PL2820001T3 - Sodowe i wapniowe sole pochodniej dihydrochinazoliny i ich zastosowanie jako środków przeciwwirusowych - Google Patents
Sodowe i wapniowe sole pochodniej dihydrochinazoliny i ich zastosowanie jako środków przeciwwirusowychInfo
- Publication number
- PL2820001T3 PL2820001T3 PL13709804.2T PL13709804T PL2820001T3 PL 2820001 T3 PL2820001 T3 PL 2820001T3 PL 13709804 T PL13709804 T PL 13709804T PL 2820001 T3 PL2820001 T3 PL 2820001T3
- Authority
- PL
- Poland
- Prior art keywords
- dihydroquinazoline
- derivate
- sodium
- calcium salts
- antiviral agents
- Prior art date
Links
- NTURVSFTOYPGON-UHFFFAOYSA-N Dihydroquinazoline Chemical compound C1=CC=C2C=NCNC2=C1 NTURVSFTOYPGON-UHFFFAOYSA-N 0.000 title 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
- 239000003443 antiviral agent Substances 0.000 title 1
- 159000000007 calcium salts Chemical class 0.000 title 1
- 239000011734 sodium Substances 0.000 title 1
- 229910052708 sodium Inorganic materials 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012101659A DE102012101659A1 (de) | 2012-02-29 | 2012-02-29 | Salze eines Dihydrochinazolinderivats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2820001T3 true PL2820001T3 (pl) | 2016-12-30 |
Family
ID=47891621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13709804.2T PL2820001T3 (pl) | 2012-02-29 | 2013-02-28 | Sodowe i wapniowe sole pochodniej dihydrochinazoliny i ich zastosowanie jako środków przeciwwirusowych |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9637459B2 (pl) |
| EP (1) | EP2820001B1 (pl) |
| JP (1) | JP6235494B2 (pl) |
| CN (1) | CN104144917B (pl) |
| CA (1) | CA2865049C (pl) |
| CY (1) | CY1117796T1 (pl) |
| DE (1) | DE102012101659A1 (pl) |
| DK (1) | DK2820001T3 (pl) |
| ES (1) | ES2583362T3 (pl) |
| HR (1) | HRP20160813T1 (pl) |
| HU (1) | HUE027750T2 (pl) |
| LT (1) | LT2820001T (pl) |
| PL (1) | PL2820001T3 (pl) |
| PT (1) | PT2820001T (pl) |
| RS (1) | RS54990B1 (pl) |
| SI (1) | SI2820001T1 (pl) |
| SM (1) | SMT201600344B (pl) |
| WO (1) | WO2013127971A1 (pl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10319612A1 (de) * | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| DE102012101673A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| MX373764B (es) * | 2013-06-19 | 2020-03-24 | Aic246 Ag & Co Kg | Letermovir amorfo y formulaciones farmaceuticas solidas del mismo para administracion por via oral. |
| WO2016109360A1 (en) * | 2014-12-29 | 2016-07-07 | Auspex Pharmaceuticals, Inc. | Dihydroquinazoline inhibitors of viral terminase |
| HRP20221112T1 (hr) | 2015-07-22 | 2022-11-25 | Enanta Pharmaceuticals, Inc. | Derivati benzodiazepina kao inhibitori rsv |
| CN111741960B (zh) * | 2018-02-08 | 2021-06-25 | 南京明德新药研发有限公司 | 一种3,4-二氢噻吩并[3,2-d]嘧啶类化合物的晶型及其制备方法 |
| AU2020240024B2 (en) | 2019-03-18 | 2025-06-26 | Enanta Pharmaceuticals, Inc | Benzodiazepine derivatives as RSV inhibitors |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| AR121437A1 (es) * | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acético |
| AR121439A1 (es) * | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato |
| UY39099A (es) * | 2020-02-27 | 2021-08-31 | Aic246 Gmbh & Co Kg | 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo |
| AR121440A1 (es) | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales |
| AR121438A1 (es) * | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio |
| US11534439B2 (en) | 2020-07-07 | 2022-12-27 | Enanta Pharmaceuticals, Inc. | Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors |
| IT202000017617A1 (it) | 2020-07-21 | 2022-01-21 | Olon Spa | Procedimento per la preparazione di un intermedio utilizzato nella sintesi del letermovir |
| CA3189271A1 (en) * | 2020-08-17 | 2022-02-24 | Girij Pal Singh | A precipitation process for amorphous letermovir |
| US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| MX2023009961A (es) | 2021-02-26 | 2023-09-05 | Enanta Pharm Inc | Compuestos heterociclicos antivirales. |
| CN115403528B (zh) * | 2021-05-27 | 2025-01-07 | 南京正大天晴制药有限公司 | 无定形3,4-二氢喹唑啉衍生物的制备方法 |
| CN114031560B (zh) * | 2021-11-16 | 2022-10-04 | 山东诚创蓝海医药科技有限公司 | 一种来特莫韦钠盐的制备方法 |
| AR128035A1 (es) | 2021-12-21 | 2024-03-20 | Aic246 Ag & Co Kg | Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| US12162857B2 (en) | 2022-04-27 | 2024-12-10 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| CN117229223A (zh) * | 2022-06-08 | 2023-12-15 | 苏州远智医药科技有限公司 | 一种杂环衍生物及其药物组合物、应用 |
| TW202535393A (zh) | 2023-12-21 | 2025-09-16 | 德商Ａｉｃ246股份兩合公司 | 2-[(4r,s)-8-氟-2-[4-(3-甲氧基苯基)哌嗪-1-基]-3-[2-甲氧基-5-(三氟甲基)苯基]-3,4-二氫喹唑啉-4-基]乙酸之非鏡像異構物胺基醇鹽及胺基醚鹽及其於鏡像異構物分離之用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10319612A1 (de) | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| DE102005027517A1 (de) | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Verfahren zur Herstellung von Dihydrochinazolinen |
| DE102012101673A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
-
2012
- 2012-02-29 DE DE102012101659A patent/DE102012101659A1/de not_active Ceased
-
2013
- 2013-02-28 HU HUE13709804A patent/HUE027750T2/en unknown
- 2013-02-28 CA CA2865049A patent/CA2865049C/en active Active
- 2013-02-28 JP JP2014559234A patent/JP6235494B2/ja active Active
- 2013-02-28 PT PT137098042T patent/PT2820001T/pt unknown
- 2013-02-28 HR HRP20160813TT patent/HRP20160813T1/hr unknown
- 2013-02-28 ES ES13709804.2T patent/ES2583362T3/es active Active
- 2013-02-28 RS RS20160575A patent/RS54990B1/sr unknown
- 2013-02-28 SI SI201330241A patent/SI2820001T1/sl unknown
- 2013-02-28 EP EP13709804.2A patent/EP2820001B1/de active Active
- 2013-02-28 PL PL13709804.2T patent/PL2820001T3/pl unknown
- 2013-02-28 LT LTEP13709804.2T patent/LT2820001T/lt unknown
- 2013-02-28 WO PCT/EP2013/054115 patent/WO2013127971A1/de not_active Ceased
- 2013-02-28 DK DK13709804.2T patent/DK2820001T3/en active
- 2013-02-28 US US14/381,618 patent/US9637459B2/en active Active
- 2013-02-28 CN CN201380011794.5A patent/CN104144917B/zh active Active
-
2016
- 2016-07-18 CY CY20161100698T patent/CY1117796T1/el unknown
- 2016-09-30 SM SM201600344T patent/SMT201600344B/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2583362T3 (es) | 2016-09-20 |
| EP2820001B1 (de) | 2016-04-20 |
| JP2015508802A (ja) | 2015-03-23 |
| CN104144917A (zh) | 2014-11-12 |
| HRP20160813T1 (hr) | 2016-09-23 |
| SI2820001T1 (sl) | 2016-08-31 |
| EP2820001A1 (de) | 2015-01-07 |
| LT2820001T (lt) | 2016-11-10 |
| CA2865049A1 (en) | 2013-09-06 |
| DK2820001T3 (en) | 2016-08-01 |
| US9637459B2 (en) | 2017-05-02 |
| DE102012101659A1 (de) | 2013-08-29 |
| CA2865049C (en) | 2018-11-13 |
| CN104144917B (zh) | 2017-06-20 |
| RS54990B1 (sr) | 2016-11-30 |
| SMT201600344B (it) | 2016-11-10 |
| JP6235494B2 (ja) | 2017-11-22 |
| US20150038514A1 (en) | 2015-02-05 |
| WO2013127971A1 (de) | 2013-09-06 |
| CY1117796T1 (el) | 2017-05-17 |
| HUE027750T2 (en) | 2016-10-28 |
| HK1205509A1 (zh) | 2015-12-18 |
| PT2820001T (pt) | 2016-07-15 |
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