|
IL112235A
(en)
*
|
1994-01-03 |
2000-06-29 |
Acea Pharm Inc |
1,4-dihydro-pyrido¬2,3-b¾pyrazine-2,3-dione (5 or 8) oxide derivatives and pharmaceutical compositions containing them
|
|
US5801183A
(en)
*
|
1995-01-27 |
1998-09-01 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists
|
|
US5646130A
(en)
*
|
1995-06-30 |
1997-07-08 |
Ocean University Of Oingdao |
Low molecular weight sulfated polysaccharides and uses thereof
|
|
ZA973884B
(en)
*
|
1996-05-23 |
1998-11-06 |
Du Pont Merck Pharma |
Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
|
|
ATE264093T1
(de)
|
1998-07-16 |
2004-04-15 |
Aaron Tabor |
Sojazubereitungen und deren verwendung zur gesundheitsförderung
|
|
US6930101B1
(en)
|
1999-05-17 |
2005-08-16 |
The Regents Of The University Of California |
Thiazolopyrimidines useful as TNFα inhibitors
|
|
AU2003220401A1
(en)
|
2002-03-18 |
2003-10-08 |
Bristol-Myers Squibb Company |
Uracil derivatives as inhibitors of tnf-alpha converting enzyme (tace) and matrix metalloproteinases
|
|
US6861422B2
(en)
*
|
2003-02-26 |
2005-03-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
|
PT1636228E
(pt)
*
|
2003-05-23 |
2009-02-02 |
Aeterna Zentaris Gmbh |
Novas piridopirazinas e sua utilização como moduladores de cinases
|
|
DE10323345A1
(de)
*
|
2003-05-23 |
2004-12-16 |
Zentaris Gmbh |
Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren
|
|
MY147767A
(en)
*
|
2004-06-16 |
2013-01-31 |
Janssen Pharmaceutica Nv |
Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
|
|
DE102004029784A1
(de)
|
2004-06-21 |
2006-01-05 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004033670A1
(de)
*
|
2004-07-09 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
|
|
US20060074088A1
(en)
*
|
2004-08-14 |
2006-04-06 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones for the treatment of cancer diseases
|
|
US20060035903A1
(en)
*
|
2004-08-14 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Storage stable perfusion solution for dihydropteridinones
|
|
US20060058311A1
(en)
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
|
US7759485B2
(en)
*
|
2004-08-14 |
2010-07-20 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of dihydropteridinones
|
|
US7728134B2
(en)
*
|
2004-08-14 |
2010-06-01 |
Boehringer Ingelheim International Gmbh |
Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
|
|
EP1632493A1
(de)
*
|
2004-08-25 |
2006-03-08 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
|
EP1630163A1
(de)
*
|
2004-08-25 |
2006-03-01 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004058337A1
(de)
*
|
2004-12-02 |
2006-06-14 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
|
|
US7439358B2
(en)
|
2006-02-08 |
2008-10-21 |
Boehringer Ingelheim International Gmbh |
Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
|
|
WO2007122466A1
(en)
*
|
2006-04-21 |
2007-11-01 |
Pfizer Products Inc. |
Pyridine[3,4-b]pyrazinones
|
|
US7601716B2
(en)
*
|
2006-05-01 |
2009-10-13 |
Cephalon, Inc. |
Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
|
|
GB0614471D0
(en)
*
|
2006-07-20 |
2006-08-30 |
Syngenta Ltd |
Herbicidal Compounds
|
|
ZA200902384B
(en)
*
|
2006-10-19 |
2010-07-28 |
Signal Pharm Llc |
Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
|
|
MX2009004077A
(es)
|
2006-10-19 |
2009-05-05 |
Signal Pharm Llc |
Compuestos de heteroarilo, composiciones de los mismos, y su uso como inhibidores de proteina cinasas.
|
|
US8372114B2
(en)
*
|
2006-11-13 |
2013-02-12 |
Electroformed Stents, Inc. |
Over-the-wire exclusion device and system for delivery
|
|
EP2185559A1
(en)
*
|
2007-08-03 |
2010-05-19 |
Boehringer Ingelheim International GmbH |
Crystalline form of a dihydropteridione derivative
|
|
US8110578B2
(en)
*
|
2008-10-27 |
2012-02-07 |
Signal Pharmaceuticals, Llc |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
|
|
EA026557B1
(ru)
|
2008-12-09 |
2017-04-28 |
Джилид Сайэнс, Инк. |
Промежуточные соединения для получения модуляторов толл-подобных рецепторов
|
|
CN102341394B
(zh)
|
2009-01-23 |
2015-04-15 |
武田药品工业株式会社 |
聚(adp-核糖)聚合酶(parp)抑制剂
|
|
JP5715625B2
(ja)
|
2009-07-30 |
2015-05-07 |
武田薬品工業株式会社 |
ポリ(adp−リボース)ポリメラーゼ(parp)阻害剤
|
|
CA2772253C
(en)
*
|
2009-09-14 |
2018-02-27 |
Gilead Sciences, Inc. |
Modulators of toll-like receptors
|
|
JP2013508456A
(ja)
*
|
2009-10-26 |
2013-03-07 |
シグナル ファーマシューティカルズ, エルエルシー |
ヘテロアリール化合物の合成方法および精製方法
|
|
EP2992878A1
(en)
*
|
2010-02-03 |
2016-03-09 |
Signal Pharmaceuticals, LLC |
Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors
|
|
US8546566B2
(en)
|
2010-10-12 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Process for manufacturing dihydropteridinones and intermediates thereof
|
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
|
US9370535B2
(en)
|
2011-05-17 |
2016-06-21 |
Boehringer Ingelheim International Gmbh |
Method for treatment of advanced solid tumors
|
|
US9493466B2
(en)
|
2011-10-19 |
2016-11-15 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with TOR kinase inhibitors
|
|
EP2776444A4
(en)
|
2011-11-10 |
2015-07-22 |
Osi Pharmaceuticals Llc |
dihydropteridinones
|
|
ES2694413T3
(es)
|
2011-12-02 |
2018-12-20 |
Signal Pharmaceuticals, Llc |
Composiciones farmacéuticas de 7-(6-(2-hidroxipropan-2-il)piridin-3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino [2,3-b]pirazin-2(1H)-ona, una forma sólida de la misma y métodos para su uso
|
|
CA2864905A1
(en)
|
2012-02-24 |
2013-08-29 |
Signal Pharmaceuticals, Llc |
Methods for treating non- small cell lung cancer using tor kinase inhibitor combination therapy
|
|
AU2013203714B2
(en)
|
2012-10-18 |
2015-12-03 |
Signal Pharmaceuticals, Llc |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
|
|
HK1212207A1
(en)
|
2013-01-16 |
2016-06-10 |
西格诺药品有限公司 |
Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
|
|
HK1221150A1
(zh)
|
2013-04-17 |
2017-05-26 |
西格诺药品有限公司 |
用二氢吡嗪并-吡嗪类对癌症的治疗
|
|
WO2014172432A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
|
|
EA030808B1
(ru)
|
2013-04-17 |
2018-09-28 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
ПРИМЕНЕНИЕ 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1Н-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1Н)-ОНА В ЛЕЧЕНИИ МУЛЬТИФОРМНОЙ ГЛИОБЛАСТОМЫ
|
|
SG11201508527VA
(en)
|
2013-04-17 |
2015-11-27 |
Signal Pharm Llc |
Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
|
|
CA2909579A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
|
|
HK1221174A1
(zh)
|
2013-04-17 |
2017-05-26 |
西格诺药品有限公司 |
用於治疗癌症的包括tor激酶抑制剂和5-取代喹唑啉酮化合物的组合疗法
|
|
MX364101B
(es)
|
2013-04-17 |
2019-04-12 |
Signal Pharm Llc |
Terapia de combinación que comprende un compuesto de dihidropirazino-pirazina y un antagonista de receptor de andrógenos para tratar cáncer de próstata.
|
|
CA3143529A1
(en)
|
2013-05-29 |
2014-12-04 |
Signal Pharmaceuticals, Llc |
Pharmaceutical compositions 0f 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
|
|
US20150031699A1
(en)
|
2013-07-26 |
2015-01-29 |
Boehringer Ingelheim International Gmbh |
Treatment of myelodysplastic syndrome
|
|
US9718824B2
(en)
|
2014-04-16 |
2017-08-01 |
Signal Pharmaceuticals, Llc |
Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof
|
|
WO2015160880A1
(en)
|
2014-04-16 |
2015-10-22 |
Signal Pharmaceuticals, Llc |
SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
|
|
NZ714742A
(en)
|
2014-04-16 |
2017-04-28 |
Signal Pharm Llc |
Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
|
|
US9737535B2
(en)
|
2014-04-16 |
2017-08-22 |
Signal Pharmaceuticals, Llc |
Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines
|
|
PT3166607T
(pt)
|
2014-07-11 |
2022-12-07 |
Gilead Sciences Inc |
Moduladores de receptores de tipo toll para o tratamento do vih
|
|
NZ629796A
(en)
|
2014-07-14 |
2015-12-24 |
Signal Pharm Llc |
Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
|
|
KR20170024120A
(ko)
|
2014-07-14 |
2017-03-06 |
시그날 파마소티칼 엘엘씨 |
치환된 피롤로피리미딘 화합물을 사용한 암의 치료방법, 이의 조성물
|
|
AU2015318061B2
(en)
|
2014-09-16 |
2018-05-17 |
Gilead Sciences, Inc. |
Solid forms of a toll-like receptor modulator
|
|
CN107074860B
(zh)
|
2014-09-16 |
2022-07-15 |
吉利德科学公司 |
制备toll样受体调节剂的方法
|
|
US9867831B2
(en)
|
2014-10-01 |
2018-01-16 |
Boehringer Ingelheim International Gmbh |
Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
|
|
MY198676A
(en)
|
2017-06-22 |
2023-09-15 |
Celgene Corp |
Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
|
|
KR102272284B1
(ko)
*
|
2020-01-13 |
2021-07-02 |
금오공과대학교 산학협력단 |
정밀 압력제어가 가능한 다단 스프링 압력제어밸브
|
|
TW202523311A
(zh)
*
|
2023-10-16 |
2025-06-16 |
美商克洛諾斯生技有限公司 |
離胺酸乙醯基轉移酶抑制劑
|