PL2170877T3 - Podstawione (oksazolidynon-5-ylometylo)-2-tiofenokarboksamidy i ich zastosowanie w dziedzinie krzepnięcia krwi - Google Patents

Podstawione (oksazolidynon-5-ylometylo)-2-tiofenokarboksamidy i ich zastosowanie w dziedzinie krzepnięcia krwi

Info

Publication number
PL2170877T3
PL2170877T3 PL08773372T PL08773372T PL2170877T3 PL 2170877 T3 PL2170877 T3 PL 2170877T3 PL 08773372 T PL08773372 T PL 08773372T PL 08773372 T PL08773372 T PL 08773372T PL 2170877 T3 PL2170877 T3 PL 2170877T3
Authority
PL
Poland
Prior art keywords
oxazolidinon
carboxamides
thiophene
substituted
methyl
Prior art date
Application number
PL08773372T
Other languages
English (en)
Polish (pl)
Inventor
Swen Allerheiligen
Marcus Bauser
Dirk Heimbach
Stefan Heitmeier
Mark Jean Gnoth
Christoph Gerdes
Degenfeld Georges Von
Susanne Röhrig
Ulrich Rester
Elke Dittrich-Wengenroth
Uwe Saatmann
Adrian Tersteegen
Joachim Krüger
Holger Paulsen
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39731148&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2170877(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of PL2170877T3 publication Critical patent/PL2170877T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
PL08773372T 2007-06-20 2008-06-07 Podstawione (oksazolidynon-5-ylometylo)-2-tiofenokarboksamidy i ich zastosowanie w dziedzinie krzepnięcia krwi PL2170877T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007028319A DE102007028319A1 (de) 2007-06-20 2007-06-20 Substituierte Oxazolidinone und ihre Verwendung
PCT/EP2008/004562 WO2008155032A1 (fr) 2007-06-20 2008-06-07 (oxazolidinon-5-yl-méthyl)-2-thiophène-carboxamides substitués et leur utilisation dans le domaine de la coagulation sanguine
EP08773372A EP2170877B1 (fr) 2007-06-20 2008-06-07 (oxazolidinon-5-yl-méthyl)-2-thiophène-carboxamides substitués et leur utilisation dans le domaine de la coagulation sanguine

Publications (1)

Publication Number Publication Date
PL2170877T3 true PL2170877T3 (pl) 2013-03-29

Family

ID=39731148

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08773372T PL2170877T3 (pl) 2007-06-20 2008-06-07 Podstawione (oksazolidynon-5-ylometylo)-2-tiofenokarboksamidy i ich zastosowanie w dziedzinie krzepnięcia krwi

Country Status (43)

Country Link
US (2) US8383822B2 (fr)
EP (1) EP2170877B1 (fr)
JP (1) JP5537421B2 (fr)
KR (1) KR101535312B1 (fr)
CN (1) CN101821259B (fr)
AR (2) AR066981A1 (fr)
AU (1) AU2008266525B8 (fr)
BR (1) BRPI0813736A2 (fr)
CA (1) CA2692166C (fr)
CL (1) CL2008001691A1 (fr)
CO (1) CO6251281A2 (fr)
CR (1) CR11168A (fr)
CU (1) CU23820A3 (fr)
CY (1) CY1113580T1 (fr)
DE (1) DE102007028319A1 (fr)
DK (1) DK2170877T5 (fr)
DO (1) DOP2009000285A (fr)
EC (1) ECSP099807A (fr)
ES (1) ES2397799T3 (fr)
GT (1) GT200900319A (fr)
HK (1) HK1147991A1 (fr)
HN (1) HN2009003424A (fr)
HR (1) HRP20130072T1 (fr)
IL (1) IL202351A (fr)
JO (1) JO2798B1 (fr)
MA (1) MA31535B1 (fr)
MX (1) MX2009013711A (fr)
MY (1) MY150931A (fr)
NZ (1) NZ581540A (fr)
PA (1) PA8784301A1 (fr)
PE (1) PE20090332A1 (fr)
PL (1) PL2170877T3 (fr)
PT (1) PT2170877E (fr)
RS (1) RS52639B (fr)
RU (1) RU2481345C2 (fr)
SG (1) SG182220A1 (fr)
SI (1) SI2170877T1 (fr)
SV (1) SV2009003435A (fr)
TN (1) TN2009000503A1 (fr)
TW (1) TWI413642B (fr)
UA (1) UA98793C2 (fr)
UY (1) UY31133A1 (fr)
WO (1) WO2008155032A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028407A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102010028362A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Herstellverfahren
CN102464658B (zh) * 2010-11-03 2014-04-16 天津药物研究院 噁唑烷酮衍生物及其制备方法和用途
EP2665751A1 (fr) 2011-01-19 2013-11-27 Bayer Intellectual Property GmbH Protéines de liaison à des inhibiteurs de facteurs de coagulation
CN103626749A (zh) * 2012-08-21 2014-03-12 苏州泽璟生物制药有限公司 取代的噁唑烷酮化合物和包含该化合物的药物组合物及其用途
CN104163819A (zh) * 2013-05-17 2014-11-26 天津药物研究院 一种噁唑烷酮衍生物的乙酸溶剂化物及其制备方法和用途
CN103242307B (zh) * 2013-05-17 2015-08-12 天津药物研究院有限公司 一种噁唑烷酮类衍生物晶型ⅰ及其制备方法和用途
CN103232446B (zh) * 2013-05-17 2015-09-23 天津药物研究院 一种噁唑烷酮衍生物晶型ⅱ及其制备方法和用途

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
DE4319041A1 (de) 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
DE19642255A1 (de) 1996-10-14 1998-04-16 Bayer Ag Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten
ES2325045T3 (es) 1996-10-14 2009-08-24 Bayer Healthcare Ag Nuevos derivados de pirazol heterociclilmetil sustituidos y su uso en el tratamiento de enfermedades cardiovasculares.
DE19649460A1 (de) 1996-11-26 1998-05-28 Bayer Ag Neue substituierte Pyrazolderivate
DE19834045A1 (de) 1998-07-29 2000-02-03 Bayer Ag (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19846514A1 (de) 1998-10-09 2000-04-20 Bayer Ag Neue Heterocyclyl-methyl-substituierte Pyrazole
WO2000024227A1 (fr) 1998-10-16 2000-04-27 Medical Solutions, Inc. Systeme et procede de regulation de temperature pour le chauffage et le maintien d'articles medicaux a des temperatures voulues
DE19920352A1 (de) 1999-05-04 2000-11-09 Bayer Ag Substituiertes Pyrazolderivat
DE60022508T2 (de) 1999-06-14 2006-06-08 Eli Lilly And Co., Indianapolis Inhibitoren von serin proteasen
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
JP2003518117A (ja) * 1999-12-21 2003-06-03 ファルマシア・アンド・アップジョン・カンパニー スルホキシミン官能基を有するオキサゾリジノンおよび抗微生物剤としてのその使用
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
GB0114005D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
GB0114004D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
TWI257389B (en) 2001-06-12 2006-07-01 Lilly Co Eli Pharmaceutical compound
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
CA2452513A1 (fr) * 2001-07-12 2003-01-23 Pharmacia & Upjohn Company Compose contenant des amides presentant une meilleure solubilite et procede pour ameliorer la solubilite d'un compose contenant des amides
CA2726702A1 (fr) 2001-09-21 2003-04-03 Bristol-Myers Squibb Company Composes contenant du lactame et leurs derives en tant qu'inhibiteurs du facteur xa
TW200303201A (en) 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
PE20040804A1 (es) 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa
US7205318B2 (en) 2003-03-18 2007-04-17 Bristol-Myers Squibb Company Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors
DE10322469A1 (de) 2003-05-19 2004-12-16 Bayer Healthcare Ag Heterocyclische Verbindungen
US7265140B2 (en) * 2003-09-23 2007-09-04 Pfizer Inc Acyloxymethylcarbamate prodrugs of oxazolidinones
CA2545730C (fr) 2003-11-12 2014-07-08 Daiichi Pharmaceutical Co., Ltd. Procede de production de derive de thiazole
DE10355461A1 (de) * 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
JP2005179272A (ja) 2003-12-19 2005-07-07 Yamanouchi Pharmaceut Co Ltd カルボキサミド誘導体のマロン酸塩結晶
DE102004002044A1 (de) * 2004-01-15 2005-08-04 Bayer Healthcare Ag Herstellverfahren
GB0405272D0 (en) 2004-03-09 2004-04-21 Trigen Ltd Compounds
CA2565437A1 (fr) * 2004-06-18 2006-01-05 Millennium Pharmaceuticals, Inc. Inhibiteurs du facteurs xa
US20060069260A1 (en) * 2004-09-28 2006-03-30 Huiping Zhang Preparation of N-aryl pyridones
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
US20090076015A1 (en) 2005-03-31 2009-03-19 Hidemitsu Nishida Tricyclic Spiro Compound Comprising Acyl Group Bound to Nitrogen Atom in the Ring
CN101218227A (zh) 2005-07-08 2008-07-09 阿斯利康(瑞典)有限公司 作为因子Xa的抑制剂的杂环磺酰胺衍生物
AR057976A1 (es) * 2005-08-29 2008-01-09 Boehringer Ingelheim Int Biarilos sustituidos y su uso como medicamentos.
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005050376A1 (de) 2005-10-21 2007-05-31 Bayer Healthcare Ag Dicarbonsäure-Derivate und ihre Verwendung
DE102005050498A1 (de) 2005-10-21 2007-06-06 Bayer Healthcare Aktiengesellschaft Cyclopropylessigsäure-Derivate und ihre Verwendung
DE102005050375A1 (de) 2005-10-21 2007-04-26 Bayer Healthcare Ag Tetrazol-Derivate und ihre Verwendung
DE102005050377A1 (de) 2005-10-21 2007-04-26 Bayer Healthcare Ag Heterocyclische Verbindungen und ihre Verwendung
DE102005050497A1 (de) 2005-10-21 2007-04-26 Bayer Healthcare Ag Difluorphenol-Derivate und ihre Verwendung
DE102006025314A1 (de) * 2006-05-31 2007-12-06 Bayer Healthcare Ag Arylsubstituierte Heterozyklen und ihre Verwendung
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028407A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028406A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung

Also Published As

Publication number Publication date
MY150931A (en) 2014-03-14
HRP20130072T1 (hr) 2013-02-28
PA8784301A1 (es) 2009-02-09
PE20090332A1 (es) 2009-04-09
TW200911797A (en) 2009-03-16
CR11168A (es) 2010-06-28
HN2009003424A (es) 2012-01-05
SG182220A1 (en) 2012-07-30
US8383822B2 (en) 2013-02-26
ES2397799T3 (es) 2013-03-11
MX2009013711A (es) 2010-02-01
WO2008155032A1 (fr) 2008-12-24
IL202351A0 (en) 2010-06-30
DOP2009000285A (es) 2010-01-31
SV2009003435A (es) 2010-08-23
TWI413642B (zh) 2013-11-01
KR101535312B1 (ko) 2015-07-09
CY1113580T1 (el) 2016-06-22
JP2010530383A (ja) 2010-09-09
AR066981A1 (es) 2009-09-23
RU2010101307A (ru) 2011-07-27
MA31535B1 (fr) 2010-07-01
RU2481345C2 (ru) 2013-05-10
ECSP099807A (es) 2010-01-29
DK2170877T5 (da) 2013-03-04
DE102007028319A1 (de) 2008-12-24
CU20090216A7 (es) 2011-10-14
PT2170877E (pt) 2013-01-28
US8846934B2 (en) 2014-09-30
AR067057A1 (es) 2009-09-30
NZ581540A (en) 2012-01-12
CO6251281A2 (es) 2011-02-21
AU2008266525B8 (en) 2013-09-19
KR20100021615A (ko) 2010-02-25
HK1147991A1 (en) 2011-08-26
GT200900319A (es) 2011-11-09
EP2170877A1 (fr) 2010-04-07
BRPI0813736A2 (pt) 2014-12-30
IL202351A (en) 2015-10-29
US20100184740A1 (en) 2010-07-22
DK2170877T3 (da) 2013-02-11
TN2009000503A1 (en) 2011-03-31
US20140057951A1 (en) 2014-02-27
CN101821259A (zh) 2010-09-01
JO2798B1 (en) 2014-03-15
CU23820A3 (es) 2012-06-21
UA98793C2 (ru) 2012-06-25
SI2170877T1 (sl) 2013-03-29
CA2692166C (fr) 2015-01-27
CA2692166A1 (fr) 2008-12-24
AU2008266525A1 (en) 2008-12-24
EP2170877B1 (fr) 2012-11-21
RS52639B (en) 2013-06-28
JP5537421B2 (ja) 2014-07-02
AU2008266525B2 (en) 2013-09-05
UY31133A1 (es) 2009-01-30
CL2008001691A1 (es) 2008-12-26
CN101821259B (zh) 2013-10-30

Similar Documents

Publication Publication Date Title
HK1147991A1 (en) Substituted (oxazolidinon-5-yl-methyl) -2-thiophene-carboxamides and use thereof in the field of blood coagulation
EP2129313A4 (fr) Dispositifs chirurgicaux et leurs procédés d'utilisation
EP2091588A4 (fr) Dispositif cardiaque et ses procédés d'utilisation
HK1142908A1 (en) Pyrazinone derivatives and their use in the treatment of lung diseases
EP2303154A4 (fr) Canule de dissection et procédés d utilisation de celle-ci
EP2317931A4 (fr) Dispositifs de modification de tissu et procédés pour les utiliser
EP2046413A4 (fr) Systèmes médicaux et leurs procédés d'utilisation
EP2054063A4 (fr) Dérivés de 4-aminoquinazoline et leurs procédés d'utilisation
PT2291394T (pt) Proteínas de fusão e seus usos no diagnóstico e tratamento de leishmaniose
GB0708761D0 (en) Improvements in and relating to medical instruments
EP2064550A4 (fr) Compositions associees a prrg4 et procedes d'utilisation de celles-ci dans des procedes de diagnostic de tumeur
ZA200902419B (en) Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases
HK1203482A1 (en) Phenoxypyridinylamide derivatives and their use in the treatment of pde4 mediated disease states pde4
EP2079526A4 (fr) Compositions et leurs utilisations dans le traitement de lésions
EP2170404A4 (fr) Compositions comprenant un arnsi de egfr humain et leurs procédés d'utilisation
IL212672A (en) Cycloandesdepsipeptide compounds and their use in drug production
HK1168283A1 (zh) 類的試劑在治療抗胰島素和相關疾病的用途
HK1143756A1 (en) Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid n-phenylamides in the treatment of pain
ZA201108106B (en) Use of phthalimide derivatives in the treatment of diseases
IL201426A0 (en) Drug combination and its use in the treatment of muscle loss
BRPI1012325A2 (pt) uso de microrna-199b-5p no campo médico e diagnóstico."
GB201020621D0 (en) Pin for hygienic and/or medical use in the anal region
ZA200904755B (en) Use of epothilones in the treatment of osteoporosis and related diseases
EP2201953A4 (fr) Utilisation de la ribavirine dans un trouble de la coagulation du sang
AU2008101066A4 (en) The use of leeches in cardiovascular and vascular disease