PH26151A - A-aryl-substituted-2,3-dihydro-imidazo(1,2-a)furo and thieno pyridines pharmaceutical compositions containing the same and method of use thereof - Google Patents
A-aryl-substituted-2,3-dihydro-imidazo(1,2-a)furo and thieno pyridines pharmaceutical compositions containing the same and method of use thereof Download PDFInfo
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- PH26151A PH26151A PH38610A PH38610A PH26151A PH 26151 A PH26151 A PH 26151A PH 38610 A PH38610 A PH 38610A PH 38610 A PH38610 A PH 38610A PH 26151 A PH26151 A PH 26151A
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- 231100000225 lethality Toxicity 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 150000002642 lithium compounds Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- AYLOVBNEYSUPQC-UHFFFAOYSA-N methyl 4-trimethylsilylbenzoate Chemical compound COC(=O)C1=CC=C([Si](C)(C)C)C=C1 AYLOVBNEYSUPQC-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229940100692 oral suspension Drugs 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012746 preparative thin layer chromatography Methods 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000008259 solid foam Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19056688A | 1988-05-05 | 1988-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26151A true PH26151A (en) | 1992-03-18 |
Family
ID=22701867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH38610A PH26151A (en) | 1988-05-05 | 1989-05-04 | A-aryl-substituted-2,3-dihydro-imidazo(1,2-a)furo and thieno pyridines pharmaceutical compositions containing the same and method of use thereof |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0341213B1 (fr) |
| JP (1) | JPH01319484A (fr) |
| AT (1) | ATE118777T1 (fr) |
| AU (1) | AU626295B2 (fr) |
| CA (1) | CA1334754C (fr) |
| DE (1) | DE68921239T2 (fr) |
| DK (1) | DK218989A (fr) |
| ES (1) | ES2069606T3 (fr) |
| IE (1) | IE891445L (fr) |
| IL (1) | IL90172A (fr) |
| NZ (1) | NZ228968A (fr) |
| PH (1) | PH26151A (fr) |
| ZA (1) | ZA893343B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2781482B1 (fr) * | 1998-07-27 | 2001-08-31 | Adir | Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0765198B2 (ja) * | 1986-06-27 | 1995-07-12 | 三洋電機株式会社 | ドライエツチングプロセスの評価方法 |
| EP0258175B1 (fr) * | 1986-07-14 | 1992-04-01 | Sandoz Ag | Imidazo[2,1-a]isoquinoléines, substituées en 5 par hétéro ou aryle |
-
1989
- 1989-05-01 AT AT89810333T patent/ATE118777T1/de active
- 1989-05-01 ES ES89810333T patent/ES2069606T3/es not_active Expired - Lifetime
- 1989-05-01 EP EP89810333A patent/EP0341213B1/fr not_active Expired - Lifetime
- 1989-05-01 DE DE68921239T patent/DE68921239T2/de not_active Expired - Fee Related
- 1989-05-02 JP JP1112323A patent/JPH01319484A/ja active Pending
- 1989-05-03 AU AU33977/89A patent/AU626295B2/en not_active Ceased
- 1989-05-03 NZ NZ228968A patent/NZ228968A/en unknown
- 1989-05-03 IE IE891445A patent/IE891445L/xx unknown
- 1989-05-03 DK DK218989A patent/DK218989A/da not_active Application Discontinuation
- 1989-05-03 IL IL90172A patent/IL90172A/xx unknown
- 1989-05-03 CA CA000598585A patent/CA1334754C/fr not_active Expired - Fee Related
- 1989-05-04 PH PH38610A patent/PH26151A/en unknown
- 1989-05-05 ZA ZA893343A patent/ZA893343B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3397789A (en) | 1989-11-09 |
| EP0341213B1 (fr) | 1995-02-22 |
| IE891445L (en) | 1989-11-05 |
| ES2069606T3 (es) | 1995-05-16 |
| CA1334754C (fr) | 1995-03-14 |
| DK218989A (da) | 1989-11-06 |
| ZA893343B (en) | 1991-01-30 |
| EP0341213A2 (fr) | 1989-11-08 |
| ATE118777T1 (de) | 1995-03-15 |
| JPH01319484A (ja) | 1989-12-25 |
| IL90172A0 (en) | 1989-12-15 |
| DE68921239D1 (de) | 1995-03-30 |
| NZ228968A (en) | 1992-01-29 |
| AU626295B2 (en) | 1992-07-30 |
| EP0341213A3 (fr) | 1991-05-29 |
| DK218989D0 (da) | 1989-05-03 |
| DE68921239T2 (de) | 1995-09-14 |
| IL90172A (en) | 1992-11-15 |
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