PL299929A1 - Quinoxaline derivatives, method of obtaining sames and their use in drugs - Google Patents

Quinoxaline derivatives, method of obtaining sames and their use in drugs

Info

Publication number
PL299929A1
PL299929A1 PL92299929A PL29992992A PL299929A1 PL 299929 A1 PL299929 A1 PL 299929A1 PL 92299929 A PL92299929 A PL 92299929A PL 29992992 A PL29992992 A PL 29992992A PL 299929 A1 PL299929 A1 PL 299929A1
Authority
PL
Poland
Prior art keywords
drugs
quinoxaline derivatives
sames
obtaining
obtaining sames
Prior art date
Application number
PL92299929A
Other versions
PL171125B1 (en
Inventor
Andreas Huth
Ralph Schmiechen
Ilse Beetz
Ingrid Schumann
Lechoslaw Turski
Peter Andreas Loeschmann
David Norman Stephens
Dieter Seidelmann
Martin Krueger
Dieter Rahtz
Peter Hoelscher
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4135871A external-priority patent/DE4135871A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of PL299929A1 publication Critical patent/PL299929A1/en
Publication of PL171125B1 publication Critical patent/PL171125B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL92299929A 1991-10-26 1992-10-25 Quinoxaline derivatives, method of obtaining sames and their use in drugs PL171125B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4135871A DE4135871A1 (en) 1991-10-26 1991-10-26 New quinoxaline derivs.
DE4224200 1992-07-17
PCT/DE1992/000895 WO1993008173A1 (en) 1991-10-26 1992-10-25 Quinoxaline derivates with affinity for quisqualate-receptors

Publications (2)

Publication Number Publication Date
PL299929A1 true PL299929A1 (en) 1994-04-05
PL171125B1 PL171125B1 (en) 1997-03-28

Family

ID=25908683

Family Applications (1)

Application Number Title Priority Date Filing Date
PL92299929A PL171125B1 (en) 1991-10-26 1992-10-25 Quinoxaline derivatives, method of obtaining sames and their use in drugs

Country Status (17)

Country Link
EP (1) EP0565683A1 (en)
JP (1) JP3258008B2 (en)
KR (1) KR100262371B1 (en)
CN (1) CN1038840C (en)
AU (1) AU664212B2 (en)
CA (1) CA2099270A1 (en)
CZ (1) CZ286351B6 (en)
FI (1) FI932959A0 (en)
HU (1) HUT64756A (en)
IL (1) IL103538A (en)
NO (1) NO304693B1 (en)
NZ (1) NZ244896A (en)
PL (1) PL171125B1 (en)
PT (1) PT101004B (en)
RU (1) RU2117663C1 (en)
SK (1) SK281518B6 (en)
WO (1) WO1993008173A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK162491D0 (en) * 1991-09-20 1991-09-20 Novo Nordisk As Heterocyclic compounds, their preparation and pharmaceutical preparations containing the compounds
JP3301024B2 (en) * 1992-06-22 2002-07-15 ザ・リージェンツ・オブ・ザ・ユニバーシテイ・オブ・カリフォルニア Glycine receptor antagonist and use thereof
DE4314592A1 (en) * 1993-04-28 1994-11-03 Schering Ag Benzo (f) quinoxalinedione derivatives, their production and use in medicinal products
IL109397A0 (en) * 1993-04-28 1994-07-31 Schering Ag Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE4428152A1 (en) * 1994-06-22 1996-01-04 Basf Ag New amido-quinoxalinediones, their production and use
GB9419318D0 (en) * 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
CA2199468C (en) * 1994-09-27 2006-06-06 Jun-Ichi Shishikura 1,2,3,4-tetrahydroquinoxalinedione derivative
DE4439493A1 (en) * 1994-10-25 1996-05-02 Schering Ag New quinoxalinedione derivatives, their production and use in pharmaceuticals
DE4439492A1 (en) * 1994-10-25 1996-05-02 Schering Ag New quinoxalinedione derivatives, their production and use in pharmaceuticals
US6110911A (en) * 1995-06-07 2000-08-29 Warner-Lambert Company Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
DE19521058A1 (en) * 1995-06-09 1996-12-12 Basf Ag Process for the preparation of aromatic-containing polyether polyols
DE19545251A1 (en) * 1995-11-24 1997-05-28 Schering Ag New quinoxalinedione derivatives, their production and use in pharmaceuticals
TW448171B (en) * 1996-06-06 2001-08-01 Yamanouchi Pharma Co Ltd Imidazole-substituted quinoxalinedione derivatives
DE19624808A1 (en) 1996-06-21 1998-01-02 Basf Ag Pyrrolylquinoxalinediones, their preparation and use
DE19728326A1 (en) * 1997-06-27 1999-01-07 Schering Ag New quinoxalinedione derivatives, their production and use in pharmaceuticals
US6015800A (en) * 1997-09-03 2000-01-18 Warner-Lambert Company Substituted quinoxaline-2-ones as glutamate receptor antagonists
EP0900567A3 (en) * 1997-09-05 2001-05-02 Pfizer Products Inc. Quinazoline-4-one AMPA antagonists for the treatment of dyskinesias associated with dopamine agonist therapy
IL125950A0 (en) * 1997-09-05 1999-04-11 Pfizer Prod Inc Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
FR2769309B1 (en) 1997-10-08 2001-06-15 Oreal KERATINIC FIBER OXIDATION DYE COMPOSITION COMPRISING AN AMINO ACID DERIVATIVE AS AN OXIDATION BASE AND NOVEL AMINO ACID DERIVATIVES
GB0311406D0 (en) * 2003-05-17 2003-06-25 Queen Mary & Westfield College Substituted phosphonate fluorescent sensors,and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0118982A1 (en) * 1983-02-01 1984-09-19 Sumitomo Chemical Company, Limited Organic phosphorous quinoxalinone and their production and use
NO179551C (en) * 1987-11-10 1996-10-30 Novo Nordisk As Analogous Process for Preparing Therapeutically Effective Quinoxaline Compounds
DK69790D0 (en) * 1990-03-16 1990-03-16 Novo Nordisk As HETEROCYCLIC COMPOUNDS, THEIR PREPARATION OF USE

Also Published As

Publication number Publication date
AU664212B2 (en) 1995-11-09
NZ244896A (en) 1995-07-26
PT101004A (en) 1994-01-31
SK72793A3 (en) 1993-10-06
FI932959A (en) 1993-06-24
CA2099270A1 (en) 1993-04-27
AU2889492A (en) 1993-05-21
JP3258008B2 (en) 2002-02-18
IL103538A (en) 2001-07-24
RU2117663C1 (en) 1998-08-20
WO1993008173A1 (en) 1993-04-29
HUT64756A (en) 1994-02-28
PT101004B (en) 1999-10-29
CZ286351B6 (en) 2000-03-15
JPH06503583A (en) 1994-04-21
IL103538A0 (en) 1993-03-15
FI932959A0 (en) 1993-06-24
KR930703271A (en) 1993-11-29
CN1038840C (en) 1998-06-24
HU9301877D0 (en) 1993-09-28
KR100262371B1 (en) 2000-08-01
NO304693B1 (en) 1999-02-01
PL171125B1 (en) 1997-03-28
NO932344L (en) 1993-06-25
EP0565683A1 (en) 1993-10-20
CN1072929A (en) 1993-06-09
CZ138793A3 (en) 1994-01-19
NO932344D0 (en) 1993-06-25
SK281518B6 (en) 2001-04-09

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