PH26079A - Long lasting contraceptive suppository composition and method of use - Google Patents
Long lasting contraceptive suppository composition and method of use Download PDFInfo
- Publication number
- PH26079A PH26079A PH39100A PH39100A PH26079A PH 26079 A PH26079 A PH 26079A PH 39100 A PH39100 A PH 39100A PH 39100 A PH39100 A PH 39100A PH 26079 A PH26079 A PH 26079A
- Authority
- PH
- Philippines
- Prior art keywords
- agent
- suppository
- gum
- composition
- spermicidal
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 92
- 239000000829 suppository Substances 0.000 title claims description 32
- 230000002254 contraceptive effect Effects 0.000 title claims description 27
- 239000003433 contraceptive agent Substances 0.000 title claims description 22
- 238000000034 method Methods 0.000 title claims description 22
- 230000005923 long-lasting effect Effects 0.000 title claims description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 39
- 239000000934 spermatocidal agent Substances 0.000 claims description 37
- 229940087419 nonoxynol-9 Drugs 0.000 claims description 31
- 229920004918 nonoxynol-9 Polymers 0.000 claims description 31
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 claims description 31
- 239000002270 dispersing agent Substances 0.000 claims description 21
- 229920001223 polyethylene glycol Polymers 0.000 claims description 20
- 239000002511 suppository base Substances 0.000 claims description 17
- 239000000230 xanthan gum Substances 0.000 claims description 15
- 229920001285 xanthan gum Polymers 0.000 claims description 15
- 229940082509 xanthan gum Drugs 0.000 claims description 15
- 235000010493 xanthan gum Nutrition 0.000 claims description 15
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 14
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 12
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 12
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims description 11
- 229910021485 fumed silica Inorganic materials 0.000 claims description 11
- 238000003780 insertion Methods 0.000 claims description 10
- 230000037431 insertion Effects 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 10
- 210000001215 vagina Anatomy 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000000377 silicon dioxide Substances 0.000 claims description 9
- HNLXNOZHXNSSPN-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCOCCOCCOCCO)C=C1 HNLXNOZHXNSSPN-UHFFFAOYSA-N 0.000 claims description 7
- NMXDTPBZWZGMMO-UHFFFAOYSA-N 4-(2-methyl-5-propan-2-ylcyclohexyl)phenol Chemical compound C1C(C(C)C)CCC(C)C1C1=CC=C(O)C=C1 NMXDTPBZWZGMMO-UHFFFAOYSA-N 0.000 claims description 7
- 229960001112 menfegol Drugs 0.000 claims description 7
- 229940098514 octoxynol-9 Drugs 0.000 claims description 7
- 229920002114 octoxynol-9 Polymers 0.000 claims description 7
- 210000003679 cervix uteri Anatomy 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 229910002027 silica gel Inorganic materials 0.000 claims description 6
- 239000000741 silica gel Substances 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 3
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 230000013011 mating Effects 0.000 description 23
- 238000009472 formulation Methods 0.000 description 14
- 239000000047 product Substances 0.000 description 8
- 230000001150 spermicidal effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 229920002534 Polyethylene Glycol 1450 Polymers 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000004899 motility Effects 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 238000013270 controlled release Methods 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 241000282566 Macaca arctoides Species 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 239000006216 vaginal suppository Substances 0.000 description 2
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 208000034423 Delivery Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229960001716 benzalkonium Drugs 0.000 description 1
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000009677 vaginal delivery Effects 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/14—Topical contraceptives and spermacides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/15—Suppositories
Landscapes
- Health & Medical Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/232,816 US4999342A (en) | 1988-08-16 | 1988-08-16 | Long lasting contraceptive suppository composition and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26079A true PH26079A (en) | 1992-02-06 |
Family
ID=22874723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH39100A PH26079A (en) | 1988-08-16 | 1989-08-15 | Long lasting contraceptive suppository composition and method of use |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4999342A (no) |
| EP (1) | EP0359402A3 (no) |
| JP (1) | JP2845325B2 (no) |
| AU (1) | AU623427B2 (no) |
| CA (1) | CA1338877C (no) |
| DK (1) | DK400189A (no) |
| FI (1) | FI98342C (no) |
| IL (1) | IL91290A0 (no) |
| MX (1) | MX164229B (no) |
| NO (1) | NO893275L (no) |
| NZ (1) | NZ230294A (no) |
| PH (1) | PH26079A (no) |
| PT (1) | PT91454B (no) |
| ZA (1) | ZA896228B (no) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4015543A1 (de) * | 1990-05-15 | 1991-11-21 | Bayer Ag | Spermicides beschichtungsmittel |
| DK116591D0 (da) * | 1991-06-17 | 1991-06-17 | Ferring Farma Lab | Fremgangsmaade til fremstilling af suppositorier ved komprimering og suppositorier opnaaet ved fremgangsmaaden |
| US5192802A (en) * | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| US5215976A (en) * | 1991-10-28 | 1993-06-01 | Mona Industries, Inc. | Phospholipids useful as spermicidal agents |
| NL9102142A (nl) * | 1991-12-20 | 1993-07-16 | Dagra Pharma Bv | Zetpillen met vertraagde afgifte en werkwijze voor de bereiding daarvan. |
| FR2728464B1 (fr) | 1994-12-22 | 1997-04-30 | Innothera Lab Sa | Forme galenique unitaire, son procede d'obtention et ses utilisations |
| US5741525A (en) * | 1995-10-24 | 1998-04-21 | Marshall University Research Corporation | Vaginal pharmaceutical hydrogen peroxide composition |
| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| US6245808B1 (en) | 1998-11-05 | 2001-06-12 | Parker Hughes Institute | Oxy-vanadium (IV) complexes having spermicidal activity |
| US6051603A (en) * | 1998-01-20 | 2000-04-18 | Wayne Hughes Institute | Vanadium (IV) metallocene complexes having sperm motility inhibiting activity |
| US6432941B1 (en) | 1998-01-20 | 2002-08-13 | Parker Hughes Institute | Vanadium compounds for treating cancer |
| US6139848A (en) * | 1999-02-12 | 2000-10-31 | Mcneil-Ppc, Inc. | Personal lubricant compositions |
| EP1263411B1 (en) * | 2000-03-07 | 2010-12-01 | Rush-Presbyterian-St.Luke's Medical Center | Compositions and use thereof for trapping and inactivating pathogenic microbes and spermatozoa |
| US20040047910A1 (en) * | 2000-07-07 | 2004-03-11 | Christian Beckett | Suppository and composition comprising at least one polyethylene glycol |
| PT1615646E (pt) * | 2003-04-08 | 2015-02-12 | Progenics Pharm Inc | Formulações farmacêuticas com metilnaltrexona |
| AU2004267383A1 (en) * | 2003-08-14 | 2005-03-03 | The Bio Balance Corporation | Bacterial strains, compositions including same and probiotic use thereof |
| US20050214364A1 (en) * | 2004-03-23 | 2005-09-29 | Hutman Herbert W | Products and methods for treating vaginal infections |
| US20070065504A1 (en) * | 2004-03-23 | 2007-03-22 | Lin Shun Y | Products and methods for treating vaginal infections |
| AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
| EP2134718A2 (en) | 2007-03-29 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof |
| DK2565195T3 (en) * | 2007-03-29 | 2015-06-29 | Wyeth Llc | PERIPHERAL OPIOID RECEPTOR AND ANTAGONISTS AND USES THEREOF |
| EP2137191B8 (en) | 2007-03-29 | 2016-06-08 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof |
| JP5358587B2 (ja) * | 2008-02-06 | 2013-12-04 | プロジェニックス・ファーマシューティカルス・インコーポレイテッド | （ｒ），（ｒ）−２，２’−ビス−メチルナルトレキソンの製造及び用途 |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| US9011909B2 (en) * | 2010-09-03 | 2015-04-21 | Wisconsin Pharmacal Company, Llc | Prebiotic suppositories |
| WO2013187984A1 (en) * | 2012-06-13 | 2013-12-19 | Evofem, Inc. | Compositions and methods for enhancing the efficacy of contraceptive microbicides |
| CN114452298A (zh) | 2013-12-19 | 2022-05-10 | 伊沃菲姆股份有限公司 | 使用基于藻酸的抗微生物化合物抑制炎症和疾病的组合物和方法 |
| CA2897038C (en) | 2014-07-14 | 2016-10-04 | Novicol International Holding Inc. | Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof |
| EP3522879A4 (en) | 2016-10-04 | 2020-06-03 | Evofem, Inc. | METHOD OF TREATING AND PREVENTING BACTERIAL VAGINOSIS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932613A (en) * | 1973-08-20 | 1976-01-13 | Morton-Norwich Products, Inc. | Method of preventing leakage from body orifices when utilizing suppositories as a source of medication |
| US4187286A (en) * | 1979-01-02 | 1980-02-05 | G&W Laboratories, Inc. | Contraceptive suppository |
| JPS58152809A (ja) * | 1982-03-05 | 1983-09-10 | Eisai Co Ltd | 安定な発泡性「膣」坐剤 |
| US4659696A (en) * | 1982-04-30 | 1987-04-21 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition and its nasal or vaginal use |
| CA1207231A (en) * | 1982-08-24 | 1986-07-08 | Hans W. Zulliger | Medicated suppository |
| US4551148A (en) * | 1982-09-07 | 1985-11-05 | Kv Pharmaceutical Company | Vaginal delivery systems and their methods of preparation and use |
| NZ222698A (en) * | 1987-01-08 | 1990-02-26 | Squibb & Sons Inc | Bioadhesive suppository formulations comprising a medicament, water, a hydrocolloid and low melting point base |
-
1988
- 1988-08-16 US US07/232,816 patent/US4999342A/en not_active Expired - Lifetime
-
1989
- 1989-08-11 IL IL91290A patent/IL91290A0/xx unknown
- 1989-08-14 NZ NZ230294A patent/NZ230294A/xx unknown
- 1989-08-14 CA CA000608293A patent/CA1338877C/en not_active Expired - Lifetime
- 1989-08-14 AU AU39599/89A patent/AU623427B2/en not_active Expired
- 1989-08-15 ZA ZA896228A patent/ZA896228B/xx unknown
- 1989-08-15 EP EP89308256A patent/EP0359402A3/en not_active Withdrawn
- 1989-08-15 NO NO89893275A patent/NO893275L/no unknown
- 1989-08-15 DK DK400189A patent/DK400189A/da not_active Application Discontinuation
- 1989-08-15 PH PH39100A patent/PH26079A/en unknown
- 1989-08-15 FI FI893840A patent/FI98342C/fi active IP Right Grant
- 1989-08-16 JP JP1210214A patent/JP2845325B2/ja not_active Expired - Lifetime
- 1989-08-16 MX MX17220A patent/MX164229B/es unknown
- 1989-08-16 PT PT91454A patent/PT91454B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI893840A (fi) | 1990-02-17 |
| NZ230294A (en) | 1991-10-25 |
| ZA896228B (en) | 1991-04-24 |
| DK400189A (da) | 1990-02-17 |
| AU3959989A (en) | 1990-02-22 |
| AU623427B2 (en) | 1992-05-14 |
| CA1338877C (en) | 1997-01-28 |
| PT91454A (pt) | 1990-03-08 |
| FI893840A0 (fi) | 1989-08-15 |
| FI98342C (fi) | 1997-06-10 |
| NO893275L (no) | 1990-02-19 |
| JPH02104517A (ja) | 1990-04-17 |
| US4999342A (en) | 1991-03-12 |
| EP0359402A3 (en) | 1990-04-11 |
| EP0359402A2 (en) | 1990-03-21 |
| IL91290A0 (en) | 1990-03-19 |
| DK400189D0 (da) | 1989-08-15 |
| PT91454B (pt) | 1996-06-28 |
| JP2845325B2 (ja) | 1999-01-13 |
| FI98342B (fi) | 1997-02-28 |
| MX164229B (es) | 1992-07-27 |
| NO893275D0 (no) | 1989-08-15 |
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