PL2222678T3 - Sposoby wytwarzania związków morfinanowych (+)-'nal' - Google Patents

Sposoby wytwarzania związków morfinanowych (+)-'nal'

Info

Publication number
PL2222678T3
PL2222678T3 PL08862059.6T PL08862059T PL2222678T3 PL 2222678 T3 PL2222678 T3 PL 2222678T3 PL 08862059 T PL08862059 T PL 08862059T PL 2222678 T3 PL2222678 T3 PL 2222678T3
Authority
PL
Poland
Prior art keywords
nal
processes
production
morphinan compounds
morphinan
Prior art date
Application number
PL08862059.6T
Other languages
English (en)
Inventor
Peter X. Wang
Tao Jiang
Gary L. Cantrell
David W. Berberich
Bobby N. Trawick
Subo Liao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2222678T3 publication Critical patent/PL2222678T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL08862059.6T 2007-12-17 2008-12-17 Sposoby wytwarzania związków morfinanowych (+)-'nal' PL2222678T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1410207P 2007-12-17 2007-12-17

Publications (1)

Publication Number Publication Date
PL2222678T3 true PL2222678T3 (pl) 2016-09-30

Family

ID=40340537

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08862059.6T PL2222678T3 (pl) 2007-12-17 2008-12-17 Sposoby wytwarzania związków morfinanowych (+)-'nal'

Country Status (9)

Country Link
US (1) US8067596B2 (pl)
EP (1) EP2222678B1 (pl)
JP (2) JP5587204B2 (pl)
AU (1) AU2008338906B2 (pl)
CA (1) CA2709886C (pl)
ES (1) ES2569655T3 (pl)
NZ (1) NZ586194A (pl)
PL (1) PL2222678T3 (pl)
WO (1) WO2009079013A1 (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
US20120142720A1 (en) 2009-07-02 2012-06-07 Kempharm, Inc. Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof
WO2012018871A1 (en) * 2010-08-04 2012-02-09 Mallinckrodt Llc Tandem process for preparing n-alkyl morphinans
KR20140047609A (ko) 2011-05-06 2014-04-22 브럭 유니버시티 금속 촉매된 n-탈메틸화/기능화 및 분자내 기 전이를 통한 모르핀 아날로그의 제조 방법
CA2880446C (en) * 2012-08-03 2018-03-13 Johnson Matthey Public Limited Company A method for preparing oxycodone
TWI513697B (zh) 2012-12-14 2015-12-21 Purdue Pharma Lp 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
US8937084B2 (en) 2012-12-14 2015-01-20 Purdue Pharma L.P. Nitrogen containing morphinan derivatives and the use thereof
WO2014091297A1 (en) 2012-12-14 2014-06-19 Purdue Pharma L.P. Spirocyclic morphinans and their use
US8946255B2 (en) 2012-12-28 2015-02-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
US8957084B2 (en) 2012-12-28 2015-02-17 Purdue Pharma L.P. 7,8-cyclicmorphinan analogs
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
EP3087079B1 (en) 2013-12-26 2019-04-03 Purdue Pharma LP Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
EP3087073B1 (en) 2013-12-26 2018-07-04 Purdue Pharma LP 10-substituted morphinan hydantoins
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US9850252B2 (en) 2014-11-25 2017-12-26 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone, prodrugs, methods of making and use thereof
WO2016187522A1 (en) * 2015-05-20 2016-11-24 Noramco, Inc. Process for the preparation of oxymorphone freebase
CN111698987B (zh) * 2017-12-12 2024-08-13 萨鲁德医疗公司 吗啡烷的卤代衍生物及其用途
WO2021195209A1 (en) * 2020-03-24 2021-09-30 University Of Padova Morphinan isomers and their structural modifications as nmdar antagonists and neuroplastogens
WO2021249708A1 (en) 2020-06-10 2021-12-16 Research Center Pharmaceutical Engineering Gmbh Processes for preparing nor-opioid compounds and opioid antagonists by electrochemical n-demethylation
EP4714955A1 (en) * 2023-05-18 2026-03-25 Shaoxing Zejun Pharmaceuticals Co., Ltd Versatile intermediate for opioid derivatives, and preparation method therefor and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL26896A (en) 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US4322426A (en) 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
IT1199871B (it) * 1984-03-27 1989-01-05 Mallinckrodt Inc Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
ES2357216T3 (es) * 2005-06-16 2011-04-20 Mallinckrodt, Inc. Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.

Also Published As

Publication number Publication date
CA2709886C (en) 2016-10-25
JP5587204B2 (ja) 2014-09-10
EP2222678A1 (en) 2010-09-01
WO2009079013A1 (en) 2009-06-25
US8067596B2 (en) 2011-11-29
JP2014055179A (ja) 2014-03-27
ES2569655T3 (es) 2016-05-12
JP2011506609A (ja) 2011-03-03
NZ586194A (en) 2012-07-27
EP2222678B1 (en) 2016-03-09
AU2008338906A1 (en) 2009-06-25
AU2008338906B2 (en) 2013-06-27
CA2709886A1 (en) 2009-06-25
US20090156820A1 (en) 2009-06-18

Similar Documents

Publication Publication Date Title
PL2222678T3 (pl) Sposoby wytwarzania związków morfinanowych (+)-'nal'
DK3872059T3 (en) Process for the preparation of 2,3,3,3 tetrahydrofluoropropene
PL2222642T3 (pl) Sposób i związki do wytwarzania (+) opiatów
TWI449540B (en) Process for the production of an abuse-proofed dosage form
ZA200905012B (en) Process for the preparation of certain substituted sulfimines
EP1893570A4 (en) IMPROVED PROCESS FOR THE PREPARATION OF EZETIMIBE
PL2170785T3 (pl) Sposób wytwarzania fluorowodoroolefin
IL201245A0 (en) An improved process for the synthesis of solifenacin
IL202046A0 (en) Process for the manufacture of p4o6
GB2462234B (en) Process for the separation of diastereomers
ZA200903889B (en) Process for the synthesis of moxifloxacin hydrochloride
GB0702854D0 (en) Method for the synthesis of sucrose-6-esters
ZA200907191B (en) Process for the preparation of gefitiib
ZA200804264B (en) Process for the preparation of ferri-succinylcasein
ZA201003241B (en) Method for the preparation of morphine compounds
EP1861408A4 (en) PROCESS FOR PRODUCING HYDROCHLOROSILANES
SI1807395T1 (sl) Proces za sintezo N-alkoksiaminov
PL385440A1 (pl) Sposób wytwarzania 4'-O- -D-glukozylo-2',4-dihydroksy-6'-metoksy-3'-prenylochalkonu
ZA201000394B (en) Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
EP1996192A4 (en) PROCESS FOR PREPARING 3,4-SUBSTITUTED THIAZOLIDIN-2-ONES IN 3,4
ZA200601910B (en) Process for the preparation of organosilances
PL2137202T3 (pl) Sposób syntezy IB-MECA
IL194330A0 (en) Processes for the synthesis of 3-isobutylglutaric acid
GB2459413B (en) Methods for the synthesis of perfluoroparacyclophane
EP2170902A4 (en) IMPROVED METHOD FOR SYNTHESIS OF OLANZAPINE