PL2958893T3 - Asymetryczna synteza podstawionego pirolidyno-2-karboksyamidu - Google Patents
Asymetryczna synteza podstawionego pirolidyno-2-karboksyamiduInfo
- Publication number
- PL2958893T3 PL2958893T3 PL14706519T PL14706519T PL2958893T3 PL 2958893 T3 PL2958893 T3 PL 2958893T3 PL 14706519 T PL14706519 T PL 14706519T PL 14706519 T PL14706519 T PL 14706519T PL 2958893 T3 PL2958893 T3 PL 2958893T3
- Authority
- PL
- Poland
- Prior art keywords
- carboxamide
- asymmetric synthesis
- substituted pyrrolidine
- pyrrolidine
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767395P | 2013-02-21 | 2013-02-21 | |
| US201361909520P | 2013-11-27 | 2013-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2958893T3 true PL2958893T3 (pl) | 2017-09-29 |
Family
ID=50179579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14706519T PL2958893T3 (pl) | 2013-02-21 | 2014-02-18 | Asymetryczna synteza podstawionego pirolidyno-2-karboksyamidu |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9828340B2 (pl) |
| EP (1) | EP2958893B1 (pl) |
| JP (1) | JP6148351B2 (pl) |
| KR (1) | KR101726116B1 (pl) |
| CN (2) | CN107686459A (pl) |
| AU (1) | AU2014220865B2 (pl) |
| BR (1) | BR112015015880B1 (pl) |
| CA (1) | CA2894826C (pl) |
| DK (1) | DK2958893T3 (pl) |
| ES (1) | ES2630392T3 (pl) |
| HU (1) | HUE033534T2 (pl) |
| IL (1) | IL239888B (pl) |
| MX (1) | MX365948B (pl) |
| PL (1) | PL2958893T3 (pl) |
| RU (1) | RU2015133939A (pl) |
| SG (1) | SG11201505150TA (pl) |
| SI (1) | SI2958893T1 (pl) |
| WO (1) | WO2014128094A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10227298B2 (en) | 2014-04-15 | 2019-03-12 | Hoffmann-La Roche Inc. | Solid forms of a pharmaceutically active compound |
| GB201919219D0 (en) | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| KR20230058124A (ko) | 2020-08-27 | 2023-05-02 | 오츠카 세이야쿠 가부시키가이샤 | Mdm2 길항제를 사용하는 암 치료를 위한 생체표지자 |
| GB202103080D0 (en) | 2021-03-04 | 2021-04-21 | Otsuka Pharma Co Ltd | Cancer biomarkers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8354444B2 (en) * | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
| US20120010235A1 (en) * | 2010-07-12 | 2012-01-12 | Xin-Jie Chu | N-substituted pyrrolidines |
| US20120046306A1 (en) | 2010-08-18 | 2012-02-23 | David Joseph Bartkovitz | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists |
| US20120065210A1 (en) * | 2010-09-15 | 2012-03-15 | Xin-Jie Chu | Substituted hexahydropyrrolo[1,2-c]imidazolones |
-
2014
- 2014-02-18 AU AU2014220865A patent/AU2014220865B2/en active Active
- 2014-02-18 HU HUE14706519A patent/HUE033534T2/en unknown
- 2014-02-18 WO PCT/EP2014/053057 patent/WO2014128094A1/en not_active Ceased
- 2014-02-18 CN CN201710951225.9A patent/CN107686459A/zh active Pending
- 2014-02-18 JP JP2015558415A patent/JP6148351B2/ja active Active
- 2014-02-18 EP EP14706519.7A patent/EP2958893B1/en active Active
- 2014-02-18 CA CA2894826A patent/CA2894826C/en active Active
- 2014-02-18 PL PL14706519T patent/PL2958893T3/pl unknown
- 2014-02-18 RU RU2015133939A patent/RU2015133939A/ru not_active Application Discontinuation
- 2014-02-18 CN CN201480009671.2A patent/CN105026370B/zh active Active
- 2014-02-18 BR BR112015015880-3A patent/BR112015015880B1/pt active IP Right Grant
- 2014-02-18 DK DK14706519.7T patent/DK2958893T3/en active
- 2014-02-18 SG SG11201505150TA patent/SG11201505150TA/en unknown
- 2014-02-18 ES ES14706519.7T patent/ES2630392T3/es active Active
- 2014-02-18 US US14/766,049 patent/US9828340B2/en active Active
- 2014-02-18 MX MX2015010561A patent/MX365948B/es active IP Right Grant
- 2014-02-18 KR KR1020157022501A patent/KR101726116B1/ko active Active
- 2014-02-18 SI SI201430263T patent/SI2958893T1/sl unknown
-
2015
- 2015-07-09 IL IL239888A patent/IL239888B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015015880A2 (pt) | 2017-07-11 |
| CA2894826A1 (en) | 2014-08-28 |
| CA2894826C (en) | 2021-03-23 |
| DK2958893T3 (en) | 2017-07-10 |
| US20160002158A1 (en) | 2016-01-07 |
| CN107686459A (zh) | 2018-02-13 |
| JP2016509037A (ja) | 2016-03-24 |
| KR20150109439A (ko) | 2015-10-01 |
| CN105026370A (zh) | 2015-11-04 |
| MX2015010561A (es) | 2015-11-16 |
| AU2014220865A8 (en) | 2015-08-20 |
| KR101726116B1 (ko) | 2017-04-11 |
| CN105026370B (zh) | 2017-11-10 |
| BR112015015880B1 (pt) | 2022-07-19 |
| WO2014128094A1 (en) | 2014-08-28 |
| HUE033534T2 (en) | 2017-12-28 |
| ES2630392T3 (es) | 2017-08-21 |
| RU2015133939A (ru) | 2017-03-27 |
| IL239888B (en) | 2018-11-29 |
| JP6148351B2 (ja) | 2017-06-14 |
| US9828340B2 (en) | 2017-11-28 |
| IL239888A0 (en) | 2015-08-31 |
| AU2014220865B2 (en) | 2017-03-30 |
| MX365948B (es) | 2019-06-19 |
| EP2958893A1 (en) | 2015-12-30 |
| SG11201505150TA (en) | 2015-09-29 |
| EP2958893B1 (en) | 2017-05-03 |
| HK1211294A1 (en) | 2016-05-20 |
| SI2958893T1 (sl) | 2017-08-31 |
| AU2014220865A1 (en) | 2015-07-02 |
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