PL1664315T3 - Wektory aav do terapii genowej in vivo reumatoidalnego zapalenia stawów - Google Patents
Wektory aav do terapii genowej in vivo reumatoidalnego zapalenia stawówInfo
- Publication number
- PL1664315T3 PL1664315T3 PL04774913T PL04774913T PL1664315T3 PL 1664315 T3 PL1664315 T3 PL 1664315T3 PL 04774913 T PL04774913 T PL 04774913T PL 04774913 T PL04774913 T PL 04774913T PL 1664315 T3 PL1664315 T3 PL 1664315T3
- Authority
- PL
- Poland
- Prior art keywords
- gene therapy
- vivo gene
- rheumatoid arthritis
- aav vectors
- virions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL0300611 | 2003-09-01 | ||
PCT/NL2004/000607 WO2005021768A1 (en) | 2003-09-01 | 2004-09-01 | Aav vectors for in vivo gene therapy of rheumatoid arthritis |
EP04774913A EP1664315B1 (en) | 2003-09-01 | 2004-09-01 | Aav vectors for in vivo gene therapy of rheumatoid arthritis |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1664315T3 true PL1664315T3 (pl) | 2012-09-28 |
Family
ID=34270790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL04774913T PL1664315T3 (pl) | 2003-09-01 | 2004-09-01 | Wektory aav do terapii genowej in vivo reumatoidalnego zapalenia stawów |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP1664315B1 (pl) |
JP (1) | JP4863874B2 (pl) |
AT (1) | ATE556140T1 (pl) |
AU (1) | AU2004269279B2 (pl) |
CA (1) | CA2536471C (pl) |
DK (1) | DK1664315T3 (pl) |
ES (1) | ES2384975T3 (pl) |
PL (1) | PL1664315T3 (pl) |
PT (1) | PT1664315E (pl) |
WO (1) | WO2005021768A1 (pl) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090104155A1 (en) * | 2006-04-21 | 2009-04-23 | Goodrich Laurie R | Treatment of connective tissue disorders |
CN118048321A (zh) | 2016-01-13 | 2024-05-17 | 建新公司 | 用于治疗哺乳动物内骨关节炎和相关关节病症的表达骨保护性基因、包括has2和润滑素的重组aav载体 |
HUE062774T2 (hu) * | 2018-01-17 | 2023-12-28 | Meiragtx Uk Ii Ltd | Módosított rAAV kapszidfehérje génterápiához |
WO2023183623A1 (en) | 2022-03-25 | 2023-09-28 | Regenxbio Inc. | Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US5952221A (en) | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
US6046319A (en) | 1997-10-22 | 2000-04-04 | University Technologies International, Inc. | Antisense oligodeoxynucleotides regulating expression of TNF-α |
ATE402254T1 (de) * | 1998-05-28 | 2008-08-15 | Us Gov Health & Human Serv | Aav5 vektoren und deren verwendung |
CA2374597A1 (en) * | 1999-05-28 | 2000-12-07 | Targeted Genetics Corporation | Methods and compositions for lowering the level of tumor necrosis factor (tnf) in the tnf-associated disorders |
JP4827353B2 (ja) * | 1999-08-09 | 2011-11-30 | ターゲティッド ジェネティクス コーポレイション | 鎖内塩基対を形成するような配列の設計による、組換えウイルスベクターからの一本鎖の異種ヌクレオチド配列の発現の増大 |
US20040191221A1 (en) * | 2001-05-22 | 2004-09-30 | Keiya Ozawa | Methods of treating skeletal disorders using recombinant adeno-associated virus virions |
US20030003583A1 (en) * | 2001-06-08 | 2003-01-02 | Raphael Hirsch | Regulation of transgene expression following AAV transduction |
WO2003093440A2 (en) * | 2002-04-30 | 2003-11-13 | University Of Florida | Methods and compositions for expressing a nucleic acid in a dendritic cell |
-
2004
- 2004-09-01 EP EP04774913A patent/EP1664315B1/en active Active
- 2004-09-01 AU AU2004269279A patent/AU2004269279B2/en active Active
- 2004-09-01 JP JP2006525289A patent/JP4863874B2/ja active Active
- 2004-09-01 PL PL04774913T patent/PL1664315T3/pl unknown
- 2004-09-01 CA CA2536471A patent/CA2536471C/en active Active
- 2004-09-01 AT AT04774913T patent/ATE556140T1/de active
- 2004-09-01 DK DK04774913.0T patent/DK1664315T3/da active
- 2004-09-01 WO PCT/NL2004/000607 patent/WO2005021768A1/en active Application Filing
- 2004-09-01 PT PT04774913T patent/PT1664315E/pt unknown
- 2004-09-01 ES ES04774913T patent/ES2384975T3/es active Active
- 2004-09-01 EP EP10175639A patent/EP2322638A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
PT1664315E (pt) | 2012-07-31 |
DK1664315T3 (da) | 2012-07-09 |
AU2004269279B2 (en) | 2010-02-25 |
JP4863874B2 (ja) | 2012-01-25 |
CA2536471A1 (en) | 2005-03-10 |
EP1664315A1 (en) | 2006-06-07 |
ES2384975T3 (es) | 2012-07-16 |
WO2005021768A1 (en) | 2005-03-10 |
EP2322638A1 (en) | 2011-05-18 |
ATE556140T1 (de) | 2012-05-15 |
EP1664315B1 (en) | 2012-05-02 |
CA2536471C (en) | 2013-10-08 |
JP2007504219A (ja) | 2007-03-01 |
AU2004269279A1 (en) | 2005-03-10 |
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