PH25507A - N-aryl-piperazinalkanamides usefule for improving sleep - Google Patents

N-aryl-piperazinalkanamides usefule for improving sleep

Info

Publication number
PH25507A
PH25507A PH36714A PH36714A PH25507A PH 25507 A PH25507 A PH 25507A PH 36714 A PH36714 A PH 36714A PH 36714 A PH36714 A PH 36714A PH 25507 A PH25507 A PH 25507A
Authority
PH
Philippines
Prior art keywords
6alkyl
aminocarbonyl
optionally substituted
piperazinalkanamides
usefule
Prior art date
Application number
PH36714A
Other languages
English (en)
Inventor
Georges Henri Paul Van Daele
Freddy Francois Vlaeminck
Marc Gustaaf Celine Verdonck
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PH25507A publication Critical patent/PH25507A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
PH36714A 1987-04-01 1988-03-30 N-aryl-piperazinalkanamides usefule for improving sleep PH25507A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3412987A 1987-04-01 1987-04-01

Publications (1)

Publication Number Publication Date
PH25507A true PH25507A (en) 1991-07-24

Family

ID=21874492

Family Applications (1)

Application Number Title Priority Date Filing Date
PH36714A PH25507A (en) 1987-04-01 1988-03-30 N-aryl-piperazinalkanamides usefule for improving sleep

Country Status (21)

Country Link
EP (2) EP0727421B1 (ko)
JP (1) JP2574377B2 (ko)
KR (1) KR960016539B1 (ko)
AT (2) ATE142627T1 (ko)
AU (1) AU609790B2 (ko)
CA (1) CA1315790C (ko)
DE (2) DE3855520T2 (ko)
DK (1) DK174878B1 (ko)
ES (2) ES2167510T3 (ko)
FI (1) FI97617C (ko)
GR (1) GR3020983T3 (ko)
HK (1) HK1006020A1 (ko)
HU (2) HUT57740A (ko)
IE (1) IE81057B1 (ko)
IL (1) IL85919A (ko)
NO (1) NO178660C (ko)
NZ (1) NZ223847A (ko)
PH (1) PH25507A (ko)
PT (1) PT87118B (ko)
RU (1) RU2014328C1 (ko)
ZA (1) ZA882352B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840896A (en) * 1989-11-22 1998-11-24 Janssen Pharmaceutica, N.V. Method of preventing or limiting reperfusion damage
DE69007471T2 (de) * 1989-11-22 1994-06-23 Janssen Pharmaceutica N.V., Beerse Verfahren zur verhütung oder zur begrenzung einer reperfusionsschädigung.
JP2660086B2 (ja) * 1990-07-03 1997-10-08 明治製菓株式会社 脳及び心機能障害改善剤
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
SE9202266D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel piperazine carboxamides
ES2125285T3 (es) * 1992-07-31 1999-03-01 Bristol Myers Squibb Co Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles.
EP0756593B1 (de) * 1994-04-20 2000-09-20 Lonza Ag Verfahren zur herstellung von 2-piperazincarbonsäurederivaten
US5866574A (en) * 1997-04-10 1999-02-02 Kyowa Hakko Kogyo Co., Ltd. Pancreatitis remedy
DE69814089T2 (de) 1997-06-16 2004-02-19 Janssen Pharmaceutica N.V. Verwendung von einem draflazin analog zur schmerzbehandlung
UA89503C2 (uk) * 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
EP1836179B1 (en) 2004-12-30 2015-05-06 Janssen Pharmaceutica NV Piperidine- and piperazine-1-carboxylic acid amide derivatives and related compounds as modulators of fatty acid amide hydrolase (faah) for the treatment of anxiety, pain and other conditions
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
CN110511220B (zh) * 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia

Also Published As

Publication number Publication date
AU1384788A (en) 1988-10-06
NO881407L (no) 1988-10-03
DK174878B1 (da) 2004-01-12
FI881525A (fi) 1988-10-02
DE3855520T2 (de) 1997-02-06
JPS63290869A (ja) 1988-11-28
FI97617C (fi) 1997-01-27
IL85919A0 (en) 1988-09-30
IE880989L (en) 1988-10-01
ATE207474T1 (de) 2001-11-15
GR3020983T3 (en) 1996-12-31
DK179788A (da) 1988-10-02
EP0727421A1 (en) 1996-08-21
DK179788D0 (da) 1988-03-30
ATE142627T1 (de) 1996-09-15
IE81057B1 (en) 1999-12-29
FI97617B (fi) 1996-10-15
ZA882352B (en) 1989-12-27
EP0285219A2 (en) 1988-10-05
FI881525A0 (fi) 1988-03-31
ES2091183T3 (es) 1996-11-01
RU2014328C1 (ru) 1994-06-15
EP0727421B1 (en) 2001-10-24
HUT57740A (en) 1991-12-30
EP0285219A3 (en) 1991-07-03
ES2167510T3 (es) 2002-05-16
DE3855520D1 (de) 1996-10-17
EP0285219B1 (en) 1996-09-11
KR880012566A (ko) 1988-11-28
NO178660B (no) 1996-01-29
JP2574377B2 (ja) 1997-01-22
AU609790B2 (en) 1991-05-09
DE3856501T2 (de) 2004-04-29
NO881407D0 (no) 1988-03-29
HK1006020A1 (en) 1999-02-05
HU211129A9 (en) 1995-10-30
IL85919A (en) 1992-12-01
KR960016539B1 (ko) 1996-12-14
CA1315790C (en) 1993-04-06
NZ223847A (en) 1989-12-21
PT87118A (pt) 1988-04-01
DE3856501D1 (de) 2001-11-29
PT87118B (pt) 1992-07-31
NO178660C (no) 1996-05-08

Similar Documents

Publication Publication Date Title
HUT70426A (en) Pyrazolo-pyrimidine derivatives, process for preparing them and pharmaceutical compositions containing them as active agents
SG15689G (en) Substituted acyl derivatives of 1,2,3,4-tetrahydroiso-quinoline-3-carboxylic acids,salts thereof,pharmaceutical compositions containing the derivatives or salts,and the production of the same
GR3004114T3 (ko)
PH25507A (en) N-aryl-piperazinalkanamides usefule for improving sleep
HUT43051A (en) Process for preparing pyridine-carboxylic acid derivatives and pharmaceutical compositions containing thereof as active ingredients
IL107961A0 (en) Phenoxy- and phenoxyalkyl-piperidines and pharmaceutical compositions containing them
HUT40101A (en) Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
IE890177L (en) Piperidinyl derivatives
KR0133073B1 (en) Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-ones
NZ233526A (en) Pyridazine derivatives and their pharmaceutical compositions
IL87107A0 (en) Naphthothiazepine derivatives,their preparation and pharmaceutical compositions containing them
MY101628A (en) Sulfonamide compounds and salts thereof, herbicidal compositions containing them, and process for producing them.
JPS5673047A (en) Decaprenylamine derivative
EP0323604A3 (en) A venous extensibility improving and cardiac hypertrophy suppressant agent containing a dihydropyridine compound
DK158513C (da) N-(substitueret phenyl)-n'-pyridinylurinstoffer, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse