PL1776124T3 - Oligonukleotydy immunomodulujące w skojarzeniu ze środkami chemioterapeutycznymi - Google Patents

Oligonukleotydy immunomodulujące w skojarzeniu ze środkami chemioterapeutycznymi

Info

Publication number
PL1776124T3
PL1776124T3 PL05772724T PL05772724T PL1776124T3 PL 1776124 T3 PL1776124 T3 PL 1776124T3 PL 05772724 T PL05772724 T PL 05772724T PL 05772724 T PL05772724 T PL 05772724T PL 1776124 T3 PL1776124 T3 PL 1776124T3
Authority
PL
Poland
Prior art keywords
connection
immune modulating
modulating oligonucleotides
chemotherapeutic
measures
Prior art date
Application number
PL05772724T
Other languages
English (en)
Inventor
Burghardt Wittig
Manuel Schmidt
Heribert Bohlen
Original Assignee
Mologen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mologen Ag filed Critical Mologen Ag
Publication of PL1776124T3 publication Critical patent/PL1776124T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
PL05772724T 2004-08-09 2005-08-09 Oligonukleotydy immunomodulujące w skojarzeniu ze środkami chemioterapeutycznymi PL1776124T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DE2004/001801 WO2006015560A1 (de) 2004-08-09 2004-08-09 Immunmodulierendes mittel in verbindung mit chemotherapeutischen massnahmen
EP05772724.0A EP1776124B1 (en) 2004-08-09 2005-08-09 Immune modulating oligonucleotides in connection with chemotherapeutic measures

Publications (1)

Publication Number Publication Date
PL1776124T3 true PL1776124T3 (pl) 2017-07-31

Family

ID=34958595

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05772724T PL1776124T3 (pl) 2004-08-09 2005-08-09 Oligonukleotydy immunomodulujące w skojarzeniu ze środkami chemioterapeutycznymi

Country Status (6)

Country Link
US (1) US9212366B2 (pl)
EP (2) EP3202407A1 (pl)
DK (1) DK1776124T3 (pl)
ES (1) ES2621123T3 (pl)
PL (1) PL1776124T3 (pl)
WO (2) WO2006015560A1 (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
DK1716234T3 (da) * 2004-02-20 2014-01-20 Mologen Ag Substitueret, ikke-kodende nukleinsyremolekyle til terapeutisk og profylaktisk immunstimulering i mennesker og højerestående dyr
WO2006015560A1 (de) 2004-08-09 2006-02-16 Mologen Ag Immunmodulierendes mittel in verbindung mit chemotherapeutischen massnahmen
ES2435531T3 (es) 2005-07-01 2013-12-20 Index Pharmaceuticals Ab Modulación de la capacidad de respuesta a los esteroides
JP5074392B2 (ja) 2005-07-01 2012-11-14 インデックス・ファーマシューティカルズ・アクチエボラーグ 免疫促進方法
JP2009513629A (ja) 2005-10-28 2009-04-02 インデックス・ファーマシューティカルズ・アクチエボラーグ 炎症性疾患を予防、処置、および／または緩和する組成物および方法
EP2058397A1 (de) * 2007-11-07 2009-05-13 Mologen AG Multimeres Assemblat zur Immunstimulation
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
EP2246433A1 (de) * 2009-04-30 2010-11-03 Mologen AG Concatemere zur Immunmodulation
GB2514591A (en) * 2013-05-30 2014-12-03 Mologen Ag Predictive biomarker for cancer therapy
JP6697384B2 (ja) 2013-07-25 2020-05-20 イグジキュア, インコーポレーテッドExicure, Inc. 予防的および治療的使用のための免疫刺激剤としての球状の核酸ベース構築物
GB2523187A (en) * 2014-02-18 2015-08-19 Mologen Ag Covalently closed non-coding immunomodulatory DNA construct
TR201908550T4 (tr) 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
US11213593B2 (en) 2014-11-21 2022-01-04 Northwestern University Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
LU92821B1 (en) 2015-09-09 2017-03-20 Mologen Ag Combination comprising immunostimulatory oligonucleotides
GB2542425A (en) * 2015-09-21 2017-03-22 Mologen Ag Means for the treatment of HIV
US11866700B2 (en) 2016-05-06 2024-01-09 Exicure Operating Company Liposomal spherical nucleic acid (SNA) constructs presenting antisense oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor mRNA
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
EP3392345A1 (en) 2017-04-22 2018-10-24 Mologen AG Biomarker for small cell lung cancer therapy
WO2018201090A1 (en) 2017-04-28 2018-11-01 Exicure, Inc. Synthesis of spherical nucleic acids using lipophilic moieties
US11433131B2 (en) 2017-05-11 2022-09-06 Northwestern University Adoptive cell therapy using spherical nucleic acids (SNAs)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6103239A (en) * 1996-08-09 2000-08-15 Cel-Sci Corporation Modified HGP-30 heteroconjugates, compositions and methods of use
DE19935756A1 (de) * 1999-07-27 2001-02-08 Mologen Forschungs Entwicklung Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation
EP1355661A2 (de) * 2001-01-31 2003-10-29 Mologen Forschungs-, Entwicklungs- und Vertriebs GmbH Tumorvakzine
RU2354694C2 (ru) * 2003-12-30 2009-05-10 Мологен Аг Аллогенное противоопухолевое терапевтическое средство
WO2006015560A1 (de) 2004-08-09 2006-02-16 Mologen Ag Immunmodulierendes mittel in verbindung mit chemotherapeutischen massnahmen

Also Published As

Publication number Publication date
WO2006015872A9 (en) 2007-03-29
EP1776124B1 (en) 2017-01-04
WO2006015560A1 (de) 2006-02-16
WO2006015872A1 (en) 2006-02-16
ES2621123T3 (es) 2017-07-03
EP3202407A1 (en) 2017-08-09
DK1776124T3 (en) 2017-04-10
US20090053250A1 (en) 2009-02-26
EP1776124A1 (en) 2007-04-25
US9212366B2 (en) 2015-12-15

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