PL2654758T3 - Kompozycja zawierająca co najmniej dwa związki, która indukuje 2,3-dioksygenazę indolaminy (IDO) do leczenia zaburzenia autoimmunologicznego lub immunologicznego odrzucenia narządów - Google Patents

Kompozycja zawierająca co najmniej dwa związki, która indukuje 2,3-dioksygenazę indolaminy (IDO) do leczenia zaburzenia autoimmunologicznego lub immunologicznego odrzucenia narządów

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Publication number
PL2654758T3
PL2654758T3 PL11850142T PL11850142T PL2654758T3 PL 2654758 T3 PL2654758 T3 PL 2654758T3 PL 11850142 T PL11850142 T PL 11850142T PL 11850142 T PL11850142 T PL 11850142T PL 2654758 T3 PL2654758 T3 PL 2654758T3
Authority
PL
Poland
Prior art keywords
ido
dioxygenase
organs
compounds
treatment
Prior art date
Application number
PL11850142T
Other languages
English (en)
Polish (pl)
Inventor
Leif Salford
Hans Olov Sjögren
Bengt Widegren
Original Assignee
Idogen Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idogen Ab filed Critical Idogen Ab
Publication of PL2654758T3 publication Critical patent/PL2654758T3/pl

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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
PL11850142T 2010-12-22 2011-12-20 Kompozycja zawierająca co najmniej dwa związki, która indukuje 2,3-dioksygenazę indolaminy (IDO) do leczenia zaburzenia autoimmunologicznego lub immunologicznego odrzucenia narządów PL2654758T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1051356 2010-12-22
EP11850142.8A EP2654758B1 (en) 2010-12-22 2011-12-20 A composition comprising at least two compounds which induces indolamine 2,3-dioxygenase (ido), for the treatment of an autoimmune disorder or immune rejection of organs
PCT/SE2011/051544 WO2012087234A1 (en) 2010-12-22 2011-12-20 A composition comprising at least to compounds which induces indolamine 2,3-dioxygenase (ido), for the treatment of an autoimmune disorder or suffering from immune rejection of organs

Publications (1)

Publication Number Publication Date
PL2654758T3 true PL2654758T3 (pl) 2017-10-31

Family

ID=46314247

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11850142T PL2654758T3 (pl) 2010-12-22 2011-12-20 Kompozycja zawierająca co najmniej dwa związki, która indukuje 2,3-dioksygenazę indolaminy (IDO) do leczenia zaburzenia autoimmunologicznego lub immunologicznego odrzucenia narządów

Country Status (8)

Country Link
US (3) US20130309198A1 (enExample)
EP (2) EP2654758B1 (enExample)
JP (1) JP6063392B2 (enExample)
CA (1) CA2822745A1 (enExample)
DK (1) DK2654758T3 (enExample)
ES (1) ES2638818T3 (enExample)
PL (1) PL2654758T3 (enExample)
WO (1) WO2012087234A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105473550B (zh) * 2013-07-01 2019-02-15 百时美施贵宝公司 Ido抑制剂
GB201504701D0 (en) * 2015-03-19 2015-05-06 Idogen Ab Novel treatment method
CN104873731A (zh) * 2015-05-22 2015-09-02 宫兆妮 用于狼疮肾炎的中药
WO2018037108A1 (en) * 2016-08-26 2018-03-01 Idogen Ab Ex vivo methods of inducing ido expression in antigen presenting cells using a compound selected from the group consisting of azacytidine, and decitabine
US11591300B2 (en) 2017-12-21 2023-02-28 The Brigham And Women's Hospital, Inc. Oxazole containing compounds as activators of IDO1 and AhR
US11712425B2 (en) 2018-03-14 2023-08-01 Albert Einstein College Of Medicine Immunoregulatory role of 3-OH-kynurenamine and uses thereof
EP4096720A2 (en) * 2020-01-30 2022-12-07 ModernaTX, Inc. Mrnas encoding metabolic reprogramming polypeptides and uses thereof
WO2024033896A1 (en) * 2022-08-12 2024-02-15 Biorchestra Co., Ltd. Oligonucleotides targeting indoleamine 2,3-dioxygenase and uses thereof
WO2024155564A1 (en) * 2023-01-17 2024-07-25 Regeneron Pharmaceuticals, Inc. Inositol polyphosphate multikinase (ipmk) therapeutic agents or indoleamine 2,3-dioxygenase 2 (ido2) agonists for use in treating b27-negative uveitis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518012B1 (en) * 1999-04-02 2003-02-11 Health Research, Inc. Method for regulating the expression of MHC antigens and CD40 by inhibitors of histone deacetylation
US6613753B2 (en) * 2001-02-21 2003-09-02 Supergen, Inc. Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
WO2006105979A1 (en) * 2005-04-07 2006-10-12 Nycomed Gmbh Sulfonylpyrroles as histone deacetylase inhibitors
DK1879573T3 (da) 2005-05-10 2013-02-25 Incyte Corp Modulatorer af indolamin 2,3-dioxygenase og fremgangsmåder til anvendelse deraf
WO2007017065A2 (en) * 2005-07-27 2007-02-15 Oncomethylome Sciences Sa Angiogenesis inhibition based upon icam 1 or junb expression levels
US20110300142A1 (en) 2007-05-25 2011-12-08 Salford Leif G Use of zeburaline for the treatment of autoimmune diseases or immune rejection of transplants

Also Published As

Publication number Publication date
US20150182592A1 (en) 2015-07-02
EP2654758A1 (en) 2013-10-30
EP2654758A4 (en) 2014-05-07
CA2822745A1 (en) 2012-06-28
EP2654758B1 (en) 2017-04-19
US20180028621A1 (en) 2018-02-01
JP2014500312A (ja) 2014-01-09
WO2012087234A1 (en) 2012-06-28
ES2638818T3 (es) 2017-10-24
US9839674B2 (en) 2017-12-12
DK2654758T3 (en) 2017-07-10
EP3238726A2 (en) 2017-11-01
US20130309198A1 (en) 2013-11-21
JP6063392B2 (ja) 2017-01-18
EP3238726A3 (en) 2018-01-10

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