PH27278A - Spiro-isoquinoline-pyrrolidine tetrones useful as aldose reductase inhibitors - Google Patents

Spiro-isoquinoline-pyrrolidine tetrones useful as aldose reductase inhibitors

Info

Publication number
PH27278A
PH27278A PH39372A PH39372A PH27278A PH 27278 A PH27278 A PH 27278A PH 39372 A PH39372 A PH 39372A PH 39372 A PH39372 A PH 39372A PH 27278 A PH27278 A PH 27278A
Authority
PH
Philippines
Prior art keywords
isoquinoline
spiro
useful
reductase inhibitors
aldose reductase
Prior art date
Application number
PH39372A
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of PH27278A publication Critical patent/PH27278A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PH39372A 1988-10-20 1989-10-17 Spiro-isoquinoline-pyrrolidine tetrones useful as aldose reductase inhibitors PH27278A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26043488A 1988-10-20 1988-10-20
US07/357,563 US4927831A (en) 1988-10-20 1989-05-26 Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

Publications (1)

Publication Number Publication Date
PH27278A true PH27278A (en) 1993-05-04

Family

ID=26947989

Family Applications (1)

Application Number Title Priority Date Filing Date
PH39372A PH27278A (en) 1988-10-20 1989-10-17 Spiro-isoquinoline-pyrrolidine tetrones useful as aldose reductase inhibitors

Country Status (9)

Country Link
US (1) US4927831A (da)
JP (1) JP2888559B2 (da)
KR (1) KR0143998B1 (da)
CA (1) CA1337351C (da)
DK (1) DK170702B1 (da)
HU (1) HU206211B (da)
IL (1) IL92054A (da)
PH (1) PH27278A (da)
PT (1) PT92025B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428066A (en) * 1989-03-08 1995-06-27 Larner; Joseph Method of reducing elevated blood sugar in humans
US5045544A (en) * 1990-05-21 1991-09-03 American Home Products Corporation N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5093496A (en) * 1990-05-21 1992-03-03 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5081241A (en) * 1990-10-11 1992-01-14 American Home Products Corporation Spiro-pyridazines and analogs thereof useful as aldose reductase inhibitors
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
US5130425A (en) * 1990-10-12 1992-07-14 American Home Products Corporation Spiro-lactams and analogs thereof useful as aldose reductase inhibitors
US5169948A (en) * 1991-05-22 1992-12-08 American Home Products Corporation Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors
US5106978A (en) * 1991-05-22 1992-04-21 American Home Products Corporation Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5221686A (en) * 1992-08-04 1993-06-22 American Home Products Corporation Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
EP1582204B1 (en) * 1999-03-03 2013-09-25 Eli Lilly & Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
CA2362016A1 (en) 1999-03-03 2000-09-08 Kenneth Philip Moder Echinocandin/carbohydrate complexes
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
US6777048B2 (en) 2002-12-18 2004-08-17 Eastman Chemical Company Polyester compositions containing silicon carbide
WO2005025558A1 (en) * 2003-09-12 2005-03-24 Applied Reserach Systems Ars Holding N.V. Sulfonamide derivatives for the treatment of diabetes
CA2534314C (en) * 2003-09-12 2012-11-13 Applied Research Systems Ars Holding N.V. Benzothiazole derivatives for the treatment of diabetes
WO2005097773A1 (en) * 2004-04-07 2005-10-20 Applied Research Systems Ars Holding N.V. 1,1’-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b inhibitors
EP1778275A2 (en) * 2004-08-12 2007-05-02 Wyeth Combination therapy for diabetes, obesity, and cardiovascular diseases using gdf-8 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5241586U (da) * 1975-09-18 1977-03-24
JPS5241587U (da) * 1975-09-18 1977-03-24
FR2525603A1 (fr) * 1982-04-27 1983-10-28 Adir Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique
FR2544317B2 (fr) * 1983-04-12 1985-07-05 Adir Benzoazacycloalkyl-spiro-imidazolidines et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
HU895335D0 (en) 1990-01-28
PT92025A (pt) 1990-04-30
PT92025B (pt) 1995-07-18
HU206211B (en) 1992-09-28
CA1337351C (en) 1995-10-17
IL92054A (en) 1994-07-31
JPH02164880A (ja) 1990-06-25
DK519189D0 (da) 1989-10-19
KR0143998B1 (ko) 1998-07-15
HUT52775A (en) 1990-08-28
DK519189A (da) 1990-04-21
KR900006334A (ko) 1990-05-07
IL92054A0 (en) 1990-07-12
JP2888559B2 (ja) 1999-05-10
US4927831A (en) 1990-05-22
DK170702B1 (da) 1995-12-11

Similar Documents

Publication Publication Date Title
PH27278A (en) Spiro-isoquinoline-pyrrolidine tetrones useful as aldose reductase inhibitors
JPS6426535A (en) Novel hmg-coa reductase inhibitor
AU8582591A (en) Multifunctional scale inhibitors
GR862006B (en) Novel hmg-coa reductase inhibitors
AU3580189A (en) Novel glucosidase inhibitors
EP0251625A3 (en) Novel hmg-coa reductase inhibitors
AU3464889A (en) Novel polyanhydrides
EP0403487A4 (en) Novel hmg-coa reductase inhibitors
AU613302B2 (en) Quinolyloxazole-2-ones useful as proteinkinase c inhibitors
GB2224734B (en) Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
EP0323866A3 (en) Novel hmg-coa reductase inhibitors
ZA886468B (en) Novel hmg-coa reductase inhibitors
JPS6463595A (en) Ribonucleotide reductase inhibitor
AU6593090A (en) Novel pyridyloxyazole-2-ones useful as proteinkinase c inhibitors
GB2188047B (en) Aldose reductase inhibitor
AU3298389A (en) Hammer for pile-drivers
EP0306263A3 (en) Novel hmg-coa reductase inhibitors
ZA897929B (en) Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
IE861411L (en) Spiro-imidazolidines as aldose reductase inhibitors
ZA851426B (en) 17 beta-n-monosubstituted carbamoyl-4-aza-5 alpha-androst-1-en-3-ones as 5 alpha reductase inhibitors
GB9303051D0 (en) 17b-nmonosubstituted carbamoyl-11-oxo-4-aza-5-a-androst-en-3-one testosterone-5-alpha reductase inhibitors
ZA874487B (en) Novel hmg-coa reductase inhibitors
EP0468974A4 (en) Novel hmg-coa reductase inhibitors
IE870041L (en) Heterocyclic aldose reductase inhibitors
IE882652L (en) NOVEL HMG-CoA REDUCTASE INHIBITORS