PL2736600T3 - Mikropęcherzyki wyizolowane z mezenchymalnych komórek macierzystych do zastosowania jako środki immunosupresyjne - Google Patents

Mikropęcherzyki wyizolowane z mezenchymalnych komórek macierzystych do zastosowania jako środki immunosupresyjne

Info

Publication number
PL2736600T3
PL2736600T3 PL12773379T PL12773379T PL2736600T3 PL 2736600 T3 PL2736600 T3 PL 2736600T3 PL 12773379 T PL12773379 T PL 12773379T PL 12773379 T PL12773379 T PL 12773379T PL 2736600 T3 PL2736600 T3 PL 2736600T3
Authority
PL
Poland
Prior art keywords
stem cells
mesenchymal stem
immunosuppressive agents
microvesicles isolated
microvesicles
Prior art date
Application number
PL12773379T
Other languages
English (en)
Inventor
Maurizio Muraca
Alessandra Fierabracci
Original Assignee
Cryo-Save Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44675724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2736600(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cryo-Save Ag filed Critical Cryo-Save Ag
Publication of PL2736600T3 publication Critical patent/PL2736600T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PL12773379T 2011-07-28 2012-07-26 Mikropęcherzyki wyizolowane z mezenchymalnych komórek macierzystych do zastosowania jako środki immunosupresyjne PL2736600T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000403A ITRM20110403A1 (it) 2011-07-28 2011-07-28 Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
EP12773379.8A EP2736600B1 (en) 2011-07-28 2012-07-26 Microvesicles isolated from mesenchymal stem cells for use as immunosuppressive agents

Publications (1)

Publication Number Publication Date
PL2736600T3 true PL2736600T3 (pl) 2017-04-28

Family

ID=44675724

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12773379T PL2736600T3 (pl) 2011-07-28 2012-07-26 Mikropęcherzyki wyizolowane z mezenchymalnych komórek macierzystych do zastosowania jako środki immunosupresyjne

Country Status (12)

Country Link
US (2) US20140220053A1 (pl)
EP (1) EP2736600B1 (pl)
CN (1) CN103917275B (pl)
AU (2) AU2012288431A1 (pl)
CA (1) CA2842296C (pl)
DK (1) DK2736600T3 (pl)
ES (1) ES2604946T3 (pl)
HU (1) HUE029784T2 (pl)
IT (1) ITRM20110403A1 (pl)
PL (1) PL2736600T3 (pl)
PT (1) PT2736600T (pl)
WO (1) WO2013014691A1 (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105209881B (zh) * 2013-03-13 2021-01-22 迈阿密大学 从细胞培养上清液和生物流体分离并纯化微泡的方法
EP3003290B1 (en) 2013-06-05 2021-03-10 AgeX Therapeutics, Inc. Compositions for use in the treatment of wounds in mammalian species
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
CN104490931B (zh) * 2014-12-17 2018-08-21 江苏大学 人脐带间质干细胞分泌的exosome治疗皮肤损伤的应用
JP2018536438A (ja) 2015-12-07 2018-12-13 バイオタイム，インコーポレーテッド 多様な多能性幹細胞から誘導された褐色脂肪細胞の再誘導のための方法
CA3019574C (en) * 2016-03-31 2025-09-23 Sanbio Inc Medium, methods, cells and secreted factors for stem cell culture and therapy
US20190255115A1 (en) * 2016-05-25 2019-08-22 Erasmus University Medical Center Rotterdam Use of mesenchymal stem cells and parts thereof
WO2019040896A1 (en) * 2017-08-24 2019-02-28 The Texas A&M University System EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STEM CELLS / MESENCHYMAL STROMAL CELLS, AND USES THEREOF IN AUTOIMMUNE DISEASES
CN111527199A (zh) * 2017-11-16 2020-08-11 得克萨斯大学体系董事会 用于制备来源于msc的外泌体的方法
US20210161967A1 (en) * 2017-12-06 2021-06-03 Fondazione Irccs "Ca' Granda - Ospedale Maggiore Policlinico" Extracellular vesicles and uses thereof
WO2019111198A1 (en) 2017-12-06 2019-06-13 Fondazione Irccs "Ca' Granda - Ospedale Maggiore Policlinico" Extracellular vesicles and uses thereof
EP3755349A4 (en) 2018-02-21 2021-11-17 Board of Regents, The University of Texas System PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
ES2724215B2 (es) * 2018-03-01 2020-04-14 Univ Alcala Henares Microvesículas endoteliales con efecto microbicida
JP7474702B2 (ja) 2018-03-28 2024-04-25 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム エキソソームから単離されたｄｎａにおけるエピジェネティック変化の同定法
US12453743B2 (en) 2018-05-30 2025-10-28 Direct Biologics, Llc Mesenchymal stem cell (MSC) growth factor and extracellular vesicle preparation in frozen or powdered form and methods of use
CN108542917A (zh) * 2018-07-20 2018-09-18 深圳市第二人民医院 一种带有人关节液间充质干细胞外泌体提取物的风湿骨痛疾病治疗注射剂及其制备方法
CN109498541A (zh) * 2018-12-12 2019-03-22 福建省海西细胞生物工程有限公司 一种智能改善多种皮肤问题的干细胞微囊组合物
MX2021010739A (es) * 2019-03-12 2021-12-15 Boehringer Ingelheim Veterinary Medicine Belgium Celulas madre mesenquimales inmunomoduladoras.
CA3138177A1 (en) * 2019-04-29 2020-11-05 Direct Biologics Llc Method for the treatment of periodontal disease using characterized mesenchymal stem cell growth factors and exosomes
CN110179826B (zh) * 2019-05-29 2021-08-31 武汉五州润达生物医药科技有限公司 人脐带间充质干细胞来源干细胞因子微囊泡制剂及制备方法
EP3999083A4 (en) 2019-07-18 2023-07-26 Direct Biologics LLC Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
CN110755450B (zh) * 2019-11-12 2020-06-30 山东大学齐鲁医院 间充质干细胞来源的细胞外囊泡在治疗蛛网膜下腔出血中的应用
EP3909594A1 (en) * 2020-05-14 2021-11-17 Bernat Soria Escoms Mesenchymal stromal cells for the treatment of covid-19 and other inflammatory, autoimmune and degenerative diseases
CN112300984A (zh) * 2020-09-21 2021-02-02 四川大学华西医院 一种医用hUC-MSCs-MVs批量制备流程及质控

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789734A (en) * 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
US20020004041A1 (en) 1999-02-19 2002-01-10 Albert Matthew L. Methods for abrogating a cellular immune response
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
IL160142A0 (en) 2001-08-17 2004-06-20 Anosys Inc Methods and compounds for the targeting of protein to exosomes
US7914792B2 (en) 2003-02-14 2011-03-29 Exothera L.L.C. Methods and compounds for raising antibodies and for screening antibody repertoires
US8021847B2 (en) * 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
KR20070058441A (ko) 2004-07-01 2007-06-08 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 면역억제성 엑소솜
JP5719171B2 (ja) 2007-10-15 2015-05-13 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 内皮細胞移植、特に膵島移植による糖尿病の処置におけるアジュバント活性を有する医薬を調製するための微小胞（ｍｖ）の使用、および関連方法
US20110003008A1 (en) * 2008-02-22 2011-01-06 Agency For Science, Technology And Research (A*Star) Mesenchymal stem cell particles
EP2294196A1 (en) * 2008-06-06 2011-03-16 Centre National de la Recherche Scientifique - CNRS Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
US20120107413A1 (en) 2009-07-23 2012-05-03 Singapore Health Services Pte Ltd Pre-natal mesenchymal stem cells
US20120219632A1 (en) 2009-11-02 2012-08-30 Agency For Science, Technology And Research Methods for monitoring cellular states and for immortalizing mesenchymal stem cell
EP2363136A1 (en) * 2010-03-02 2011-09-07 Fresenius Medical Care Deutschland GmbH Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease
JP5911874B2 (ja) * 2010-10-18 2016-04-27 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 発毛を促進又は増強するためのエキソソームの使用
US20140004601A1 (en) * 2010-12-20 2014-01-02 Agency For Science, Technology And Research Method of purifying exosomes
CN109432126B (zh) * 2011-03-11 2022-06-14 儿童医学中心公司 与间充质干细胞外来体相关的方法和组合物

Also Published As

Publication number Publication date
AU2017204319A1 (en) 2017-07-20
US20180140642A1 (en) 2018-05-24
DK2736600T3 (en) 2016-12-12
US20140220053A1 (en) 2014-08-07
AU2012288431A1 (en) 2014-02-06
CN103917275B (zh) 2017-09-08
CA2842296A1 (en) 2013-01-31
EP2736600A1 (en) 2014-06-04
EP2736600B1 (en) 2016-08-31
ITRM20110403A1 (it) 2013-01-29
ES2604946T3 (es) 2017-03-10
CN103917275A (zh) 2014-07-09
HUE029784T2 (en) 2017-04-28
PT2736600T (pt) 2016-11-28
CA2842296C (en) 2018-09-04
WO2013014691A1 (en) 2013-01-31

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