PH30988A - Antimigraine-4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines. - Google Patents

Antimigraine-4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines.

Info

Publication number
PH30988A
PH30988A PH45427A PH45427A PH30988A PH 30988 A PH30988 A PH 30988A PH 45427 A PH45427 A PH 45427A PH 45427 A PH45427 A PH 45427A PH 30988 A PH30988 A PH 30988A
Authority
PH
Philippines
Prior art keywords
antimigraine
indol
pyrimidinyl
alkyl piperazines
pyridinyl derivatives
Prior art date
Application number
PH45427A
Other languages
English (en)
Inventor
David W Smith
Joseph P Yevich
Williams Andrew
Edward H Ruediger
Combrink Keith Dean
Pearce Bradley Clyde
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PH30988A publication Critical patent/PH30988A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
PH45427A 1991-12-19 1992-12-15 Antimigraine-4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines. PH30988A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81066191A 1991-12-19 1991-12-19
US95959292A 1992-10-13 1992-10-13

Publications (1)

Publication Number Publication Date
PH30988A true PH30988A (en) 1997-12-23

Family

ID=27123378

Family Applications (1)

Application Number Title Priority Date Filing Date
PH45427A PH30988A (en) 1991-12-19 1992-12-15 Antimigraine-4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines.

Country Status (15)

Country Link
US (1) US5434154A (Sortimente)
EP (1) EP0548813A1 (Sortimente)
JP (1) JPH05262762A (Sortimente)
CN (1) CN1085556A (Sortimente)
AU (1) AU661527B2 (Sortimente)
CA (1) CA2084531A1 (Sortimente)
CZ (1) CZ359292A3 (Sortimente)
FI (1) FI925737L (Sortimente)
IL (1) IL104024A (Sortimente)
MX (1) MX9207114A (Sortimente)
NO (1) NO302522B1 (Sortimente)
NZ (1) NZ245439A (Sortimente)
PH (1) PH30988A (Sortimente)
RU (1) RU2114111C1 (Sortimente)
TW (1) TW221420B (Sortimente)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521188A (en) * 1993-09-16 1996-05-28 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
CA2130078A1 (en) * 1993-09-16 1995-03-17 Jonas A. Gylys Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
JPH10501212A (ja) * 1994-05-19 1998-02-03 メルク シヤープ エンド ドーム リミテツド ５−ｈｔ▲下１ｄ▼−アルファ作働薬としてのインドール−３−イルアルキルのピペラジン、ピペリジンおよびテトラヒドロピリジン誘導体
GB9410031D0 (en) * 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents
US5552402A (en) * 1994-05-19 1996-09-03 Merck, Sharp & Dohme Ltd. Five-membered heteroaromatic compounds as 5-HT receptor agonists
US5567824A (en) * 1994-05-24 1996-10-22 Merck & Co., Inc. Palladium catalyzed ring closure of triazolyltryptamine
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents
US5550239A (en) * 1994-11-08 1996-08-27 Bristol-Myers Squibb Company Process for large-scale production of indolyl alkyl pyrimidinyl piperazine compounds
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
CA2228286A1 (en) * 1995-08-07 1997-02-20 Merck Sharp & Dohme Limited Substituted 1-indolylpropyl-4-phenethylpiperazine derivatives
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
GB9519563D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
EP0854714A1 (en) * 1995-09-28 1998-07-29 MERCK SHARP & DOHME LTD. Substituted indolylpropyl-piperazine derivatives as 5-ht 1dalpha? agonists
US5998415A (en) * 1995-11-02 1999-12-07 Merck Sharp & Dohme Ltd. Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors
GB9523250D0 (en) * 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents
GB9609374D0 (en) * 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
US5877329A (en) * 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
US5811551A (en) * 1996-08-13 1998-09-22 Merck & Co., Inc. Palladium catalyzed indolization
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
DE19756036A1 (de) 1997-12-17 1999-06-24 Merck Patent Gmbh Amid- und Harnstoffderivate
JP2004517081A (ja) * 2000-11-29 2004-06-10 イーライ・リリー・アンド・カンパニー １−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物
DE10102944A1 (de) * 2001-01-23 2002-07-25 Merck Patent Gmbh Verfahren zur Herstellung von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon und dessen Salzen
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
DE60233076D1 (de) 2002-02-13 2009-09-03 Meiji Dairies Corp Indolderivate substituiert mit langkettigen alcoholen und sie enthaltende arzneimittel
DE102004047517A1 (de) * 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
WO2006129190A1 (en) * 2005-06-03 2006-12-07 Glenmark Pharmaceuticals Limited Process for the preparation of almotriptan
RU2461556C2 (ru) * 2006-12-30 2012-09-20 Эбботт Гмбх Унд Ко. Кг Замещенные производные оксидола и их применение в качестве лигандов рецептора вазопрессина
ES2538082T3 (es) 2007-02-11 2015-06-17 Map Pharmaceuticals Inc Método de administración terapéutica de DHE para permitir el rápido alivio de migraña mientras que se minimiza el perfil de efectos secundarios
EP2036888A1 (en) * 2007-09-17 2009-03-18 Laboratorios del Dr. Esteve S.A. Naphthyl-substituted sulfonamides
ES2751388T3 (es) 2011-07-22 2020-03-31 Univ Chicago IGF-1 para su uso en el tratamiento de la jaqueca
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions
CN104163813B (zh) * 2013-05-16 2017-02-01 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
CN104725363B (zh) * 2013-12-20 2019-03-01 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
US9714232B2 (en) * 2013-12-20 2017-07-25 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
CN106243088B (zh) * 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
WO2019082143A1 (en) * 2017-10-27 2019-05-02 Fresenius Kabi Oncology Ltd. IMPROVED PROCESS FOR THE PREPARATION OF RIBOCICLIB AND ITS SALTS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (Sortimente) * 1959-09-25 1900-01-01
GB1189064A (en) 1967-05-01 1970-04-22 Sterling Drug Inc Indole Derivatives
GR79215B (Sortimente) 1982-06-07 1984-10-22 Glaxo Group Ltd
GB2162522B (en) 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
FR2635104B1 (fr) 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
JP2871811B2 (ja) 1990-02-28 1999-03-17 サントリー株式会社 縮合７員環系化合物
US5077293A (en) 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives

Also Published As

Publication number Publication date
CN1085556A (zh) 1994-04-20
JPH05262762A (ja) 1993-10-12
RU2114111C1 (ru) 1998-06-27
AU3003492A (en) 1994-03-24
NZ245439A (en) 1995-07-26
FI925737A0 (fi) 1992-12-17
CZ359292A3 (en) 1994-01-19
FI925737A7 (fi) 1993-06-20
FI925737L (fi) 1993-06-20
US5434154A (en) 1995-07-18
MX9207114A (es) 1993-07-01
IL104024A (en) 1997-04-15
CA2084531A1 (en) 1993-06-20
TW221420B (Sortimente) 1994-03-01
AU661527B2 (en) 1995-07-27
EP0548813A1 (en) 1993-06-30
NO924764L (no) 1993-06-21
NO302522B1 (no) 1998-03-16
NO924764D0 (no) 1992-12-10

Similar Documents

Publication Publication Date Title
PH30988A (en) Antimigraine-4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines.
GR3023258T3 (en) 3-Aryl-4-hydroxy-delta3-dihydrofuranone and 3-aryl-4-hydroxy-delta3-dihydrothiophenone derivatives
AU650989B2 (en) Amino-substituted piperazine derivatives
IL101865A0 (en) Thiopyranopyrrole derivatives and their preparation
NZ241376A (en) 1-(4-alkane-sulphinyl-, -sulphenyl-, and
EP0498268A3 (en) 5-oxo-l-proline derivatives and pharmaceutical use thereof
ZA921279B (en) Substituted alpha-aminoaldehydes and derivatives
NZ231487A (en) Pyridin-2-yl piperazine derivatives and pharmaceutical compositions
PH31162A (en) Piperazine derivatives and salts thereof.
ZA927172B (en) Heterocyclic compounds and their preparation and use.
EP0482649A3 (en) Cm-chitin derivatives and use thereof
ZA929770B (en) Heterocyclic compounds and their preparation and use
ZA926189B (en) Beta-Phenylisoserine derivatives and their preparation and use.
IL101444A0 (en) Tetronic and thiotetronic acid derivatives
HU9203730D0 (en) Substituted phthalides and heterocyclic ones
HU9303025D0 (en) 4-aryl-3(jheteroaryl-ureido)-quinoline derivatives and pharmaceutical preparatives containing them
ZA928893B (en) 3-Pyridinol derivatives and their use as medicaments
NZ238428A (en) Cephalosporin derivatives and medicaments
GB2257430B (en) Piperazine derivatives
ZA932602B (en) Piperazine derivatives
GB9321688D0 (en) Piperazine derivatives
EP0553772A3 (en) Bed and spring-mattress
ZA929445B (en) Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines.
GB2286392B (en) Piperazine derivatives and pharmaceutical uses thereof
NZ248041A (en) Aminoalkyl- tetrahydrofuran derivatives and medicaments