PL2807171T3 - Związki heterocykliczne i sposoby ich stosowania - Google Patents

Związki heterocykliczne i sposoby ich stosowania

Info

Publication number
PL2807171T3
PL2807171T3 PL13741412T PL13741412T PL2807171T3 PL 2807171 T3 PL2807171 T3 PL 2807171T3 PL 13741412 T PL13741412 T PL 13741412T PL 13741412 T PL13741412 T PL 13741412T PL 2807171 T3 PL2807171 T3 PL 2807171T3
Authority
PL
Poland
Prior art keywords
methods
heterocyclic compounds
heterocyclic
compounds
Prior art date
Application number
PL13741412T
Other languages
English (en)
Inventor
Thomas David Mccarthy
Alan Naylor
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2012900285A external-priority patent/AU2012900285A0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL2807171T3 publication Critical patent/PL2807171T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/056Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
PL13741412T 2012-01-25 2013-01-25 Związki heterocykliczne i sposoby ich stosowania PL2807171T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2012900285A AU2012900285A0 (en) 2012-01-25 Methods of treatment or prophylaxis
EP13741412.4A EP2807171B1 (en) 2012-01-25 2013-01-25 Heterocyclic compounds and methods for their use
PCT/AU2013/000062 WO2013110135A1 (en) 2012-01-25 2013-01-25 Heterocyclic compounds and methods for their use

Publications (1)

Publication Number Publication Date
PL2807171T3 true PL2807171T3 (pl) 2021-01-25

Family

ID=48872833

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13741412T PL2807171T3 (pl) 2012-01-25 2013-01-25 Związki heterocykliczne i sposoby ich stosowania

Country Status (12)

Country Link
US (1) US9624234B2 (pl)
EP (1) EP2807171B1 (pl)
JP (1) JP6073926B2 (pl)
CN (1) CN104470930B (pl)
AU (1) AU2013202978B2 (pl)
CA (1) CA2861233C (pl)
ES (1) ES2830023T3 (pl)
NZ (1) NZ627558A (pl)
PL (1) PL2807171T3 (pl)
PT (1) PT2807171T (pl)
WO (1) WO2013110135A1 (pl)
ZA (1) ZA201405257B (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6232384B2 (ja) 2012-01-06 2017-11-15 ノバルティス アーゲー 複素環式化合物およびその使用方法
CN104470903B (zh) 2012-01-25 2017-02-22 诺华股份有限公司 杂环化合物和它们的使用方法
JP6505682B2 (ja) 2013-07-08 2019-04-24 ノバルティス アーゲー ヘテロ環式化合物およびそれらの使用方法
WO2016113668A1 (en) 2015-01-13 2016-07-21 Novartis Ag Pyrrolidine derivatives as angiotensin ii type 2 antagonists
US10308628B2 (en) 2015-03-12 2019-06-04 Novartis Ag Heterocyclic compounds and methods for their use
CN105021735B (zh) * 2015-07-21 2017-09-19 中国科学院西北高原生物研究所 白刺种子或其提取物中ss和rsMTCA的检测方法
US9650338B1 (en) 2016-07-29 2017-05-16 VDM Biochemicals, Inc. Opioid antagonist compounds and methods of making and using
EP4684865A3 (en) 2017-04-18 2026-03-18 Nouvel Technologies Inc. Sulfur production
WO2019040105A2 (en) * 2017-08-21 2019-02-28 Acadia Pharmaceuticals Inc. COMPOUNDS, SALTS THEREOF AND METHODS FOR THE TREATMENT OF DISEASES
CN117645606A (zh) 2018-03-23 2024-03-05 北京泰德制药股份有限公司 受体抑制剂、包含其的药物组合物及其用途
WO2019242599A1 (zh) * 2018-06-19 2019-12-26 浙江海正药业股份有限公司 四氢异喹啉类衍生物、其制备方法及其用途
CN114206443B (zh) 2019-05-10 2024-02-09 浙江海正药业股份有限公司 芳环或杂芳环类衍生物及其制备方法和用途
CN110128393B (zh) * 2019-06-21 2022-09-30 华侨大学 一种取代异香豆素衍生物的制备方法
CN113880825B (zh) 2020-07-01 2025-03-14 浙江海正药业股份有限公司 四氢异喹啉类衍生物的盐、其制备方法及其医药应用

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
DE3063420D1 (en) * 1979-03-26 1983-07-07 Takeda Chemical Industries Ltd Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
FR2470767A1 (fr) 1979-12-07 1981-06-12 Science Union & Cie Nouveaux iminoacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzymes
FR2487829A2 (fr) 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3134933A1 (de) 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
DE3302126A1 (de) 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
JPS6216466A (ja) 1985-07-16 1987-01-24 Iwaki Seiyaku Kk テトラヒドロピリジン誘導体
US5612360A (en) 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US5236934A (en) * 1992-08-26 1993-08-17 E. I. Du Pont De Nemours And Company 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
US5610165A (en) * 1994-02-17 1997-03-11 Merck & Co., Inc. N-acylpiperidine tachykinin antagonists
JPH0892207A (ja) 1994-07-26 1996-04-09 Sankyo Co Ltd ピロリジン誘導体
BE1012622A3 (fr) 1999-04-21 2001-01-09 Solvay Procede pour la separation d'enantiomeres et reactif enantiopur.
CA2566094A1 (en) 2004-05-26 2005-12-08 Eisai R & D Management Co., Ltd. Cinnamide compound
JP4827821B2 (ja) 2004-05-26 2011-11-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物
WO2006055951A2 (en) * 2004-11-19 2006-05-26 Portola Pharmaceuticals, Inc. Tetrahydroisoquinolines as factor xa inhibitors
CN102861019B (zh) 2004-12-24 2016-05-25 诺华股份有限公司 治疗或预防神经性疼痛的药物
EP2952185A1 (en) 2006-03-20 2015-12-09 Spinifex Pharmaceuticals Pty Ltd Method of treatment or prophylaxis of inflammatory pain
US9095587B2 (en) 2010-01-19 2015-08-04 Spinifex Pharmaceuticals Pty Ltd Methods and compositions for improved nerve conduction velocity

Also Published As

Publication number Publication date
CA2861233C (en) 2021-05-04
NZ627558A (en) 2016-07-29
HK1201531A1 (en) 2015-09-04
EP2807171B1 (en) 2020-08-12
CN104470930B (zh) 2017-02-22
CA2861233A1 (en) 2013-08-01
EP2807171A4 (en) 2015-10-21
AU2013202978B2 (en) 2016-05-19
WO2013110135A1 (en) 2013-08-01
EP2807171A1 (en) 2014-12-03
PT2807171T (pt) 2020-11-03
CN104470930A (zh) 2015-03-25
JP6073926B2 (ja) 2017-02-01
US9624234B2 (en) 2017-04-18
ES2830023T3 (es) 2021-06-02
ZA201405257B (en) 2016-10-26
JP2015504901A (ja) 2015-02-16
US20150218180A1 (en) 2015-08-06

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