PH23506A - 1-aralkyl-substituted-1,2,4,-triazole-5-thiols as dopamine- -hydroxylase inhibitors - Google Patents

1-aralkyl-substituted-1,2,4,-triazole-5-thiols as dopamine- -hydroxylase inhibitors

Info

Publication number
PH23506A
PH23506A PH35265A PH35265A PH23506A PH 23506 A PH23506 A PH 23506A PH 35265 A PH35265 A PH 35265A PH 35265 A PH35265 A PH 35265A PH 23506 A PH23506 A PH 23506A
Authority
PH
Philippines
Prior art keywords
thiols
dopamine
triazole
aralkyl
substituted
Prior art date
Application number
PH35265A
Other languages
English (en)
Inventor
Joseph Alan Finkelstein
Lawrence Ivan Kruse
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of PH23506A publication Critical patent/PH23506A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PH35265A 1986-05-23 1987-05-15 1-aralkyl-substituted-1,2,4,-triazole-5-thiols as dopamine- -hydroxylase inhibitors PH23506A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86643786A 1986-05-23 1986-05-23

Publications (1)

Publication Number Publication Date
PH23506A true PH23506A (en) 1989-08-16

Family

ID=25347617

Family Applications (1)

Application Number Title Priority Date Filing Date
PH35265A PH23506A (en) 1986-05-23 1987-05-15 1-aralkyl-substituted-1,2,4,-triazole-5-thiols as dopamine- -hydroxylase inhibitors

Country Status (15)

Country Link
EP (1) EP0246888A3 (fi)
JP (1) JPS62283967A (fi)
KR (1) KR870011109A (fi)
CN (1) CN87103808A (fi)
AU (1) AU7334487A (fi)
DK (1) DK251087A (fi)
FI (1) FI872249A (fi)
HU (1) HU201530B (fi)
IL (1) IL82542A0 (fi)
NO (1) NO872094L (fi)
NZ (1) NZ220347A (fi)
PH (1) PH23506A (fi)
PT (1) PT84904B (fi)
ZA (1) ZA873653B (fi)
ZW (1) ZW9087A1 (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628059A (en) * 1985-10-31 1986-12-09 Smithklein Beckman Corporation Dopamine-β-hydroxylase inhibitors
DE4230466A1 (de) * 1992-09-11 1994-03-17 Basf Ag Verfahren zur katalytischen Herstellung von Kondensationsprodukten des Formaldehyds
CA2829790C (en) 2010-03-30 2018-06-05 Verseon Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
PT2968297T (pt) 2013-03-15 2019-01-10 Verseon Corp Compostos aromáticos multissubstituídos como inibidores da serina protease
KR20150130405A (ko) 2013-03-15 2015-11-23 베르선 코포레이션 트롬빈의 억제제로서의 할로게노피라졸
WO2016044662A1 (en) 2014-09-17 2016-03-24 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
ES2931460T3 (es) 2015-02-27 2022-12-29 Verseon Int Corporation Compuestos de pirazol sustituido como inhibidores de serina proteasa

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5634673A (en) * 1979-08-31 1981-04-06 Nippon Nohyaku Co Ltd 1,2,4-triazoles and agricultural and horticultural fungicide containing the same
JPS59164783A (ja) * 1983-03-11 1984-09-17 Nippon Soda Co Ltd トリアゾ−ルジスルフイド誘導体及びその製造方法
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
US4628059A (en) * 1985-10-31 1986-12-09 Smithklein Beckman Corporation Dopamine-β-hydroxylase inhibitors

Also Published As

Publication number Publication date
HU201530B (en) 1990-11-28
HUT47920A (en) 1989-04-28
NO872094L (no) 1987-11-24
DK251087A (da) 1987-11-24
PT84904A (en) 1987-06-01
JPS62283967A (ja) 1987-12-09
NZ220347A (en) 1990-05-28
AU7334487A (en) 1987-11-26
ZW9087A1 (en) 1987-09-02
EP0246888A2 (en) 1987-11-25
DK251087D0 (da) 1987-05-18
ZA873653B (en) 1988-08-31
FI872249A0 (fi) 1987-05-21
IL82542A0 (en) 1987-11-30
PT84904B (en) 1989-07-17
NO872094D0 (no) 1987-05-19
EP0246888A3 (en) 1988-09-28
KR870011109A (ko) 1987-12-21
FI872249A (fi) 1987-11-24
CN87103808A (zh) 1987-12-09

Similar Documents

Publication Publication Date Title
GB2192184B (en) Alpha-aryl-alpha-phenylethyl-1h-1,2,4-triazole-1-propanenitriles
ZA879308B (en) 5-benzoxazinyl-and 6-benzothiazinyl-2,3,4,5 tetrahydropyridazin-3-ones
PT86453A (en) 6-benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyrudazin-3-ones
PH25045A (en) 1,2,3,6-tetrahydro-5-nitro-pyrimidine derivatives
ZA8784B (en) 1,6-anhydro-beta-hexopyranose derivatives
PH23506A (en) 1-aralkyl-substituted-1,2,4,-triazole-5-thiols as dopamine- -hydroxylase inhibitors
ZA874093B (en) Certain 2-phenylacetyl-1,3,5-cyclohexanetriones
ZA87428B (en) Novel 2,4-diamino-6-haloalkylpyrimidines
CS932686A1 (en) Zpusob pripravy 2,6 diaminomesitylen 4 sulfonove kyseliny
CS650086A1 (en) Zpusob pripravy 2,6 dichlordifenylaminu
CS393386A1 (en) Sposob pripravy 2,2 dibenztiazolyldisulfidu
GB8725002D0 (en) 2,5-disubstituted-7,7,8,8-tetracyanoquinodimethanes
ZW387A1 (en) 1,6-dicarba-polypeptide compounds
IE860036L (en) DOPAMINE - ß - HYDROXYLASE INHIBITORS.
IE862861L (en) Substituted 1,1,2-triphenylbut-1-enes
IE860757L (en) Substituted 1,8-naphthyridinones
IL100160A0 (en) Substituted 1,2,3-thiadiazole-4-thiolates
GB8602038D0 (en) 3-dimethylamino-7-methyl-1,2,4-benzotriazine-1-oxide
CS748286A1 (en) Zpusob vyroby 3,5 dinitrobenzoove kyseliny
GB8602037D0 (en) 3-dimethylamino-7-methyl-1,2,4-benzotriazine-1-oxide
GB8602036D0 (en) 3-dimethylamino-7-methyl-1,2,4-benzotriazine-1-oxide
CS632986A1 (en) 2,6 dichloranilid kyseliny benzoove
CS649986A1 (en) Zpusob pripravy 2,6 dochlordifenylaminu
CS97186A1 (en) Zpusob cisteni 2,6 dichlordifenylaminu
IE861046L (en) 2,5-diaryltetrahydrofurans