NO304693B1 - Kinoxaline derivatives with affinity for quisqualate receptors - Google Patents
Kinoxaline derivatives with affinity for quisqualate receptorsInfo
- Publication number
- NO304693B1 NO304693B1 NO932116A NO932344A NO304693B1 NO 304693 B1 NO304693 B1 NO 304693B1 NO 932116 A NO932116 A NO 932116A NO 932344 A NO932344 A NO 932344A NO 304693 B1 NO304693 B1 NO 304693B1
- Authority
- NO
- Norway
- Prior art keywords
- kinoxaline
- affinity
- derivatives
- quisqualate receptors
- quisqualate
- Prior art date
Links
- 102000003678 AMPA Receptors Human genes 0.000 title 1
- 108090000078 AMPA Receptors Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4135871A DE4135871A1 (en) | 1991-10-26 | 1991-10-26 | New quinoxaline derivs. |
| DE4224200 | 1992-07-17 | ||
| PCT/DE1992/000895 WO1993008173A1 (en) | 1991-10-26 | 1992-10-25 | Quinoxaline derivates with affinity for quisqualate-receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO932344D0 NO932344D0 (en) | 1993-06-25 |
| NO932344L NO932344L (en) | 1993-06-25 |
| NO304693B1 true NO304693B1 (en) | 1999-02-01 |
Family
ID=25908683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO932116A NO304693B1 (en) | 1991-10-26 | 1993-06-25 | Kinoxaline derivatives with affinity for quisqualate receptors |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0565683A1 (en) |
| JP (1) | JP3258008B2 (en) |
| KR (1) | KR100262371B1 (en) |
| CN (1) | CN1038840C (en) |
| AU (1) | AU664212B2 (en) |
| CA (1) | CA2099270A1 (en) |
| CZ (1) | CZ286351B6 (en) |
| FI (1) | FI932959A (en) |
| HU (1) | HUT64756A (en) |
| IL (1) | IL103538A (en) |
| NO (1) | NO304693B1 (en) |
| NZ (1) | NZ244896A (en) |
| PL (1) | PL171125B1 (en) |
| PT (1) | PT101004B (en) |
| RU (1) | RU2117663C1 (en) |
| SK (1) | SK281518B6 (en) |
| WO (1) | WO1993008173A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK162491D0 (en) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocyclic compounds, their preparation and pharmaceutical preparations containing the compounds |
| ATE404201T1 (en) * | 1992-06-22 | 2008-08-15 | Univ California | GLYCINE RECEPTOR ANTAGONISTS AND THEIR USE |
| IL109397A0 (en) * | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| DE4314592A1 (en) * | 1993-04-28 | 1994-11-03 | Schering Ag | Benzo (f) quinoxalinedione derivatives, their production and use in medicinal products |
| DE4428152A1 (en) * | 1994-06-22 | 1996-01-04 | Basf Ag | New amido-quinoxalinediones, their production and use |
| GB9419318D0 (en) * | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
| EP0784054B1 (en) * | 1994-09-27 | 2001-11-28 | Yamanouchi Pharmaceutical Co. Ltd. | 1,2,3,4-tetrahydroquinoxalinedione derivatives and use as glutamate receptor antagonists |
| DE4439492A1 (en) * | 1994-10-25 | 1996-05-02 | Schering Ag | New quinoxalinedione derivatives, their production and use in pharmaceuticals |
| DE4439493A1 (en) * | 1994-10-25 | 1996-05-02 | Schering Ag | New quinoxalinedione derivatives, their production and use in pharmaceuticals |
| US6110911A (en) * | 1995-06-07 | 2000-08-29 | Warner-Lambert Company | Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
| DE19521058A1 (en) * | 1995-06-09 | 1996-12-12 | Basf Ag | Process for the preparation of aromatic-containing polyether polyols |
| DE19545251A1 (en) * | 1995-11-24 | 1997-05-28 | Schering Ag | New quinoxalinedione derivatives, their production and use in pharmaceuticals |
| TW448171B (en) * | 1996-06-06 | 2001-08-01 | Yamanouchi Pharma Co Ltd | Imidazole-substituted quinoxalinedione derivatives |
| DE19624808A1 (en) | 1996-06-21 | 1998-01-02 | Basf Ag | Pyrrolylquinoxalinediones, their preparation and use |
| DE19728326A1 (en) * | 1997-06-27 | 1999-01-07 | Schering Ag | New quinoxalinedione derivatives, their production and use in pharmaceuticals |
| US6015800A (en) * | 1997-09-03 | 2000-01-18 | Warner-Lambert Company | Substituted quinoxaline-2-ones as glutamate receptor antagonists |
| IL125950A0 (en) * | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
| EP0900567A3 (en) * | 1997-09-05 | 2001-05-02 | Pfizer Products Inc. | Quinazoline-4-one AMPA antagonists for the treatment of dyskinesias associated with dopamine agonist therapy |
| FR2769309B1 (en) | 1997-10-08 | 2001-06-15 | Oreal | KERATINIC FIBER OXIDATION DYE COMPOSITION COMPRISING AN AMINO ACID DERIVATIVE AS AN OXIDATION BASE AND NOVEL AMINO ACID DERIVATIVES |
| GB0311406D0 (en) * | 2003-05-17 | 2003-06-25 | Queen Mary & Westfield College | Substituted phosphonate fluorescent sensors,and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0118982A1 (en) * | 1983-02-01 | 1984-09-19 | Sumitomo Chemical Company, Limited | Organic phosphorous quinoxalinone and their production and use |
| NO179551C (en) * | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogous Process for Preparing Therapeutically Effective Quinoxaline Compounds |
| DK69790D0 (en) * | 1990-03-16 | 1990-03-16 | Novo Nordisk As | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION OF USE |
-
1992
- 1992-10-23 PT PT101004A patent/PT101004B/en not_active IP Right Cessation
- 1992-10-25 RU RU93044489A patent/RU2117663C1/en active
- 1992-10-25 CA CA002099270A patent/CA2099270A1/en not_active Abandoned
- 1992-10-25 SK SK727-93A patent/SK281518B6/en unknown
- 1992-10-25 IL IL10353892A patent/IL103538A/en not_active IP Right Cessation
- 1992-10-25 AU AU28894/92A patent/AU664212B2/en not_active Ceased
- 1992-10-25 CZ CZ19931387A patent/CZ286351B6/en not_active IP Right Cessation
- 1992-10-25 PL PL92299929A patent/PL171125B1/en unknown
- 1992-10-25 EP EP92922676A patent/EP0565683A1/en not_active Withdrawn
- 1992-10-25 KR KR1019930701948A patent/KR100262371B1/en not_active IP Right Cessation
- 1992-10-25 JP JP50735393A patent/JP3258008B2/en not_active Expired - Fee Related
- 1992-10-25 WO PCT/DE1992/000895 patent/WO1993008173A1/en not_active Application Discontinuation
- 1992-10-25 HU HU9301877A patent/HUT64756A/en unknown
- 1992-10-26 CN CN92113338A patent/CN1038840C/en not_active Expired - Fee Related
- 1992-10-27 NZ NZ244896A patent/NZ244896A/en unknown
-
1993
- 1993-06-24 FI FI932959A patent/FI932959A/en unknown
- 1993-06-25 NO NO932116A patent/NO304693B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL171125B1 (en) | 1997-03-28 |
| KR930703271A (en) | 1993-11-29 |
| CZ138793A3 (en) | 1994-01-19 |
| IL103538A0 (en) | 1993-03-15 |
| WO1993008173A1 (en) | 1993-04-29 |
| SK72793A3 (en) | 1993-10-06 |
| PL299929A1 (en) | 1994-04-05 |
| EP0565683A1 (en) | 1993-10-20 |
| RU2117663C1 (en) | 1998-08-20 |
| CA2099270A1 (en) | 1993-04-27 |
| PT101004A (en) | 1994-01-31 |
| JPH06503583A (en) | 1994-04-21 |
| AU664212B2 (en) | 1995-11-09 |
| PT101004B (en) | 1999-10-29 |
| NO932344D0 (en) | 1993-06-25 |
| HU9301877D0 (en) | 1993-09-28 |
| CN1038840C (en) | 1998-06-24 |
| CN1072929A (en) | 1993-06-09 |
| IL103538A (en) | 2001-07-24 |
| JP3258008B2 (en) | 2002-02-18 |
| SK281518B6 (en) | 2001-04-09 |
| NZ244896A (en) | 1995-07-26 |
| HUT64756A (en) | 1994-02-28 |
| AU2889492A (en) | 1993-05-21 |
| KR100262371B1 (en) | 2000-08-01 |
| FI932959A0 (en) | 1993-06-24 |
| NO932344L (en) | 1993-06-25 |
| FI932959A (en) | 1993-06-24 |
| CZ286351B6 (en) | 2000-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN APRIL 2003 |