CO6251281A2 - (oxazolidinon-5-il-metil)-2- tiofen-carboxamidas sustituidas y su uso en el campo de la coagulacion sanguinea - Google Patents
(oxazolidinon-5-il-metil)-2- tiofen-carboxamidas sustituidas y su uso en el campo de la coagulacion sanguineaInfo
- Publication number
- CO6251281A2 CO6251281A2 CO09144220A CO09144220A CO6251281A2 CO 6251281 A2 CO6251281 A2 CO 6251281A2 CO 09144220 A CO09144220 A CO 09144220A CO 09144220 A CO09144220 A CO 09144220A CO 6251281 A2 CO6251281 A2 CO 6251281A2
- Authority
- CO
- Colombia
- Prior art keywords
- ring
- methyl
- ethyl
- represents hydrogen
- pyrrolidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
1.- Compuesto de fórmulaen la que R1 representa cloro, trifluorometoxi, metilo, etilo, n-propilo, metoxi, metoximetilo o etoximetilo, R2 representa hidrógeno o metilo, y R3 representa un grupo de fórmulaen las que * es el punto de unión al anillo de oxopiridina, n representa el número 1, 2, 3 ó 4, m representa el número 1 ó 2, R4 representa hidrógeno, metilo, etilo, ciclopropilo, ciclobutilo, 2-hidroxiet-1-ilo, 3-hidroxiprop-1-ilo, 2-metoxiet-1-ilo, 3-metoxiprop-1-ilo, 4-hidroxiciclohex-1-ilo, tetrahidrofuran-2-ilmetilo o 1,4-dioxan-2-ilmetilo,R5 representa hidrógeno, metilo o etilo, oR4 y R5 junto con el átomo de nitrógeno al que están unidos forman un anillo de pirrolidin-1-ilo, un anillo de 2-metoximetil-pirrolidin-1-ilo, un anillo de morfolin-4-ilo, un anillo de 1,1-dioxo-tiomorfolin-4-ilo, un anillo de 1,4-oxazepan-4-ilo, un 4-metil-piperazin-1-ilo o un anillo de 4-hidroxi-piperidin-1-ilo, R6 representa hidrógeno, metilo, etilo, ciclopropilo, ciclobutilo, 2-hidroxiet-1-ilo, 3-hidroxiprop-1-ilo, 2-metoxiet-1-ilo, 3-metoxiprop-1-ilo, 4-hidroxiciclohex-1-ilo, tetrahidrofuran-2-ilmetilo o 1,4-dioxan-2-ilmetilo, R7 representa hidrógeno, metilo o etilo, R6 y R7 junto con el átomo de nitrógeno al que están unidos forman un anillo de pirrolidin-1-ilo, un anillo de 2-metoximetil-pirrolidin-1-ilo, un anillo de morfolin-4-ilo, un anillo de 1,1-dioxo-tiomorfolin-4-ilo, un anillo de 1,4-oxazepan-4-ilo, un 4-metil-piperazin-1-ilo o un anillo de 4-hidroxi-piperidin-1-ilo, o una de sus sales, sus solvatos y los solvatos de sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007028319A DE102007028319A1 (de) | 2007-06-20 | 2007-06-20 | Substituierte Oxazolidinone und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6251281A2 true CO6251281A2 (es) | 2011-02-21 |
Family
ID=39731148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09144220A CO6251281A2 (es) | 2007-06-20 | 2009-12-16 | (oxazolidinon-5-il-metil)-2- tiofen-carboxamidas sustituidas y su uso en el campo de la coagulacion sanguinea |
Country Status (43)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006039589A1 (de) * | 2006-08-24 | 2008-03-06 | Bayer Healthcare Ag | Aminoacyl-Prodrugs II |
| DE102007028319A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028407A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102010028362A1 (de) * | 2010-04-29 | 2011-11-03 | Bayer Schering Pharma Aktiengesellschaft | Herstellverfahren |
| CN102464658B (zh) * | 2010-11-03 | 2014-04-16 | 天津药物研究院 | 噁唑烷酮衍生物及其制备方法和用途 |
| CA2824885A1 (en) | 2011-01-19 | 2012-07-26 | Bayer Intellectual Property Gmbh | Binding proteins to inhibitors of coagulation factors |
| CN103626749A (zh) * | 2012-08-21 | 2014-03-12 | 苏州泽璟生物制药有限公司 | 取代的噁唑烷酮化合物和包含该化合物的药物组合物及其用途 |
| CN104163819A (zh) * | 2013-05-17 | 2014-11-26 | 天津药物研究院 | 一种噁唑烷酮衍生物的乙酸溶剂化物及其制备方法和用途 |
| CN103242307B (zh) * | 2013-05-17 | 2015-08-12 | 天津药物研究院有限公司 | 一种噁唑烷酮类衍生物晶型ⅰ及其制备方法和用途 |
| CN103232446B (zh) * | 2013-05-17 | 2015-09-23 | 天津药物研究院 | 一种噁唑烷酮衍生物晶型ⅱ及其制备方法和用途 |
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| DE102007028319A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028407A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028406A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
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2007
- 2007-06-20 DE DE102007028319A patent/DE102007028319A1/de not_active Withdrawn
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2008
- 2008-06-06 UY UY31133A patent/UY31133A1/es not_active Application Discontinuation
- 2008-06-07 DK DK08773372.1T patent/DK2170877T5/da active
- 2008-06-07 NZ NZ581540A patent/NZ581540A/en not_active IP Right Cessation
- 2008-06-07 RS RS20130039A patent/RS52639B/en unknown
- 2008-06-07 PT PT87733721T patent/PT2170877E/pt unknown
- 2008-06-07 KR KR1020097026556A patent/KR101535312B1/ko not_active IP Right Cessation
- 2008-06-07 CN CN2008801031298A patent/CN101821259B/zh not_active Expired - Fee Related
- 2008-06-07 MY MYPI20095462 patent/MY150931A/en unknown
- 2008-06-07 CA CA2692166A patent/CA2692166C/en not_active Expired - Fee Related
- 2008-06-07 BR BRPI0813736-6A2A patent/BRPI0813736A2/pt not_active Application Discontinuation
- 2008-06-07 WO PCT/EP2008/004562 patent/WO2008155032A1/de active Application Filing
- 2008-06-07 JP JP2010512559A patent/JP5537421B2/ja not_active Expired - Fee Related
- 2008-06-07 ES ES08773372T patent/ES2397799T3/es active Active
- 2008-06-07 EP EP08773372A patent/EP2170877B1/de active Active
- 2008-06-07 AU AU2008266525A patent/AU2008266525B8/en not_active Ceased
- 2008-06-07 UA UAA201000550A patent/UA98793C2/ru unknown
- 2008-06-07 SI SI200830882T patent/SI2170877T1/sl unknown
- 2008-06-07 SG SG2012045779A patent/SG182220A1/en unknown
- 2008-06-07 RU RU2010101307/04A patent/RU2481345C2/ru not_active IP Right Cessation
- 2008-06-07 PL PL08773372T patent/PL2170877T3/pl unknown
- 2008-06-07 US US12/665,729 patent/US8383822B2/en not_active Expired - Fee Related
- 2008-06-07 MX MX2009013711A patent/MX2009013711A/es active IP Right Grant
- 2008-06-09 CL CL2008001691A patent/CL2008001691A1/es unknown
- 2008-06-10 PE PE2008000978A patent/PE20090332A1/es not_active Application Discontinuation
- 2008-06-11 PA PA20088784301A patent/PA8784301A1/es unknown
- 2008-06-12 AR ARP080102515A patent/AR066981A1/es not_active Application Discontinuation
- 2008-06-17 JO JO2008282A patent/JO2798B1/en active
- 2008-06-19 TW TW097122783A patent/TWI413642B/zh not_active IP Right Cessation
- 2008-06-19 AR ARP080102607A patent/AR067057A1/es not_active Application Discontinuation
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2009
- 2009-11-26 IL IL202351A patent/IL202351A/en not_active IP Right Cessation
- 2009-11-30 TN TNP2009000503A patent/TN2009000503A1/fr unknown
- 2009-12-15 SV SV2009003435A patent/SV2009003435A/es unknown
- 2009-12-15 HN HN2009003424A patent/HN2009003424A/es unknown
- 2009-12-15 DO DO2009000285A patent/DOP2009000285A/es unknown
- 2009-12-15 CR CR11168A patent/CR11168A/es not_active Application Discontinuation
- 2009-12-15 CU CU20090216A patent/CU23820A3/es active IP Right Grant
- 2009-12-15 GT GT200900319A patent/GT200900319A/es unknown
- 2009-12-15 EC EC2009009807A patent/ECSP099807A/es unknown
- 2009-12-16 CO CO09144220A patent/CO6251281A2/es active IP Right Grant
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2010
- 2010-01-19 MA MA32539A patent/MA31535B1/fr unknown
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2011
- 2011-02-22 HK HK11101717.7A patent/HK1147991A1/xx not_active IP Right Cessation
-
2013
- 2013-01-28 HR HRP20130072AT patent/HRP20130072T1/hr unknown
- 2013-02-01 CY CY20131100095T patent/CY1113580T1/el unknown
- 2013-02-19 US US13/770,270 patent/US8846934B2/en not_active Expired - Fee Related
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