PH26986A - Ring-substituted 2-amino-1,2,3,4-tetrahydroanphthalenes pharmaceutical compositions containing same and method of use thereof - Google Patents

Ring-substituted 2-amino-1,2,3,4-tetrahydroanphthalenes pharmaceutical compositions containing same and method of use thereof Download PDF

Info

Publication number
PH26986A
PH26986A PH38650A PH38650A PH26986A PH 26986 A PH26986 A PH 26986A PH 38650 A PH38650 A PH 38650A PH 38650 A PH38650 A PH 38650A PH 26986 A PH26986 A PH 26986A
Authority
PH
Philippines
Prior art keywords
compound
mixture
halo
ether
hvdrogen
Prior art date
Application number
PH38650A
Other languages
English (en)
Inventor
James Arthur Nixon
Richard Paul Pioch
John Mehnert Schaus
Robert Daniel Titus
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PH26986A publication Critical patent/PH26986A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
PH38650A 1988-05-23 1989-05-16 Ring-substituted 2-amino-1,2,3,4-tetrahydroanphthalenes pharmaceutical compositions containing same and method of use thereof PH26986A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19723688A 1988-05-23 1988-05-23

Publications (1)

Publication Number Publication Date
PH26986A true PH26986A (en) 1992-12-28

Family

ID=22728578

Family Applications (1)

Application Number Title Priority Date Filing Date
PH38650A PH26986A (en) 1988-05-23 1989-05-16 Ring-substituted 2-amino-1,2,3,4-tetrahydroanphthalenes pharmaceutical compositions containing same and method of use thereof

Country Status (18)

Country Link
EP (1) EP0343830B1 (da)
JP (1) JP2795677B2 (da)
KR (1) KR900018048A (da)
CN (1) CN1024665C (da)
AT (1) ATE108446T1 (da)
AU (1) AU615747B2 (da)
CA (1) CA1335591C (da)
DE (1) DE68916705T2 (da)
DK (1) DK243989A (da)
ES (1) ES2058518T3 (da)
HU (1) HU208818B (da)
IL (1) IL90292A0 (da)
MX (1) MX16046A (da)
NZ (1) NZ229141A (da)
PH (1) PH26986A (da)
PT (1) PT90569B (da)
RU (2) RU2014330C1 (da)
ZA (1) ZA893619B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8904127D0 (sv) * 1989-12-07 1989-12-07 Astra Ab New biocyclic amino-substituted compounds
US5616610A (en) * 1989-12-22 1997-04-01 Astra Aktiebolag (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
EP0471515B1 (en) * 1990-08-15 1997-03-05 Eli Lilly And Company Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes and 3-aminothiochromanes
EP0498590B1 (en) * 1991-02-08 1997-04-09 Eli Lilly And Company Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
FR2681320B1 (fr) * 1991-09-12 1994-01-14 Synthelabo Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
US6303627B1 (en) * 1998-06-19 2001-10-16 Eli Lilly And Company Inhibitors of serotonin reuptake
JP2002533447A (ja) * 1998-12-24 2002-10-08 アストラゼネカ・アクチエボラーグ 神経疾患の治療に有用な１，４−ジアザシクロヘプタン誘導体
GB9914026D0 (en) * 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
DE10145779B4 (de) 2001-09-17 2012-11-15 Merck Patent Gmbh Fluorierte Cyclopenta[b]naphthaline und ihre Verwendung in Flüssigkristallmischungen
SI1831159T1 (sl) * 2004-12-21 2010-04-30 Hoffmann La Roche Derivati tetralina in indana ter njune uporabe
EP1851207B1 (en) * 2005-02-10 2009-07-01 Neurosearch A/S Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
FR2883876B1 (fr) * 2005-03-30 2007-05-04 Servier Lab Derives d'indanyl-piperazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP4019485B1 (en) 2019-08-23 2024-08-07 Mochida Pharmaceutical Co., Ltd. Method for producing heterocyclidene acetamide derivatives
EP4410989A2 (en) 2019-08-23 2024-08-07 Mochida Pharmaceutical Co., Ltd. Method for producing heterocyclidene acetamide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK309678A (da) * 1977-07-18 1979-01-19 Sandoz Ag Fremgangsmaade til fremstilling af tetralinderivater
GR71991B (da) * 1980-01-21 1983-08-26 Delalande Sa
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline

Also Published As

Publication number Publication date
DK243989A (da) 1989-11-24
AU615747B2 (en) 1991-10-10
CN1038644A (zh) 1990-01-10
PT90569B (pt) 1994-08-31
JPH0217179A (ja) 1990-01-22
NZ229141A (en) 1991-08-27
KR900018048A (ko) 1990-12-20
DE68916705D1 (de) 1994-08-18
CN1024665C (zh) 1994-05-25
ATE108446T1 (de) 1994-07-15
MX16046A (es) 1993-10-01
DK243989D0 (da) 1989-05-19
EP0343830A2 (en) 1989-11-29
ES2058518T3 (es) 1994-11-01
EP0343830A3 (en) 1990-11-28
DE68916705T2 (de) 1994-11-24
AU3482089A (en) 1989-11-23
EP0343830B1 (en) 1994-07-13
HU208818B (en) 1994-01-28
HUT50799A (en) 1990-03-28
JP2795677B2 (ja) 1998-09-10
IL90292A0 (en) 1989-12-15
PT90569A (pt) 1989-11-30
RU2014330C1 (ru) 1994-06-15
ZA893619B (en) 1991-01-30
RU2001911C1 (ru) 1993-10-30
CA1335591C (en) 1995-05-16

Similar Documents

Publication Publication Date Title
PH26986A (en) Ring-substituted 2-amino-1,2,3,4-tetrahydroanphthalenes pharmaceutical compositions containing same and method of use thereof
US5047431A (en) 1,1,2-triphenylbut-1-ene derivatives
US4085225A (en) Oxime ethers having anti-depressive activity
DE2635276A1 (de) Tetrahydroisochinolin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
IE58073B1 (en) Glutarimide antianxiety and antihypertensive agents
WO1988007526A1 (en) Substituted benzazepines, their preparation and pharmaceutical compositions containing them
DK141624B (da) Analogifremgangsmåde til fremstilling af morphinanderivater.
FI83512B (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla fusionerade bensazepinfoereningar.
US4735944A (en) Spiro-dioxolanes, -dithiolanes and -oxothiolanes, and their use in mental therapy
IE52649B1 (en) Octahydrobenzo(f)quinoline compounds
DE3002367A1 (de) 2-substituierte trans-5-aryl-2,3,4,4a,5, 9b-hexahydro-1h-pyrido eckige klammer auf 4,3-b eckige klammer zu indole
DE69112201T2 (de) 4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung.
US5025009A (en) Novel benzazepine derivatives
US5026707A (en) Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
DE3315467A1 (de) Azepinoindole, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3780649T2 (de) Kondensierte benzazepine.
US4073912A (en) Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
US3691159A (en) Tricyclic heterocyclic amides of diallylamino-alkanoic acids and salts thereof
US4977176A (en) Pilocarpine compounds which are used as pharmaceutical agents
CA2260698A1 (en) Pyrrolidine and piperidine derivatives
US3830818A (en) Amino quinobenzazepines
AU8325987A (en) Antipsychotic amino-polyhydro-benz-(iso)quinolines and intermediates
NL8701938A (nl) Derivaten van 2,3,4,5,6,7-hexahydro 2,7-methano 1,5-benzoxazonine (resp. 1,4-benzoxazonine), werkwijze ter bereiding ervan en medicijnen, die deze verbinding bevatten.
Brown et al. Synthesis of A New Class of Antishock Agents1a
GB1596170A (en) 1,2,3,4,4a,10b-hexahydro-benz(f)isouqinolines