PL2257587T3 - Polimer pochodny polietylenoiminy liniowej do transferu genów - Google Patents

Polimer pochodny polietylenoiminy liniowej do transferu genów

Info

Publication number
PL2257587T3
PL2257587T3 PL09720962T PL09720962T PL2257587T3 PL 2257587 T3 PL2257587 T3 PL 2257587T3 PL 09720962 T PL09720962 T PL 09720962T PL 09720962 T PL09720962 T PL 09720962T PL 2257587 T3 PL2257587 T3 PL 2257587T3
Authority
PL
Poland
Prior art keywords
gene transfer
polymer derived
linear polyethylenimine
polyethylenimine
linear
Prior art date
Application number
PL09720962T
Other languages
English (en)
Inventor
Hervé Cheradame
Mathieu Sassatelli
Philippe Guegan
Patrick Midoux
Chantal Pichon
Original Assignee
Centre National De La Recherche Scientifique (Cnrs)
Université d'Orléans
Universite D'evry Val D'essonne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National De La Recherche Scientifique (Cnrs), Université d'Orléans, Universite D'evry Val D'essonne filed Critical Centre National De La Recherche Scientifique (Cnrs)
Publication of PL2257587T3 publication Critical patent/PL2257587T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/02—Polyamines
PL09720962T 2008-03-05 2009-03-04 Polimer pochodny polietylenoiminy liniowej do transferu genów PL2257587T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0851434A FR2928373B1 (fr) 2008-03-05 2008-03-05 Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
PCT/EP2009/052530 WO2009112402A1 (fr) 2008-03-05 2009-03-04 Polymere derive de la polyethylenimine lineaire pour le transfert de gene
EP09720962.1A EP2257587B1 (fr) 2008-03-05 2009-03-04 Polymere derive de la polyethylenimine lineaire pour le transfert de gene

Publications (1)

Publication Number Publication Date
PL2257587T3 true PL2257587T3 (pl) 2020-01-31

Family

ID=39746665

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09720962T PL2257587T3 (pl) 2008-03-05 2009-03-04 Polimer pochodny polietylenoiminy liniowej do transferu genów

Country Status (9)

Country Link
US (1) US8658150B2 (pl)
EP (1) EP2257587B1 (pl)
CA (1) CA2717778C (pl)
DK (1) DK2257587T3 (pl)
ES (1) ES2744827T3 (pl)
FR (1) FR2928373B1 (pl)
IL (1) IL207975A (pl)
PL (1) PL2257587T3 (pl)
WO (1) WO2009112402A1 (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101974154B (zh) * 2010-11-10 2012-07-25 中国科学院长春应用化学研究所 一种改性聚乙烯亚胺及其制备方法
ES2729787T3 (es) 2011-01-04 2019-11-06 Gatt Tech B V Polímeros reticulados e implantes derivados de la polioxazolina activada de forma electrófila
US9180202B2 (en) 2012-01-02 2015-11-10 Universiteit Gent Polyoxazoline polymers and methods for their preparation, conjugates of these polymers and medical uses thereof
JP6178399B2 (ja) 2012-03-16 2017-08-09 ベンデル アナリティカル ホールディング ビー．ブイ．Ｂｅｎｄｅｒ Ａｎａｌｙｔｉｃａｌ Ｈｏｌｄｉｎｇ Ｂ．Ｖ． 求核的に活性化したポリオキサゾリンに由来する架橋ポリマー及び医療製品
US10232077B2 (en) 2014-10-06 2019-03-19 Gatt Technologies B.V. Tissue-adhesive porous haemostatic product
FR3027533A1 (fr) 2014-10-24 2016-04-29 Univ Pierre Et Marie Curie (Paris 6) Preparation de polyplexes monoplasmidiques
JP6609151B2 (ja) * 2015-09-30 2019-11-20 株式会社日本触媒 ポリアルキレンイミン誘導体
CN114450326A (zh) * 2019-06-24 2022-05-06 普罗美加公司 用于将生物分子递送到细胞中的改性聚胺聚合物
JP2022543823A (ja) * 2019-08-05 2022-10-14 ポリプラス トランスフェクション カチオン性ポリマーにグラフトした複素環化合物を含む核酸分子を細胞にトランスフェクトするための組成物及びその用途
FR3108330B1 (fr) 2020-03-23 2023-11-17 Polytheragene Copolymere lineaire pour la transfection de genes
CN113603886A (zh) * 2021-08-10 2021-11-05 中国科学院长春应用化学研究所 一种聚乙烯亚胺衍生物及其制备方法和应用
FR3136375A1 (fr) * 2022-06-08 2023-12-15 Centre National De La Recherche Scientifique (Cnrs) Microbulles lipidiques pour la délivrance ciblée d’actifs
CN116478410B (zh) * 2023-06-20 2023-09-12 觅投克(北京)生物医学技术有限公司 一种菊糖修饰的聚乙烯亚胺衍生物及其制备方法和应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87142A1 (fr) 1988-02-25 1989-09-20 Oreal Societe Anonyme Francais Composition cosmetique pour le maintien de la coiffure contenant un polymere d'oxazoline et un acide 2-hydroxy 4-methoxy benzophenone 5-sulfonique salifie ou non
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
DE4319934A1 (de) * 1993-06-16 1994-12-22 Basf Ag Gepfropfte Polyamidoamine und gepfropfte Polyethylenimine, Verfahren zu ihrer Herstellung und ihre Verwendung als Zusatz zu Waschmitteln
FR2719316B1 (fr) * 1994-04-28 1996-05-31 Idm Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules.
FR2722506B1 (fr) * 1994-07-13 1996-08-14 Rhone Poulenc Rorer Sa Composition contenant des acides nucleiques, preparation et utilisations
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US6190865B1 (en) 1995-09-27 2001-02-20 Epicentre Technologies Corporation Method for characterizing nucleic acid molecules
FR2755976B1 (fr) * 1996-11-15 1999-01-15 Idm Immuno Designed Molecules Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires
DE19743135A1 (de) * 1997-09-30 1999-04-01 Hoechst Marion Roussel De Gmbh Biologisch verträgliche niedermolekular Polyethylenimine
US5985938A (en) 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US7396919B1 (en) 1998-07-17 2008-07-08 Mirus Bio Corporation Charge reversal of polyion complexes
ES2191269T3 (es) 1998-08-28 2003-09-01 Transgene Sa Uso de un polimero cationico para obtener un complejo de acido nucleico y composiciones afines.
DE69915103T2 (de) 1998-12-02 2004-12-09 I.D.M. Immuno-Designed Molecules Neue oligomere konjugate zum transfer biologischer moleküle in zellen
EP1074248A1 (en) 1999-07-08 2001-02-07 Arnold Hilgers Delivery system for biological material
CA2394758A1 (en) * 1999-12-29 2001-07-05 A. James Mixson Histidine-containing copolymers enhance pharmaceutical agent delivery
FR2814370B1 (fr) * 2000-09-22 2004-08-20 Centre Nat Rech Scient Utilisation d'un complexe acide nucleique/pei pour le ciblage de cellules souches du cerveau
AU2001289943A1 (en) * 2000-10-09 2002-04-22 Bayer Aktiengesellschaft Complexes for transferring nucleic acids into cells
DE60124779T2 (de) * 2000-12-29 2007-09-13 The Board Of Regents Of The University Of Oklahoma, Norman Leitendes elektrolyt auf basis von polyaminen
DE10124387A1 (de) * 2001-05-18 2002-11-28 Basf Ag Hydrophob modifizierte Polyethylenimine und Polyvinylamine zur Antiknitterausrüstung von cellulosehaltigen Textilien
US6586524B2 (en) 2001-07-19 2003-07-01 Expression Genetics, Inc. Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier
EP1575976A4 (en) 2001-11-02 2006-08-23 Insert Therapeutics Inc METHODS AND COMPOSITIONS FOR THE THERAPEUTIC USE OF RNA INTERFERENCE
US20030147958A1 (en) * 2002-01-29 2003-08-07 Cheol-Hee Ahn Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents
GB0221942D0 (en) 2002-09-20 2002-10-30 Univ Strathclyde Drug delivery
FR2849602B1 (fr) * 2003-01-06 2008-09-05 Assist Publ Hopitaux De Paris Solutions injectables gelifiantes a base de polymeres reticules et non reticules, et leurs applications
WO2004099288A1 (en) 2003-05-09 2004-11-18 Carlsberg A/S Polyethyleneimine polymers
US8057821B2 (en) * 2004-11-03 2011-11-15 Egen, Inc. Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
FR2889066B1 (fr) * 2005-07-28 2007-11-09 Centre Nat Rech Scient Procede d'immunisation genetique par electrotransfert contre une toxine et antiserum susceptible d'etre obtenu par ledit procede
EP1844772A1 (en) 2006-04-06 2007-10-17 Polyplus-Transfection SA Compositions for transfection of oligonucleotides active for gene silencing and their biological and therapeutical applications

Also Published As

Publication number Publication date
IL207975A0 (en) 2010-12-30
FR2928373B1 (fr) 2010-12-31
EP2257587A1 (fr) 2010-12-08
FR2928373A1 (fr) 2009-09-11
US8658150B2 (en) 2014-02-25
CA2717778C (fr) 2017-12-05
CA2717778A1 (fr) 2009-09-17
DK2257587T3 (da) 2019-08-26
IL207975A (en) 2014-12-31
US20110091407A1 (en) 2011-04-21
EP2257587B1 (fr) 2019-06-12
ES2744827T3 (es) 2020-02-26
WO2009112402A1 (fr) 2009-09-17

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