PH26910A - Fenamate 1,3,4-thiadiazoles and 1,3,4,-oxadiazoles as anti-inflammatory agents - Google Patents
Fenamate 1,3,4-thiadiazoles and 1,3,4,-oxadiazoles as anti-inflammatory agents Download PDFInfo
- Publication number
- PH26910A PH26910A PH40627A PH40627A PH26910A PH 26910 A PH26910 A PH 26910A PH 40627 A PH40627 A PH 40627A PH 40627 A PH40627 A PH 40627A PH 26910 A PH26910 A PH 26910A
- Authority
- PH
- Philippines
- Prior art keywords
- compound
- phenyl
- oxadiazol
- dichloro
- amino
- Prior art date
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- -1 Fenamate 1,3,4-thiadiazoles Chemical class 0.000 title claims description 46
- 229940121363 anti-inflammatory agent Drugs 0.000 title description 3
- 239000002260 anti-inflammatory agent Substances 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 108
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 43
- 150000003839 salts Chemical class 0.000 claims description 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 25
- 229910052702 rhenium Inorganic materials 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 150000002367 halogens Chemical class 0.000 claims description 10
- 229960000789 guanidine hydrochloride Drugs 0.000 claims description 9
- 229910052717 sulfur Chemical group 0.000 claims description 9
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 7
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000004381 Choline salt Substances 0.000 claims description 6
- 235000019417 choline salt Nutrition 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 159000000000 sodium salts Chemical class 0.000 claims description 6
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 150000003248 quinolines Chemical class 0.000 claims description 5
- 206010061218 Inflammation Diseases 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
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- 230000004054 inflammatory process Effects 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- NHRBGODRNWECEP-UHFFFAOYSA-N [5-[2-(2,6-dichloro-3-methylanilino)phenyl]-1,3,4-oxadiazol-2-yl]cyanamide Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C=2OC(NC#N)=NN=2)=C1Cl NHRBGODRNWECEP-UHFFFAOYSA-N 0.000 claims description 3
- 125000002252 acyl group Chemical group 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000011593 sulfur Chemical group 0.000 claims description 3
- MIPNEZPUXKXLGS-UHFFFAOYSA-N 5-[2-(2,3-dimethylanilino)phenyl]-3h-1,3,4-oxadiazol-2-one Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C=2OC(=O)NN=2)=C1C MIPNEZPUXKXLGS-UHFFFAOYSA-N 0.000 claims description 2
- KIECGCXXVDIPRK-UHFFFAOYSA-N 5-[2-(2,6-dichloro-3-methylanilino)phenyl]-3h-1,3,4-oxadiazole-2-thione Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C=2OC(=S)NN=2)=C1Cl KIECGCXXVDIPRK-UHFFFAOYSA-N 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36440789A | 1989-06-09 | 1989-06-09 | |
| US50676890A | 1990-04-12 | 1990-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26910A true PH26910A (en) | 1992-12-03 |
Family
ID=27002463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH40627A PH26910A (en) | 1989-06-09 | 1990-06-06 | Fenamate 1,3,4-thiadiazoles and 1,3,4,-oxadiazoles as anti-inflammatory agents |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5462952A (de) |
| EP (1) | EP0401857A3 (de) |
| JP (1) | JP3086692B2 (de) |
| KR (1) | KR910000684A (de) |
| AU (1) | AU627034B2 (de) |
| CA (1) | CA2018517A1 (de) |
| FI (1) | FI902771A0 (de) |
| NO (1) | NO902548L (de) |
| NZ (1) | NZ233981A (de) |
| PH (1) | PH26910A (de) |
| PT (1) | PT94328A (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212189A (en) * | 1991-12-17 | 1993-05-18 | Warner-Lambert Company | Thiadiazole or oxadiazole analogs of fenamic acids containing substituted hydroxamate side chains as antiinflammatory agents |
| US5578639A (en) * | 1994-07-01 | 1996-11-26 | Warner-Lambert Company | PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption |
| US6310060B1 (en) | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
| ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| EP2671508B1 (de) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-Informatiksystem |
| CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
| JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CA3062294A1 (en) | 2017-05-03 | 2018-11-08 | Vivace Therapeutics, Inc. | Non-fused tricyclic compounds |
| CN111542315B (zh) | 2017-08-21 | 2023-05-12 | 维瓦斯治疗公司 | 苯并磺酰基化合物 |
| US11524943B1 (en) | 2017-12-06 | 2022-12-13 | Vivace Therapeutics, Inc. | Benzocarbonyl compounds |
| EP3793551A4 (de) | 2018-05-16 | 2022-01-26 | Vivace Therapeutics, Inc. | Oxadiazolverbindungen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH479599A (de) * | 1965-04-12 | 1969-10-15 | Bristol Myers Co | Verfahren zur Herstellung von Verbindungen von Nitrilen mit Stickstoffwasserstoffsäure oder Aziden |
| GB1166861A (en) * | 1966-01-15 | 1969-10-15 | Aspro Nicholas Ltd | New Diphenylamine Derivatives and Compositions containing them |
| DE1930263B2 (de) * | 1969-06-13 | 1976-11-11 | Agfa-Gevaert Ag, 5090 Leverkusen | Verfahren zur herstellung photographischer silberbilder |
| EP0084673B1 (de) * | 1982-01-22 | 1986-04-02 | BASF Aktiengesellschaft | Aminothiadiazole, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung unerwünschten Pflanzenwuchses |
| IL90192A0 (en) * | 1988-05-13 | 1989-12-15 | Schering Ag | Azole ether derivatives and pesticidal compositions containing the same |
-
1990
- 1990-06-04 FI FI902771A patent/FI902771A0/fi not_active Application Discontinuation
- 1990-06-06 PH PH40627A patent/PH26910A/en unknown
- 1990-06-07 CA CA002018517A patent/CA2018517A1/en not_active Abandoned
- 1990-06-07 AU AU56904/90A patent/AU627034B2/en not_active Ceased
- 1990-06-07 NZ NZ233981A patent/NZ233981A/en unknown
- 1990-06-08 KR KR1019900008408A patent/KR910000684A/ko not_active Application Discontinuation
- 1990-06-08 EP EP19900110900 patent/EP0401857A3/de not_active Withdrawn
- 1990-06-08 PT PT94328A patent/PT94328A/pt not_active Application Discontinuation
- 1990-06-08 JP JP02148887A patent/JP3086692B2/ja not_active Expired - Fee Related
- 1990-06-08 NO NO90902548A patent/NO902548L/no unknown
-
1993
- 1993-09-08 US US08/118,480 patent/US5462952A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3086692B2 (ja) | 2000-09-11 |
| AU627034B2 (en) | 1992-08-13 |
| US5462952A (en) | 1995-10-31 |
| EP0401857A2 (de) | 1990-12-12 |
| NO902548D0 (no) | 1990-06-08 |
| AU5690490A (en) | 1990-12-13 |
| PT94328A (pt) | 1991-02-08 |
| JPH0374375A (ja) | 1991-03-28 |
| KR910000684A (ko) | 1991-01-30 |
| NO902548L (no) | 1990-12-10 |
| NZ233981A (en) | 1992-10-28 |
| FI902771A0 (fi) | 1990-06-04 |
| EP0401857A3 (de) | 1991-07-31 |
| CA2018517A1 (en) | 1990-12-09 |
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