ATE556140T1 - Aav vektoren für die gentherapie von rheumatischer arthritis - Google Patents
Aav vektoren für die gentherapie von rheumatischer arthritisInfo
- Publication number
- ATE556140T1 ATE556140T1 AT04774913T AT04774913T ATE556140T1 AT E556140 T1 ATE556140 T1 AT E556140T1 AT 04774913 T AT04774913 T AT 04774913T AT 04774913 T AT04774913 T AT 04774913T AT E556140 T1 ATE556140 T1 AT E556140T1
- Authority
- AT
- Austria
- Prior art keywords
- gene therapy
- aav vectors
- rheumatic arthritis
- virions
- aav
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL0300611 | 2003-09-01 | ||
| PCT/NL2004/000607 WO2005021768A1 (en) | 2003-09-01 | 2004-09-01 | Aav vectors for in vivo gene therapy of rheumatoid arthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE556140T1 true ATE556140T1 (de) | 2012-05-15 |
Family
ID=34270790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04774913T ATE556140T1 (de) | 2003-09-01 | 2004-09-01 | Aav vektoren für die gentherapie von rheumatischer arthritis |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP2322638A1 (de) |
| JP (1) | JP4863874B2 (de) |
| AT (1) | ATE556140T1 (de) |
| AU (1) | AU2004269279B2 (de) |
| CA (1) | CA2536471C (de) |
| DK (1) | DK1664315T3 (de) |
| ES (1) | ES2384975T3 (de) |
| PL (1) | PL1664315T3 (de) |
| PT (1) | PT1664315E (de) |
| WO (1) | WO2005021768A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2037943A4 (de) * | 2006-04-21 | 2010-03-31 | Univ North Carolina | Behandlung von bindegewebeerkrankungen |
| WO2017123934A1 (en) | 2016-01-13 | 2017-07-20 | Merial, Inc. | Recombinant aav vectors expressing osteoprotective genes, including has2 and lubricin, useful in the treatment of osteoarthritis and related joint conditions in mammals |
| PL3740222T3 (pl) * | 2018-01-17 | 2023-12-04 | Meiragtx Uk Ii Limited | Zmodyfikowane białko kapsydu raav do terapii genowej |
| WO2023183623A1 (en) | 2022-03-25 | 2023-09-28 | Regenxbio Inc. | Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US5952221A (en) | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
| CA2248762A1 (en) | 1997-10-22 | 1999-04-22 | University Technologies International, Inc. | Antisense oligodeoxynucleotides regulating expression of tnf-.alpha. |
| ES2313784T3 (es) * | 1998-05-28 | 2009-03-01 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Vector aav5 y usos del mismo. |
| PT1180159E (pt) * | 1999-05-28 | 2008-12-05 | Targeted Genetics Corp | Métodos e composições para abaixamento do nível de factor de necrose tumoral (tnf) nos distúrbios associados a tnf |
| EP2369002A1 (de) * | 1999-08-09 | 2011-09-28 | Targeted Genetics Corporation | Erweiterte Expression einer einstämmigen, heterologen Nukleotidsequenz von rekombinanten viralen Vektoren durch Modellierung der Sequenz mit stammübergreifenden Basispaaren |
| US20040191221A1 (en) * | 2001-05-22 | 2004-09-30 | Keiya Ozawa | Methods of treating skeletal disorders using recombinant adeno-associated virus virions |
| US20030003583A1 (en) * | 2001-06-08 | 2003-01-02 | Raphael Hirsch | Regulation of transgene expression following AAV transduction |
| AU2003231281A1 (en) * | 2002-04-30 | 2003-11-17 | University Of Florida | Methods and compositions for expressing a nucleic acid in a dendritic cell |
-
2004
- 2004-09-01 WO PCT/NL2004/000607 patent/WO2005021768A1/en active Application Filing
- 2004-09-01 DK DK04774913.0T patent/DK1664315T3/da active
- 2004-09-01 EP EP10175639A patent/EP2322638A1/de not_active Withdrawn
- 2004-09-01 EP EP04774913A patent/EP1664315B1/de active Active
- 2004-09-01 CA CA2536471A patent/CA2536471C/en active Active
- 2004-09-01 AU AU2004269279A patent/AU2004269279B2/en active Active
- 2004-09-01 PL PL04774913T patent/PL1664315T3/pl unknown
- 2004-09-01 PT PT04774913T patent/PT1664315E/pt unknown
- 2004-09-01 ES ES04774913T patent/ES2384975T3/es active Active
- 2004-09-01 JP JP2006525289A patent/JP4863874B2/ja active Active
- 2004-09-01 AT AT04774913T patent/ATE556140T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2536471C (en) | 2013-10-08 |
| ES2384975T3 (es) | 2012-07-16 |
| JP2007504219A (ja) | 2007-03-01 |
| AU2004269279A1 (en) | 2005-03-10 |
| JP4863874B2 (ja) | 2012-01-25 |
| WO2005021768A1 (en) | 2005-03-10 |
| DK1664315T3 (da) | 2012-07-09 |
| EP2322638A1 (de) | 2011-05-18 |
| EP1664315B1 (de) | 2012-05-02 |
| CA2536471A1 (en) | 2005-03-10 |
| AU2004269279B2 (en) | 2010-02-25 |
| EP1664315A1 (de) | 2006-06-07 |
| PL1664315T3 (pl) | 2012-09-28 |
| PT1664315E (pt) | 2012-07-31 |
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