PH27177A - Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein - Google Patents
Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein Download PDFInfo
- Publication number
- PH27177A PH27177A PH32543A PH32543A PH27177A PH 27177 A PH27177 A PH 27177A PH 32543 A PH32543 A PH 32543A PH 32543 A PH32543 A PH 32543A PH 27177 A PH27177 A PH 27177A
- Authority
- PH
- Philippines
- Prior art keywords
- peptide
- protein
- amino acid
- falciparum
- asn
- Prior art date
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- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 108010078144 glutaminyl-glycine Proteins 0.000 description 1
- YQOKLYTXVFAUCW-UHFFFAOYSA-N guanidine;isothiocyanic acid Chemical compound N=C=S.NC(N)=N YQOKLYTXVFAUCW-UHFFFAOYSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000014726 immortalization of host cell Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 229940124735 malaria vaccine Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 229940101270 nicotinamide adenine dinucleotide (nad) Drugs 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- HJRIWDYVYNNCFY-UHFFFAOYSA-M potassium;dimethylarsinate Chemical compound [K+].C[As](C)([O-])=O HJRIWDYVYNNCFY-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012146 running buffer Substances 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLNZEKHULJKQBA-UHFFFAOYSA-N terbufos Chemical compound CCOP(=S)(OCC)SCSC(C)(C)C XLNZEKHULJKQBA-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- 210000003812 trophozoite Anatomy 0.000 description 1
- FEBNTWHYQKGEIQ-UHFFFAOYSA-N valerenic acid Chemical compound CC1CCC(C=C(C)C(O)=O)C2=C(C)CCC12 FEBNTWHYQKGEIQ-UHFFFAOYSA-N 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63314784A | 1984-07-23 | 1984-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH27177A true PH27177A (en) | 1993-04-02 |
Family
ID=24538462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH32543A PH27177A (en) | 1984-07-23 | 1985-07-17 | Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0187858B1 (de) |
| AT (1) | ATE78041T1 (de) |
| AU (1) | AU606031B2 (de) |
| DE (2) | DE187858T1 (de) |
| DK (1) | DK134186D0 (de) |
| HK (1) | HK85693A (de) |
| IL (1) | IL75788A (de) |
| NZ (2) | NZ230817A (de) |
| PH (1) | PH27177A (de) |
| WO (1) | WO1986000911A1 (de) |
| ZA (1) | ZA855232B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985003724A1 (en) * | 1984-02-21 | 1985-08-29 | National Research Development Corporation | Improvements in or relating to the production of malaria vaccines |
| US4707357A (en) * | 1984-06-26 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor |
| FR2566780B1 (fr) * | 1984-07-02 | 1987-02-06 | Pasteur Institut | Molecules comportant au moins une sequence peptidique porteuse d'un epitope caracteristique d'une proteine produite par des cellules infectees par les parasites du paludisme et compositions les contenant |
| NZ215023A (en) * | 1985-02-07 | 1989-07-27 | Smithkline Beckman Corp | Vaccine against plasmodium falciparum and antigenic peptides |
| ES8800273A1 (es) * | 1985-03-28 | 1987-11-01 | Univ New York | Perfeccionamientos en la fabricacion de conjugados de proteinas portadores de antigenos inmunogenicos para vacunas contra la malaria |
| EP0229829B1 (de) * | 1985-07-12 | 1995-02-22 | New York University | Mit dem plasmodium-vivax-circumsporozoit-protein übereinstimmendes immunogenes peptidantigen |
| EP0252588A3 (de) * | 1986-05-12 | 1989-07-12 | Smithkline Beecham Corporation | Verfahren zur Isolierung und Reinigung von P. falciparum CS-Protein in rekombinantem E. coli sowie seine Verwendung als Impfstoff |
| IT1198233B (it) * | 1986-12-23 | 1988-12-21 | Eniricerche Spa | Metodo per la determinazione di anticorpi antisporozoita di p. falciparum nel sangue umano |
| US5089406A (en) * | 1987-01-07 | 1992-02-18 | Allied-Signal Inc. | Method of producing a gene cassette coding for polypeptides with repeating amino acid sequences |
| EP0289110A3 (de) * | 1987-02-02 | 1990-01-24 | Swiss Serum and Vaccine Institute Berne | Konjugierter Malaria-Impfstoff |
| AT388934B (de) * | 1987-11-13 | 1989-09-25 | Wellcome Found | Rekombinationskonjugatprotein und neue vakzinen |
| US6130082A (en) * | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| IT1226728B (it) * | 1988-08-05 | 1991-02-05 | Eniricerche Spa | Coniugato peptidico immunologicamente attivo utile come vaccino antimalaria e metodo di immunizzazione impiegante lo stesso |
| IT1237764B (it) * | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4466917A (en) * | 1981-02-12 | 1984-08-21 | New York University | Malaria vaccine |
| US4707357A (en) * | 1984-06-26 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor |
| ATE70308T1 (de) * | 1984-09-12 | 1991-12-15 | Chiron Corp | Hybridpartikel-immunogene. |
| NZ215023A (en) * | 1985-02-07 | 1989-07-27 | Smithkline Beckman Corp | Vaccine against plasmodium falciparum and antigenic peptides |
| ES8800273A1 (es) * | 1985-03-28 | 1987-11-01 | Univ New York | Perfeccionamientos en la fabricacion de conjugados de proteinas portadores de antigenos inmunogenicos para vacunas contra la malaria |
-
1985
- 1985-07-11 ZA ZA855232A patent/ZA855232B/xx unknown
- 1985-07-12 IL IL75788A patent/IL75788A/xx not_active IP Right Cessation
- 1985-07-17 PH PH32543A patent/PH27177A/en unknown
- 1985-07-22 NZ NZ230817A patent/NZ230817A/xx unknown
- 1985-07-22 NZ NZ212816A patent/NZ212816A/en unknown
- 1985-07-23 EP EP85903931A patent/EP0187858B1/de not_active Expired - Lifetime
- 1985-07-23 AT AT85903931T patent/ATE78041T1/de not_active IP Right Cessation
- 1985-07-23 DE DE198585903931T patent/DE187858T1/de active Pending
- 1985-07-23 DE DE8585903931T patent/DE3586316T2/de not_active Expired - Lifetime
- 1985-07-23 WO PCT/US1985/001416 patent/WO1986000911A1/en active IP Right Grant
- 1985-07-23 AU AU46399/85A patent/AU606031B2/en not_active Ceased
-
1986
- 1986-03-24 DK DK134186A patent/DK134186D0/da not_active Application Discontinuation
-
1993
- 1993-08-19 HK HK856/93A patent/HK85693A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL75788A0 (en) | 1985-11-29 |
| HK85693A (en) | 1993-08-27 |
| NZ212816A (en) | 1990-01-29 |
| AU606031B2 (en) | 1991-01-31 |
| WO1986000911A1 (en) | 1986-02-13 |
| DE3586316D1 (de) | 1992-08-13 |
| NZ230817A (en) | 1990-10-26 |
| AU4639985A (en) | 1986-02-25 |
| DK134186A (da) | 1986-03-24 |
| EP0187858B1 (de) | 1992-07-08 |
| IL75788A (en) | 1992-06-21 |
| EP0187858A1 (de) | 1986-07-23 |
| DK134186D0 (da) | 1986-03-24 |
| DE187858T1 (de) | 1987-02-26 |
| ZA855232B (en) | 1986-02-26 |
| ATE78041T1 (de) | 1992-07-15 |
| DE3586316T2 (de) | 1992-12-10 |
| EP0187858A4 (de) | 1988-11-07 |
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