TW221420B - - Google Patents

Info

Publication number
TW221420B
TW221420B TW081110009A TW81110009A TW221420B TW 221420 B TW221420 B TW 221420B TW 081110009 A TW081110009 A TW 081110009A TW 81110009 A TW81110009 A TW 81110009A TW 221420 B TW221420 B TW 221420B
Authority
TW
Taiwan
Application number
TW081110009A
Inventor
Bradley C Pearce
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of TW221420B publication Critical patent/TW221420B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
TW081110009A 1991-12-19 1992-12-14 TW221420B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81066191A 1991-12-19 1991-12-19
US95959292A 1992-10-13 1992-10-13

Publications (1)

Publication Number Publication Date
TW221420B true TW221420B (zh) 1994-03-01

Family

ID=27123378

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081110009A TW221420B (zh) 1991-12-19 1992-12-14

Country Status (15)

Country Link
US (1) US5434154A (zh)
EP (1) EP0548813A1 (zh)
JP (1) JPH05262762A (zh)
CN (1) CN1085556A (zh)
AU (1) AU661527B2 (zh)
CA (1) CA2084531A1 (zh)
CZ (1) CZ359292A3 (zh)
FI (1) FI925737A (zh)
IL (1) IL104024A (zh)
MX (1) MX9207114A (zh)
NO (1) NO302522B1 (zh)
NZ (1) NZ245439A (zh)
PH (1) PH30988A (zh)
RU (1) RU2114111C1 (zh)
TW (1) TW221420B (zh)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521188A (en) * 1993-09-16 1996-05-28 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
CA2130078A1 (en) * 1993-09-16 1995-03-17 Jonas A. Gylys Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9410031D0 (en) * 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents
CA2190501A1 (en) * 1994-05-19 1995-11-30 Jose Luis Castro Pineiro Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists
US5552402A (en) * 1994-05-19 1996-09-03 Merck, Sharp & Dohme Ltd. Five-membered heteroaromatic compounds as 5-HT receptor agonists
US5567824A (en) * 1994-05-24 1996-10-22 Merck & Co., Inc. Palladium catalyzed ring closure of triazolyltryptamine
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents
US5550239A (en) * 1994-11-08 1996-08-27 Bristol-Myers Squibb Company Process for large-scale production of indolyl alkyl pyrimidinyl piperazine compounds
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
EP0844996A1 (en) * 1995-08-07 1998-06-03 MERCK SHARP & DOHME LTD. Substituted 1-indolylpropyl-4-phenethylpiperazine derivatives
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
GB9519563D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
EP0854714A1 (en) * 1995-09-28 1998-07-29 MERCK SHARP & DOHME LTD. Substituted indolylpropyl-piperazine derivatives as 5-ht 1dalpha? agonists
US5998415A (en) * 1995-11-02 1999-12-07 Merck Sharp & Dohme Ltd. Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors
GB9523250D0 (en) * 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents
GB9609374D0 (en) * 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
US5811551A (en) * 1996-08-13 1998-09-22 Merck & Co., Inc. Palladium catalyzed indolization
US5877329A (en) * 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
DE19756036A1 (de) * 1997-12-17 1999-06-24 Merck Patent Gmbh Amid- und Harnstoffderivate
DE60130677T2 (de) * 2000-11-29 2008-07-17 Eli Lilly And Co., Indianapolis 1-(2-m-methansulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine und ihre akzeptablen pharmazeutischen salze und solvate und ihre verwendung zur behandlung von inkontinenz
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
EP1474390B1 (en) * 2002-02-13 2009-07-22 Meiji Dairies Corporation Indole derivatives substituted with long-chain alcohols and medicaments containing them
WO2006129190A1 (en) * 2005-06-03 2006-12-07 Glenmark Pharmaceuticals Limited Process for the preparation of almotriptan
RU2461556C2 (ru) * 2006-12-30 2012-09-20 Эбботт Гмбх Унд Ко. Кг Замещенные производные оксидола и их применение в качестве лигандов рецептора вазопрессина
KR20090129998A (ko) 2007-02-11 2009-12-17 맵 파마슈티컬스, 인코포레이티드 부작용 프로파일을 최소화하면서 편두통의 빠른 완화를 가능하게 하는 ｄｈｅ의 치료적 투여 방법
EP2036888A1 (en) * 2007-09-17 2009-03-18 Laboratorios del Dr. Esteve S.A. Naphthyl-substituted sulfonamides
PL2734634T3 (pl) 2011-07-22 2020-03-31 The University Of Chicago Igf-1 do zastosowania do leczenia migreny
EP2935280A4 (en) 2012-12-21 2016-05-25 Map Pharmaceuticals Inc 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS
CN104163813B (zh) * 2013-05-16 2017-02-01 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
CN104725363B (zh) * 2013-12-20 2019-03-01 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN104725359B (zh) * 2013-12-20 2017-05-03 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN106243088B (zh) * 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
AU2018354972B2 (en) * 2017-10-27 2021-07-08 Fresenius Kabi Oncology Ltd. An improved process for the preparation of ribociclib and its salts

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (zh) * 1959-09-25 1900-01-01
GB1189064A (en) 1967-05-01 1970-04-22 Sterling Drug Inc Indole Derivatives
GR79215B (zh) 1982-06-07 1984-10-22 Glaxo Group Ltd
GB2162522B (en) 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
FR2635104B1 (fr) 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
JP2871811B2 (ja) 1990-02-28 1999-03-17 サントリー株式会社 縮合７員環系化合物
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
US5077293A (en) 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines

Also Published As

Publication number Publication date
FI925737A0 (fi) 1992-12-17
CZ359292A3 (en) 1994-01-19
AU3003492A (en) 1994-03-24
NO924764D0 (no) 1992-12-10
MX9207114A (es) 1993-07-01
US5434154A (en) 1995-07-18
CA2084531A1 (en) 1993-06-20
IL104024A (en) 1997-04-15
NO302522B1 (no) 1998-03-16
NO924764L (no) 1993-06-21
AU661527B2 (en) 1995-07-27
PH30988A (en) 1997-12-23
NZ245439A (en) 1995-07-26
EP0548813A1 (en) 1993-06-30
JPH05262762A (ja) 1993-10-12
RU2114111C1 (ru) 1998-06-27
FI925737A (fi) 1993-06-20
CN1085556A (zh) 1994-04-20

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