PL1636215T3 - Furazanobenzymidazole - Google Patents
FurazanobenzymidazoleInfo
- Publication number
- PL1636215T3 PL1636215T3 PL04733874T PL04733874T PL1636215T3 PL 1636215 T3 PL1636215 T3 PL 1636215T3 PL 04733874 T PL04733874 T PL 04733874T PL 04733874 T PL04733874 T PL 04733874T PL 1636215 T3 PL1636215 T3 PL 1636215T3
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- formula
- carbonyl group
- neoplastic
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03405365 | 2003-05-23 | ||
| EP04733874A EP1636215B1 (en) | 2003-05-23 | 2004-05-19 | Furazanobenzimidazoles |
| PCT/IB2004/001723 WO2004103994A1 (en) | 2003-05-23 | 2004-05-19 | Furazanobenzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1636215T3 true PL1636215T3 (pl) | 2008-09-30 |
Family
ID=33462273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04733874T PL1636215T3 (pl) | 2003-05-23 | 2004-05-19 | Furazanobenzymidazole |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | USRE42890E1 (pl) |
| EP (1) | EP1636215B1 (pl) |
| JP (2) | JP4829791B2 (pl) |
| CN (1) | CN100434428C (pl) |
| AT (1) | ATE384718T1 (pl) |
| CA (1) | CA2526026C (pl) |
| CY (1) | CY1107422T1 (pl) |
| DE (1) | DE602004011515T2 (pl) |
| DK (1) | DK1636215T3 (pl) |
| ES (1) | ES2300775T3 (pl) |
| PL (1) | PL1636215T3 (pl) |
| PT (1) | PT1636215E (pl) |
| SI (1) | SI1636215T1 (pl) |
| WO (1) | WO2004103994A1 (pl) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG159380A1 (en) * | 2002-02-06 | 2010-03-30 | Vertex Pharma | Heteroaryl compounds useful as inhibitors of gsk-3 |
| DK1723138T3 (da) * | 2004-02-11 | 2010-08-23 | Basilea Pharmaceutica Ag | Substituerede benzimidazoler og deres anvendelse til at inducere apoptose |
| US7625890B2 (en) | 2005-11-10 | 2009-12-01 | Smithkline Beecham Corp. | Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors |
| EA021380B1 (ru) * | 2009-07-27 | 2015-06-30 | Базилеа Фармацойтика Аг | Фуразанобензимидазолы в качестве пролекарств для лечения опухолевых или аутоиммунных заболеваний |
| HUE031162T2 (en) | 2011-01-21 | 2017-07-28 | Basilea Pharmaceutica Ag | Use of Glu tubulin as a biomarker for drug response to furazanobenzimidazoles |
| PL2666015T3 (pl) | 2011-01-21 | 2017-06-30 | Basilea Pharmaceutica Ag | Zastosowanie statminy jako biomarkera odpowiedzi lekowej na furazanobenzoimidazole |
| CA2822491C (en) * | 2011-01-21 | 2023-02-14 | Basilea Pharmaceutica Ag | Bubr1 as a biomarker for furazanobenzimidazoles |
| WO2012113802A1 (en) * | 2011-02-24 | 2012-08-30 | Basilea Pharmaceutica Ag | Use of acetylated tubulin as a biomarker of drug response to furazanobenzimidazoles |
| ES2627972T3 (es) * | 2011-03-29 | 2017-08-01 | Basilea Pharmaceutica Ag | Uso de fosfo-Akt como un biomarcador de la respuesta a fármacos |
| US20180306790A1 (en) * | 2015-10-22 | 2018-10-25 | Basilea Pharmaceutica International AG | Use of eb1 as a biomarker of drug response |
| CN110536890B (zh) | 2017-04-26 | 2023-08-15 | 巴斯利尔药物国际股份公司 | 制备呋咱并苯并咪唑及其晶型的方法 |
| CA3061429A1 (en) | 2017-05-05 | 2018-11-08 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases |
| WO2018210868A1 (en) | 2017-05-16 | 2018-11-22 | Basilea Pharmaceutica International AG | Novel dosage principle for drugs useful for treating neoplastic diseases |
| US11419856B2 (en) | 2017-11-20 | 2022-08-23 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| US20220031670A1 (en) | 2018-09-20 | 2022-02-03 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| US20220370418A1 (en) | 2019-09-09 | 2022-11-24 | Basilea Pharmaceutica International AG | Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases |
| CN111454254B (zh) | 2020-04-26 | 2023-06-02 | 云白药征武科技(上海)有限公司 | 一种具有含氟取代基的苯并咪唑衍生物的制备及其应用 |
| CN111423429A (zh) * | 2020-05-19 | 2020-07-17 | 江西科技师范大学 | 苯并咪唑联呋咱类系列化合物及其合成方法 |
| WO2022053549A1 (en) | 2020-09-10 | 2022-03-17 | Basilea Pharmaceutica International AG | Use of c-myc as a biomarker of drug response |
| GB202101734D0 (en) * | 2021-02-08 | 2021-03-24 | Cerevance Inc | Novel Compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4269846A (en) * | 1979-10-29 | 1981-05-26 | Usv Pharmaceutical Corporation | Heterocyclic compounds useful as anti-allergy agents |
| DE3100771A1 (de) * | 1981-01-13 | 1982-08-26 | USV Pharmaceutical Corp., Tuckahoe, N.Y. | Heterocyclische verbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| DE4307105A1 (de) * | 1993-03-06 | 1994-09-08 | Cassella Ag | Hydroxymethylfurazancarbonsäurederivate |
| US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
| SG159380A1 (en) * | 2002-02-06 | 2010-03-30 | Vertex Pharma | Heteroaryl compounds useful as inhibitors of gsk-3 |
| CL2003002353A1 (es) | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
-
2004
- 2004-05-19 PT PT04733874T patent/PT1636215E/pt unknown
- 2004-05-19 DK DK04733874T patent/DK1636215T3/da active
- 2004-05-19 DE DE602004011515T patent/DE602004011515T2/de not_active Expired - Lifetime
- 2004-05-19 US US12/796,135 patent/USRE42890E1/en not_active Expired - Lifetime
- 2004-05-19 AT AT04733874T patent/ATE384718T1/de active
- 2004-05-19 US US10/557,539 patent/US7385061B2/en not_active Ceased
- 2004-05-19 EP EP04733874A patent/EP1636215B1/en not_active Expired - Lifetime
- 2004-05-19 JP JP2006530690A patent/JP4829791B2/ja not_active Expired - Lifetime
- 2004-05-19 CA CA2526026A patent/CA2526026C/en not_active Expired - Lifetime
- 2004-05-19 SI SI200430636T patent/SI1636215T1/sl unknown
- 2004-05-19 ES ES04733874T patent/ES2300775T3/es not_active Expired - Lifetime
- 2004-05-19 WO PCT/IB2004/001723 patent/WO2004103994A1/en active IP Right Grant
- 2004-05-19 PL PL04733874T patent/PL1636215T3/pl unknown
- 2004-05-19 CN CNB2004800177608A patent/CN100434428C/zh not_active Expired - Fee Related
-
2008
- 2008-04-23 CY CY20081100454T patent/CY1107422T1/el unknown
-
2011
- 2011-06-21 JP JP2011137578A patent/JP5670266B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK1636215T3 (da) | 2008-06-02 |
| US20070043061A1 (en) | 2007-02-22 |
| EP1636215A1 (en) | 2006-03-22 |
| ATE384718T1 (de) | 2008-02-15 |
| CN100434428C (zh) | 2008-11-19 |
| WO2004103994A1 (en) | 2004-12-02 |
| ES2300775T3 (es) | 2008-06-16 |
| CA2526026A1 (en) | 2004-12-02 |
| SI1636215T1 (sl) | 2008-06-30 |
| US7385061B2 (en) | 2008-06-10 |
| DE602004011515T2 (de) | 2009-01-29 |
| JP2006528238A (ja) | 2006-12-14 |
| JP5670266B2 (ja) | 2015-02-18 |
| DE602004011515D1 (de) | 2008-03-13 |
| JP4829791B2 (ja) | 2011-12-07 |
| CY1107422T1 (el) | 2012-12-19 |
| JP2011207909A (ja) | 2011-10-20 |
| EP1636215B1 (en) | 2008-01-23 |
| CN1812986A (zh) | 2006-08-02 |
| PT1636215E (pt) | 2008-04-29 |
| CA2526026C (en) | 2012-03-20 |
| USRE42890E1 (en) | 2011-11-01 |
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