PH12021550452A1 - Methods of treating mycobacterial infections using tetracycline compounds - Google Patents
Methods of treating mycobacterial infections using tetracycline compoundsInfo
- Publication number
- PH12021550452A1 PH12021550452A1 PH12021550452A PH12021550452A PH12021550452A1 PH 12021550452 A1 PH12021550452 A1 PH 12021550452A1 PH 12021550452 A PH12021550452 A PH 12021550452A PH 12021550452 A PH12021550452 A PH 12021550452A PH 12021550452 A1 PH12021550452 A1 PH 12021550452A1
- Authority
- PH
- Philippines
- Prior art keywords
- methods
- mycobacterial infections
- tetracycline compounds
- treating mycobacterial
- treating
- Prior art date
Links
- 208000027531 mycobacterial infectious disease Diseases 0.000 title abstract 3
- -1 tetracycline compounds Chemical class 0.000 title abstract 3
- 206010062207 Mycobacterial infection Diseases 0.000 title abstract 2
- 239000004098 Tetracycline Substances 0.000 title abstract 2
- 229960002180 tetracycline Drugs 0.000 title abstract 2
- 229930101283 tetracycline Natural products 0.000 title abstract 2
- 235000019364 tetracycline Nutrition 0.000 title abstract 2
- JEECQCWWSTZDCK-IQZGDKDPSA-N omadacycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=C(CNCC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O JEECQCWWSTZDCK-IQZGDKDPSA-N 0.000 abstract 1
- 229950004150 omadacycline Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726738P | 2018-09-04 | 2018-09-04 | |
| US201862731410P | 2018-09-14 | 2018-09-14 | |
| US201862746039P | 2018-10-16 | 2018-10-16 | |
| US201862760131P | 2018-11-13 | 2018-11-13 | |
| PCT/US2019/049368 WO2020051151A1 (en) | 2018-09-04 | 2019-09-03 | Methods of treating mycobacterial infections using tetracycline compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12021550452A1 true PH12021550452A1 (en) | 2021-12-06 |
Family
ID=69722600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12021550452A PH12021550452A1 (en) | 2018-09-04 | 2021-03-03 | Methods of treating mycobacterial infections using tetracycline compounds |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12161655B2 (https=) |
| EP (1) | EP3846805A4 (https=) |
| JP (2) | JP7466544B2 (https=) |
| KR (2) | KR20260036400A (https=) |
| CN (1) | CN113164456A (https=) |
| AU (2) | AU2019335203B2 (https=) |
| BR (1) | BR112021004057A2 (https=) |
| CA (1) | CA3111447A1 (https=) |
| MA (1) | MA53564A (https=) |
| MX (2) | MX2021002503A (https=) |
| PH (1) | PH12021550452A1 (https=) |
| SG (1) | SG11202102149SA (https=) |
| WO (1) | WO2020051151A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7840880B2 (ja) * | 2020-06-11 | 2026-04-06 | パラテック ファーマシューティカルズ，インコーポレイテッド | オマダサイクリンの結晶形態、その合成方法及びその使用方法 |
| TW202237116A (zh) * | 2020-12-02 | 2022-10-01 | 日商塩野義製藥股份有限公司 | 以組合細胞色素bc1抑制劑與克拉黴素或阿奇黴素為特徵之用於治療分枝桿菌感染之藥物 |
| JP2024511419A (ja) * | 2021-03-24 | 2024-03-13 | インスメッド インコーポレイテッド | 非結核性抗酸菌肺疾患を治療するための併用療法 |
| WO2025221846A1 (en) * | 2024-04-18 | 2025-10-23 | St. Jude Children's Research Hospital, Inc. | Compositions and methods for treating non-tuberculosis mycobacteria infections |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA009175B1 (ru) | 2000-07-07 | 2007-12-28 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| US20060194773A1 (en) | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| EP2311451A1 (en) | 2002-03-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
| PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| TWI680117B (zh) | 2008-05-19 | 2019-12-21 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| KR101732084B1 (ko) | 2011-07-26 | 2017-05-02 | 케이비피 바이오사이언시즈 씨오., 엘티디. | 9-아미노메틸 치환된 테트라사이클린 화합물 |
| JP2015527403A (ja) | 2012-09-11 | 2015-09-17 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｈｉｖプロテアーゼ阻害剤 |
| CA3018872A1 (en) * | 2016-03-24 | 2017-09-28 | Paratek Pharmaceuticals, Inc. | Methods of treating a bacterial infection in a subject at risk of developing c. difficile infection |
| JP2019514952A (ja) * | 2016-05-02 | 2019-06-06 | パラテック ファーマシューティカルズ，インコーポレイテッド | ９−アミノメチルミノサイクリン化合物及び尿路感染症（ｕｔｉ）の処置におけるその使用方法 |
| TW202206081A (zh) * | 2016-08-03 | 2022-02-16 | 美商派瑞泰Ｓｐｖ２有限公司 | ９—胺甲基米諾四環素化合物及其用途 |
| GB201615693D0 (en) * | 2016-09-15 | 2016-11-02 | Combinatorx Infection Ltd | Combinations |
-
2019
- 2019-09-03 EP EP19858573.9A patent/EP3846805A4/en active Pending
- 2019-09-03 US US17/273,034 patent/US12161655B2/en active Active
- 2019-09-03 AU AU2019335203A patent/AU2019335203B2/en active Active
- 2019-09-03 BR BR112021004057-9A patent/BR112021004057A2/pt unknown
- 2019-09-03 MA MA053564A patent/MA53564A/fr unknown
- 2019-09-03 KR KR1020267005925A patent/KR20260036400A/ko active Pending
- 2019-09-03 CN CN201980072989.8A patent/CN113164456A/zh active Pending
- 2019-09-03 CA CA3111447A patent/CA3111447A1/en active Pending
- 2019-09-03 KR KR1020217009806A patent/KR102933150B1/ko active Active
- 2019-09-03 SG SG11202102149SA patent/SG11202102149SA/en unknown
- 2019-09-03 WO PCT/US2019/049368 patent/WO2020051151A1/en not_active Ceased
- 2019-09-03 MX MX2021002503A patent/MX2021002503A/es unknown
- 2019-09-03 JP JP2021536672A patent/JP7466544B2/ja active Active
-
2021
- 2021-03-02 MX MX2024008671A patent/MX2024008671A/es unknown
- 2021-03-03 PH PH12021550452A patent/PH12021550452A1/en unknown
-
2024
- 2024-04-02 JP JP2024059527A patent/JP2024084794A/ja active Pending
- 2024-10-30 US US18/932,596 patent/US20250332178A1/en active Pending
-
2025
- 2025-09-18 AU AU2025234215A patent/AU2025234215A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021536504A (ja) | 2021-12-27 |
| US20210346408A1 (en) | 2021-11-11 |
| EP3846805A1 (en) | 2021-07-14 |
| CN113164456A (zh) | 2021-07-23 |
| US20250332178A1 (en) | 2025-10-30 |
| US12161655B2 (en) | 2024-12-10 |
| MX2021002503A (es) | 2021-06-15 |
| AU2025234215A1 (en) | 2025-10-16 |
| KR20260036400A (ko) | 2026-03-16 |
| AU2019335203B2 (en) | 2025-06-19 |
| KR102933150B1 (ko) | 2026-03-03 |
| BR112021004057A2 (pt) | 2021-05-25 |
| EP3846805A4 (en) | 2022-08-24 |
| MA53564A (fr) | 2021-07-14 |
| WO2020051151A1 (en) | 2020-03-12 |
| SG11202102149SA (en) | 2021-04-29 |
| MX2024008671A (es) | 2024-07-23 |
| JP2024084794A (ja) | 2024-06-25 |
| CA3111447A1 (en) | 2020-03-12 |
| KR20210090160A (ko) | 2021-07-19 |
| AU2019335203A1 (en) | 2021-05-06 |
| JP7466544B2 (ja) | 2024-04-12 |
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