101408106B1 (ko) | 2011-12-30 | 2014-06-19 | 박영준 | 줄기세포 분화능 개선용 조성물 |
-
2013
- 2013-11-01 KR KR1020130132058A patent/KR101542849B1/ko active IP Right Grant
- 2013-11-05 LT LTEP13896838.3T patent/LT3064575T/lt unknown
- 2013-11-05 WO PCT/KR2013/009946 patent/WO2015064802A1/ko active Application Filing
- 2013-11-05 AU AU2013403885A patent/AU2013403885B2/en active Active
- 2013-11-05 JP JP2016552367A patent/JP6711757B2/ja active Active
- 2013-11-05 RS RS20200314A patent/RS60363B1/sr unknown
- 2013-11-05 PL PL13896838T patent/PL3064575T3/pl unknown
- 2013-11-05 HU HUE13896838A patent/HUE048804T2/hu unknown
- 2013-11-05 CN CN201380080667.0A patent/CN105683359B/zh active Active
- 2013-11-05 ES ES13896838T patent/ES2776183T3/es active Active
- 2013-11-05 SI SI201331690T patent/SI3064575T1/sl unknown
- 2013-11-05 EP EP13896838.3A patent/EP3064575B1/en active Active
- 2013-11-05 PT PT138968383T patent/PT3064575T/pt unknown
- 2013-11-05 US US15/033,405 patent/US10072248B2/en active Active
- 2013-11-05 DK DK13896838.3T patent/DK3064575T3/da active
-
2020
- 2020-03-16 CY CY20201100237T patent/CY1122791T1/el unknown
- 2020-03-20 HR HRP20200474TT patent/HRP20200474T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3064575A4 (en) | 2017-07-26 |
| DK3064575T3 (da) | 2020-03-16 |
| HRP20200474T1 (hr) | 2020-10-02 |
| JP2016537022A (ja) | 2016-12-01 |
| CN105683359B (zh) | 2021-08-03 |
| AU2013403885A1 (en) | 2016-06-23 |
| CY1122791T1 (el) | 2021-05-05 |
| WO2015064802A1 (ko) | 2015-05-07 |
| HUE048804T2 (hu) | 2020-09-28 |
| RS60363B1 (sr) | 2020-07-31 |
| US20160272936A1 (en) | 2016-09-22 |
| KR20150050864A (ko) | 2015-05-11 |
| CN105683359A (zh) | 2016-06-15 |
| AU2013403885B2 (en) | 2018-04-05 |
| ES2776183T3 (es) | 2020-07-29 |
| EP3064575A1 (en) | 2016-09-07 |
| US10072248B2 (en) | 2018-09-11 |
| LT3064575T (lt) | 2020-06-10 |
| SI3064575T1 (sl) | 2020-08-31 |
| EP3064575B1 (en) | 2020-02-26 |
| PT3064575T (pt) | 2020-04-02 |
| KR101542849B1 (ko) | 2015-08-10 |
| JP6711757B2 (ja) | 2020-06-17 |
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