PL2480540T3 - Pentahydrat chlorku metylotioninowego, jego wytwarzanie i zastosowanie farmaceutyczne - Google Patents
Pentahydrat chlorku metylotioninowego, jego wytwarzanie i zastosowanie farmaceutyczneInfo
- Publication number
- PL2480540T3 PL2480540T3 PL10771180T PL10771180T PL2480540T3 PL 2480540 T3 PL2480540 T3 PL 2480540T3 PL 10771180 T PL10771180 T PL 10771180T PL 10771180 T PL10771180 T PL 10771180T PL 2480540 T3 PL2480540 T3 PL 2480540T3
- Authority
- PL
- Poland
- Prior art keywords
- preparation
- pharmaceutical use
- methylthioninium chloride
- chloride pentahydrate
- pentahydrate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24537209P | 2009-09-24 | 2009-09-24 | |
| EP10771180.6A EP2480540B1 (en) | 2009-09-24 | 2010-09-23 | Methylthioninium chloride pentahydrate, preparation and pharmaceutical use thereof |
| PCT/IB2010/002543 WO2011036561A2 (en) | 2009-09-24 | 2010-09-23 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2480540T3 true PL2480540T3 (pl) | 2018-05-30 |
Family
ID=43662090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10771180T PL2480540T3 (pl) | 2009-09-24 | 2010-09-23 | Pentahydrat chlorku metylotioninowego, jego wytwarzanie i zastosowanie farmaceutyczne |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8901296B2 (pl) |
| EP (1) | EP2480540B1 (pl) |
| JP (2) | JP5918136B2 (pl) |
| KR (1) | KR101728574B1 (pl) |
| CN (1) | CN102666510B (pl) |
| AU (1) | AU2010299574B2 (pl) |
| BR (1) | BR112012006626B8 (pl) |
| CA (1) | CA2773306C (pl) |
| DK (1) | DK2480540T3 (pl) |
| ES (1) | ES2659091T3 (pl) |
| HR (1) | HRP20180347T1 (pl) |
| MX (1) | MX2012003035A (pl) |
| MY (1) | MY161463A (pl) |
| PL (1) | PL2480540T3 (pl) |
| PT (1) | PT2480540T (pl) |
| SI (1) | SI2480540T1 (pl) |
| WO (1) | WO2011036561A2 (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9192611B2 (en) * | 2010-11-30 | 2015-11-24 | Wista Laboratories Ltd. | Formulations comprising methylthioninium chloride |
| KR102475825B1 (ko) | 2016-07-25 | 2022-12-08 | 위스타 레보레이토리스 리미티드 | 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage) |
| GB201614834D0 (en) * | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| WO2023232764A1 (en) | 2022-05-31 | 2023-12-07 | Wista Laboratories Ltd. | Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds |
| WO2024061971A1 (en) | 2022-09-21 | 2024-03-28 | Wista Laboratories Ltd. | Novel formulations and vehicles |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1425577A4 (en) * | 2001-08-10 | 2004-12-29 | Symyx Technologies Inc | APPARATUSES AND METHODS FOR PREPARING AND TESTING PRE-FORMULATIONS AND CORRESPONDING SYSTEMS |
| US7790881B2 (en) * | 2004-09-23 | 2010-09-07 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| SI2322517T1 (sl) | 2004-09-23 | 2019-06-28 | Wista Laboratories Ltd. | Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC) |
| ES2349322T7 (es) * | 2006-03-29 | 2019-10-17 | Wista Lab Ltd | Sales de 3,7-diamino-10H-fenotiazina y su utilización |
| DK3792254T3 (da) * | 2009-09-24 | 2023-09-25 | Wista Lab Ltd | Krystallinske methylthioninium-chloridhydrater |
-
2010
- 2010-09-23 MY MYPI2012001321A patent/MY161463A/en unknown
- 2010-09-23 ES ES10771180.6T patent/ES2659091T3/es active Active
- 2010-09-23 DK DK10771180.6T patent/DK2480540T3/en active
- 2010-09-23 AU AU2010299574A patent/AU2010299574B2/en active Active
- 2010-09-23 MX MX2012003035A patent/MX2012003035A/es active IP Right Grant
- 2010-09-23 CN CN201080053177.8A patent/CN102666510B/zh active Active
- 2010-09-23 WO PCT/IB2010/002543 patent/WO2011036561A2/en active Application Filing
- 2010-09-23 JP JP2012530358A patent/JP5918136B2/ja active Active
- 2010-09-23 PT PT107711806T patent/PT2480540T/pt unknown
- 2010-09-23 US US13/497,691 patent/US8901296B2/en active Active
- 2010-09-23 BR BR112012006626A patent/BR112012006626B8/pt active IP Right Grant
- 2010-09-23 EP EP10771180.6A patent/EP2480540B1/en active Active
- 2010-09-23 PL PL10771180T patent/PL2480540T3/pl unknown
- 2010-09-23 CA CA2773306A patent/CA2773306C/en active Active
- 2010-09-23 KR KR1020127009858A patent/KR101728574B1/ko active IP Right Grant
- 2010-09-23 SI SI201031633T patent/SI2480540T1/en unknown
-
2015
- 2015-11-24 JP JP2015228627A patent/JP2016074699A/ja active Pending
-
2018
- 2018-02-26 HR HRP20180347TT patent/HRP20180347T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010299574B2 (en) | 2013-09-26 |
| JP2013505926A (ja) | 2013-02-21 |
| WO2011036561A2 (en) | 2011-03-31 |
| CN102666510A (zh) | 2012-09-12 |
| MX2012003035A (es) | 2012-06-12 |
| BR112012006626B8 (pt) | 2021-05-25 |
| BR112012006626A2 (pt) | 2016-05-03 |
| KR20120099410A (ko) | 2012-09-10 |
| DK2480540T3 (en) | 2018-01-22 |
| US8901296B2 (en) | 2014-12-02 |
| JP5918136B2 (ja) | 2016-05-18 |
| JP2016074699A (ja) | 2016-05-12 |
| CN102666510B (zh) | 2016-09-14 |
| KR101728574B1 (ko) | 2017-04-19 |
| US20120289499A1 (en) | 2012-11-15 |
| ES2659091T3 (es) | 2018-03-13 |
| PT2480540T (pt) | 2018-02-16 |
| AU2010299574A1 (en) | 2012-03-29 |
| EP2480540B1 (en) | 2017-11-29 |
| WO2011036561A3 (en) | 2011-05-19 |
| CA2773306C (en) | 2018-04-24 |
| WO2011036561A8 (en) | 2012-04-19 |
| CA2773306A1 (en) | 2011-03-31 |
| SI2480540T1 (en) | 2018-03-30 |
| MY161463A (en) | 2017-04-14 |
| EP2480540A2 (en) | 2012-08-01 |
| BR112012006626B1 (pt) | 2021-04-20 |
| HRP20180347T1 (hr) | 2018-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL217208A0 (en) | Novel conjugates, preparation thereof, and therapeutic use thereof | |
| ZA201300685B (en) | Anticancer derivatives,preparation thereof and therapeutic use thereof | |
| HK1161878A1 (en) | Dihydropteridinone derivatives, preparation process and pharmaceutical use thereof | |
| IL231386A (en) | Pyrazolequinoline derivatives, their preparation and medical use | |
| IL214175A (en) | Derivatives of aminotetralin, their pharmaceutical compositions and their use | |
| ZA201300957B (en) | 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and use thereof | |
| PL2655375T3 (pl) | Pochodne pirymidynonu, ich wytwarzanie i ich farmaceutyczne zastosowanie | |
| HK1159108A1 (en) | Pyridino-pyridinone derivatives, preparation thereof, and therapeutic use thereof | |
| HK1167597A1 (en) | Dodeca-2e,4e-diene amides and their use as medicaments and cosmetics -2e4e- | |
| HK1151791A1 (en) | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | |
| IL219888A0 (en) | Pyridine-pyridinone derivatives, preparation and therapeutic use thereof | |
| IL215835A (en) | Carboxamide compounds and their use as a drug | |
| GB0915196D0 (en) | Therapeutic compounds and their use | |
| IL216105A0 (en) | Non-cating salt composition, preparation process and use thereof | |
| GB0920258D0 (en) | New medical agents and use thereof | |
| ZA201107363B (en) | Quinazolinedione derivatives,preparation thereof and various therapeutic uses thereof | |
| PL2480540T3 (pl) | Pentahydrat chlorku metylotioninowego, jego wytwarzanie i zastosowanie farmaceutyczne | |
| GB0908425D0 (en) | Medical use | |
| HK1164861A1 (en) | Substituted 3-benzofuranyl-indol-2-one-3-acetamidopiperazine derivatives, preparation thereof, and therapeutic use thereof | |
| HK1164883A1 (en) | Carvedilol sulfate crystals, preparation methods and pharmaceutical use thereof | |
| SI2603217T1 (sl) | Novi 6,7-disubstituirani-isokinolinski derivati in njihova uporaba | |
| IL202474A0 (en) | 1-benzylpyrazole derivatives, preparation thereof and therapeutic use thereof | |
| SI2421864T1 (sl) | 1-pirazolo(4,3-c)izokinolinski derivati, njihova priprava in njihova terapevtska uporaba | |
| IL226388A0 (en) | New indolizine derivatives, their preparation and medical use | |
| EP2621490A4 (en) | PROPARGYL-TRIFLUOROMETHOXY-AMINO-BENZOTHIAZOLE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF |