PL2978750T3 - Synteza Dabigatranu - Google Patents
Synteza DabigatranuInfo
- Publication number
- PL2978750T3 PL2978750T3 PL14736463T PL14736463T PL2978750T3 PL 2978750 T3 PL2978750 T3 PL 2978750T3 PL 14736463 T PL14736463 T PL 14736463T PL 14736463 T PL14736463 T PL 14736463T PL 2978750 T3 PL2978750 T3 PL 2978750T3
- Authority
- PL
- Poland
- Prior art keywords
- dabigatran
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1957MU2013 | 2013-06-06 | ||
EP14736463.2A EP2978750B1 (en) | 2013-03-25 | 2014-03-25 | "synthesis of dabigatran" |
PCT/IN2014/000188 WO2014167577A2 (en) | 2013-03-25 | 2014-03-25 | "synthesis of dabigatran" |
IN1117MU2013 IN2013MU01117A (pl) | 2013-03-25 | 2014-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2978750T3 true PL2978750T3 (pl) | 2020-07-13 |
Family
ID=51136539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL14736463T PL2978750T3 (pl) | 2013-03-25 | 2014-03-25 | Synteza Dabigatranu |
Country Status (6)
Country | Link |
---|---|
US (1) | US9688657B2 (pl) |
EP (1) | EP2978750B1 (pl) |
CA (1) | CA2907839C (pl) |
ES (1) | ES2791187T3 (pl) |
PL (1) | PL2978750T3 (pl) |
WO (1) | WO2014167577A2 (pl) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107365299B (zh) * | 2017-03-09 | 2020-04-21 | 罗欣药业(上海)有限公司 | 一种达比加群酯的制备方法及其中间体 |
CN109125274A (zh) * | 2017-06-28 | 2019-01-04 | 上海美悦生物科技发展有限公司 | 注射用苯并咪唑类药用酸组合物及其制备方法和用途 |
CN108373465B (zh) * | 2018-04-13 | 2020-04-07 | 成都倍特药业股份有限公司 | 一种达比加群酯杂质及其制备、检测方法 |
CN108997316A (zh) * | 2018-08-17 | 2018-12-14 | 四川青木制药有限公司 | 一种达比加群酯的制备工艺 |
CN111253369A (zh) * | 2018-11-30 | 2020-06-09 | 上海医药集团股份有限公司 | 一种苯磺酸盐、其制备方法及其在制备达比加群酯中的应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4322431A (en) * | 1979-02-09 | 1982-03-30 | Ciba-Geigy Corporation | Pharmaceutical preparations containing benzimidazole 2-derivatives |
US8399678B2 (en) * | 2009-11-18 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dabigatran etexilate |
CN103025715A (zh) | 2010-07-09 | 2013-04-03 | 埃斯特维化学股份有限公司 | 用于制备凝血酶特异性抑制剂的中间体和方法 |
EP2649060B1 (en) * | 2010-12-06 | 2017-04-05 | MSN Laboratories Limited | Process for the preparation of benzimidazole derivatives and its salts |
CN102633713B (zh) * | 2012-03-22 | 2013-12-11 | 南京工业大学 | 达比加群酯中间体及其制备方法、以及制备达比加群酯的方法 |
CN102850326B (zh) * | 2012-06-19 | 2014-04-09 | 上海现代制药股份有限公司 | 一种达比加群酯中间体及其制备方法和应用 |
CN102850327B (zh) * | 2012-06-19 | 2014-07-16 | 上海现代制药股份有限公司 | 一种制备达比加群酯的中间体及其制备方法和应用 |
CN104418839B (zh) * | 2013-08-26 | 2019-02-01 | 深圳翰宇药业股份有限公司 | 达比加群酯的合成方法 |
-
2014
- 2014-03-25 US US14/779,911 patent/US9688657B2/en active Active
- 2014-03-25 ES ES14736463T patent/ES2791187T3/es active Active
- 2014-03-25 WO PCT/IN2014/000188 patent/WO2014167577A2/en active Application Filing
- 2014-03-25 CA CA2907839A patent/CA2907839C/en active Active
- 2014-03-25 EP EP14736463.2A patent/EP2978750B1/en active Active
- 2014-03-25 PL PL14736463T patent/PL2978750T3/pl unknown
Also Published As
Publication number | Publication date |
---|---|
WO2014167577A3 (en) | 2015-03-26 |
US20160060248A1 (en) | 2016-03-03 |
ES2791187T3 (es) | 2020-11-03 |
WO2014167577A2 (en) | 2014-10-16 |
EP2978750A2 (en) | 2016-02-03 |
CA2907839A1 (en) | 2014-10-16 |
CA2907839C (en) | 2021-11-23 |
US9688657B2 (en) | 2017-06-27 |
EP2978750B1 (en) | 2020-03-04 |
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